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Author Topic: Another drug bites the dust  (Read 3100 times)

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Offline worriedsilly

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  • Posts: 12
Another drug bites the dust
« on: September 26, 2012, 10:22:39 AM »
I keep reading about new hepc drugs failing. Is there still hope for new drugs with less side effects being availabe in the next year or two? I'm getting close to needing treatment and these failures are starting to freak me out.

Vertex ends work on one hepatitis C drug, continues another

Offline cookie610

  • Member
  • Posts: 8
Re: Another drug bites the dust
« Reply #1 on: September 28, 2012, 03:46:58 PM »
I thought these new classes were going to bring a bright new day to hep treatment. seems like they are all failing. this can't be good.

Offline Tim Horn

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  • Posts: 51
Re: Another drug bites the dust
« Reply #2 on: October 12, 2012, 01:23:35 PM »
One very important thing to remember is that the hepatitis C drug pipeline is very full with experimental agents and, just as has been the case with other infectious diseases (e.g., HIV), there will always be drugs that don't pan out because of limited effectiveness and safety concerns.

But yes, it does appear as if some of nucleoside/nucleotide polymerase inhibitors have been plagued by safety concerns. Fortunately, though, one of the agents that many are excited about -- Gilead's sofosbuvin (GS-7977) -- showed tremendous potential (with minimal side effects) in early studies and is now in the final stretch of studies needed for approval.

Also keep in mind, there are several other classes of drugs in Phase II and Phase III studies, including at least five NS5a inhibitors, ten protease inhibitors and seven non-nucleoside polymerase inhibitors.

There's a lot of potential in the hep C pipeline!

Tim Horn

Offline worriedsilly

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  • Posts: 12
Re: Another drug bites the dust
« Reply #3 on: October 12, 2012, 02:00:34 PM »
Thanks Tim.

I'll keep holding out hope something new will be available in time.


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