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Author Topic: HARVONI COMPLETION  (Read 14832 times)

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Offline jacattack

  • Newbie
  • Posts: 2
HARVONI COMPLETION
« on: March 11, 2015, 03:04:50 pm »
Hello all,
                New to this site and wanted to share my information with all of those taking the Harvoni medication. Just completed a 16 week treatment. It was going to be a 24 week protocol- but my nys obamacare health insurer decide to pull the plug on my last two bottles -due to that fact my fibrosis score dropped nearly by half after 3 months on the drug. I contracted the disease 35 years ago while on a student exchange in Mexico from shaving with a used razor blade. I am treatment- experienced, having done a 48 week protocol of interferon /ribrovirin in 2003. I cleared the virus with that treatment for nearly 9 months, only to have it come back on me 3 months post-treatment. Hopefully that does not happen again. I would have preferred to take the Harvoni for the full 24 weeks , like my doctor wanted , but the insurance exchanges are penny-wise and dollar foolish with their policy regarding this medication and treatment.If anyone has completed the 12 week regimen of Harvoni and is treatment experienced I would be interested in how things have worked out for you. Thanks, Jack
« Last Edit: March 11, 2015, 03:06:50 pm by jacattack »
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Offline BubbaT

  • Member
  • Posts: 267
Re: HARVONI COMPLETION
« Reply #1 on: March 11, 2015, 03:34:44 pm »
Congrats jack,

Sorry to hear about the stop on week 16, do you have any recourse with gilead for the remainder 8 weeks rx?
Logged
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline charly8

  • Member
  • Posts: 113
Re: HARVONI COMPLETION
« Reply #2 on: March 12, 2015, 02:03:41 pm »
Quote from: jacattack on March 11, 2015, 03:04:50 pm
Hello all,
                New to this site and wanted to share my information with all of those taking the Harvoni medication. Just completed a 16 week treatment. It was going to be a 24 week protocol- but my nys obamacare health insurer decide to pull the plug on my last two bottles -due to that fact my fibrosis score dropped nearly by half after 3 months on the drug. I contracted the disease 35 years ago while on a student exchange in Mexico from shaving with a used razor blade. I am treatment- experienced, having done a 48 week protocol of interferon /ribrovirin in 2003. I cleared the virus with that treatment for nearly 9 months, only to have it come back on me 3 months post-treatment. Hopefully that does not happen again. I would have preferred to take the Harvoni for the full 24 weeks , like my doctor wanted , but the insurance exchanges are penny-wise and dollar foolish with their policy regarding this medication and treatment.If anyone has completed the 12 week regimen of Harvoni and is treatment experienced I would be interested in how things have worked out for you. Thanks, Jack

How was your fibrosis measured?  By fibroscan, fibrosure, or biopsy?
Logged
1a, VL  1.05 Mil, ALT 47
Fibrosure F3 December 2014
Fibroscan F0-F1 March 2015
1995 INT & RYB -non-responder
2007 PEGIN & RYB 72 weeks tx - partial responder relapsed
1/23/15 Started Harvoni 12 weeks, EOT 4/17
2 week blood work -  <15 Und. (ALT 25)
4 week blood work - <15 Und. (ALT 29)
2/20/15 added RYB (4 weeks into 12 of tx)
8 week blood work - <15 Und. (ALT 23)
(EOT) 12 week blood work - <15 Und.
4wk POST tx VL - Und. (ALT16, AST 17)

Offline kate0b1

  • Member
  • Posts: 293
Re: HARVONI COMPLETION
« Reply #3 on: March 13, 2015, 06:12:48 am »
@jack, i just finished 12 weeks yesterday. i am relapsed from triple therapy. i was supposed to get labs today but asked if i could wait until 4weeks and then my 12 weeks in june. My doc is pretty flexible so he was ok with it, i was UND at 4 weeks on tx. now just the waiting for april  ;)

kate
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Offline Sam1224

  • Member
  • Posts: 62
Re: HARVONI COMPLETION
« Reply #4 on: March 14, 2015, 10:20:06 am »
I was prescribed a 12 week Rx of Harvoni. Dr. requested additional 12 weeks at my request and it was approved.
I had been insured through my Wife's insurance until she lost her job. I decided to go with COBRA for a period of time. The expense of COBRA became too hard to manage. I contacted Support path and told them I was going to have to drop the COBRA due to expense. Gilead said they would cover the full cost of my remaining 12 weeks. They implied they would have covered it also if insurance wouldn't. It is very much in Gilead's best interest for successful outcomes on their medications. I would absolutely contact them TODAY.

gen 1
cirrhosis F4 fibrosure
tx naïve
<15 VL @ 4wks
ALT/AST normal @ 4 weeks

 
« Last Edit: March 15, 2015, 09:08:48 am by Sam1224 »
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Offline BubbaT

  • Member
  • Posts: 267
Re: HARVONI COMPLETION
« Reply #5 on: March 19, 2015, 08:37:20 pm »
Hi Sam, what was your reason for requesting the additional 12 weeks being previously non treated?

Are you still on treatment now?

Are you und?

Thanks,   I'm on week 3 with a similar condition as you.  Going 12 weeks...

Logged
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline Karen1124

  • Member
  • Posts: 76
Re: HARVONI COMPLETION
« Reply #6 on: April 09, 2015, 01:14:40 pm »
Hi everyone,
EOT April 1st blood work on the 2 nd  <15 detected! went back today to repeat blood work! Life is good! Karen
Logged
Geno 1a
VL 2 million
DX May 1 2014
Bio June 5 2014
moderate fibrosis
Start Harvoni 2/5/2015
EOT 4/1/2015
 7/22/2014 alt 186 12/30  64  3/5/15  39
7/22/14  ast 114    12/30.  41  3/5/15  27
Don't know how I got hep C in my 20s I did snort coke a few times.
3/5/15 undetected
4/2/15 less than 15 VL ferrin levels normal
4/9/15 undetected!!
6/24/15 relapse VL 424,000
7/26/16 Started treatment today Harvoni and Ribavirin 24 weeks

Offline jacattack

  • Newbie
  • Posts: 2
Re: HARVONI COMPLETION
« Reply #7 on: June 01, 2015, 09:44:27 pm »
Completed a 4 month harvoni treatment on 2/19. Undetectable at 4 weeks EOT. PCR is now detected but <15 @ 13 weeks EOT. Has anybody experienced this with their EOT bloodwork at 12 weeks or beyond?. My nyc gastro says they are seeing this in thier patients after Harvoni and it usually resolves back to undectable as it was for me at 4weeks EOT.. dr says Repeat quanitative pcr test again 1-2 months from now
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Offline Mugwump

  • Member
  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
Re: HARVONI COMPLETION
« Reply #8 on: June 03, 2015, 03:23:49 am »
Quote from: jacattack on June 01, 2015, 09:44:27 pm
Completed a 4 month harvoni treatment on 2/19. Undetectable at 4 weeks EOT. PCR is now detected but <15 @ 13 weeks EOT. Has anybody experienced this with their EOT bloodwork at 12 weeks or beyond?. My nyc gastro says they are seeing this in thier patients after Harvoni and it usually resolves back to undectable as it was for me at 4weeks EOT.. dr says Repeat quanitative pcr test again 1-2 months from now

There is speculation going on about this situation in the medical community to say the least! Some are beginning to suspect that having HCV antibodies can play a role in whether or not you relapse. So there must be some level of immunity afforded by having them.

I look at it this way, I can't pull my liver out and assay it for virus so I have to trust that if there are any infected cells happening post treatment that my immune system will completely remove any virons they spill into the blood stream them before they can cycle back and infect other liver cells. Harvoni tx for most who have cirrhosis will reduce inflammation in the liver and thus promote better immune cell production, so even if Harvoni does not completely block the ability of the virus to replicate perhaps like with interferon/rib it greatly depends upon how well our immune system deals with any virus that manages to evade the drug and re-infect liver cell.

Here is hoping your next test is UND
All the best from a Canuck
Eric
Logged
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline atomic dog

  • Member
  • Posts: 160
Re: HARVONI COMPLETION
« Reply #9 on: June 19, 2015, 01:00:37 am »
Quote from: jacattack on June 01, 2015, 09:44:27 pm
Completed a 4 month harvoni treatment on 2/19. Undetectable at 4 weeks EOT. PCR is now detected but <15 @ 13 weeks EOT. Has anybody experienced this with their EOT bloodwork at 12 weeks or beyond?. My nyc gastro says they are seeing this in thier patients after Harvoni and it usually resolves back to undectable as it was for me at 4weeks EOT.. dr says Repeat quanitative pcr test again 1-2 months from now

There is some discussion that the<15 detected is the test picking up dead virus cells, a false positive. If you were reinfected it seems you'd have much higher numbers since viral load increases exponentially.
Logged
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline dragonslayer

  • Member
  • Posts: 873
Re: HARVONI COMPLETION
« Reply #10 on: June 19, 2015, 12:29:31 pm »
I agree, Atomic. Let's not forget that the Gilead standard for success in the trials was a viral load of < 25 achieved at 12 wks post treatment.. No mention was made of detected or not detected; just a viral load < their test's LLOQ.
Logged
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Karen1124

  • Member
  • Posts: 76
Re: HARVONI COMPLETION
« Reply #11 on: July 02, 2015, 07:56:10 pm »
Hey all,
Had my 12 week post treatment boodwork on June 24th! Bad news for me VL 424,000! It's back! Life is good!! Karen
Logged
Geno 1a
VL 2 million
DX May 1 2014
Bio June 5 2014
moderate fibrosis
Start Harvoni 2/5/2015
EOT 4/1/2015
 7/22/2014 alt 186 12/30  64  3/5/15  39
7/22/14  ast 114    12/30.  41  3/5/15  27
Don't know how I got hep C in my 20s I did snort coke a few times.
3/5/15 undetected
4/2/15 less than 15 VL ferrin levels normal
4/9/15 undetected!!
6/24/15 relapse VL 424,000
7/26/16 Started treatment today Harvoni and Ribavirin 24 weeks

Offline Karen1124

  • Member
  • Posts: 76
Re: HARVONI COMPLETION
« Reply #12 on: July 03, 2015, 08:13:55 am »
Hey all,
Had my 12 week post treatment boodwork on June 24th! Bad news for me VL 424,000! It's back! Life is good!! Karen
Logged
Geno 1a
VL 2 million
DX May 1 2014
Bio June 5 2014
moderate fibrosis
Start Harvoni 2/5/2015
EOT 4/1/2015
 7/22/2014 alt 186 12/30  64  3/5/15  39
7/22/14  ast 114    12/30.  41  3/5/15  27
Don't know how I got hep C in my 20s I did snort coke a few times.
3/5/15 undetected
4/2/15 less than 15 VL ferrin levels normal
4/9/15 undetected!!
6/24/15 relapse VL 424,000
7/26/16 Started treatment today Harvoni and Ribavirin 24 weeks
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