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Author Topic: VIRAL LOAD QUESTION  (Read 7722 times)

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Offline Lee

  • Member
  • Posts: 31
VIRAL LOAD QUESTION
« on: May 19, 2015, 10:05:47 pm »
Hey guys,

I took a viral load test two days short of four weeks and the result was:

"<20 too low to quantify".

So that means the virus is still in there?  I see a lot of you had a result of <15 Undetected.  Why is 15 undetected but 20 is too low to quantify?

I am just wondering what this all means - does anyone know? 

OK, 20 more of those little ______'s to go!! Since I started with 6.6 million, I have to be happy with 20, but I sure wish I had gotten "undetected". Wouldn't it be awful to be this close and not be able to knock it out all the way?!

Appreciate your thoughts on this.

Lee
Female
Infected mid-1970's
Diagnosed 2013
Viral load prior to treatment: 6.6 million
Genotype: 1a
Started Harvoni: 4/20/15
Four week viral load: <20 too low to quantify
Eight week viral load: undetected

Offline Sweetie1

  • Member
  • Posts: 28
Re: VIRAL LOAD QUESTION
« Reply #1 on: May 19, 2015, 10:09:16 pm »
Hi,

   Don't worry mine was < 15 at 8 weeks but at 12 it was negative.

Karen

Offline Lee

  • Member
  • Posts: 31
Re: VIRAL LOAD QUESTION
« Reply #2 on: May 19, 2015, 10:18:12 pm »
Yeah!  Thank you!!
Female
Infected mid-1970's
Diagnosed 2013
Viral load prior to treatment: 6.6 million
Genotype: 1a
Started Harvoni: 4/20/15
Four week viral load: <20 too low to quantify
Eight week viral load: undetected

Offline sabre

  • Member
  • Posts: 77
Re: VIRAL LOAD QUESTION
« Reply #3 on: May 20, 2015, 02:03:42 pm »
Some people are still detected at EOT that go on to SVR12.

My doc doesn't even want to do labs until EOT.

Good luck! You'll be fine.
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: VIRAL LOAD QUESTION
« Reply #4 on: May 23, 2015, 04:05:17 am »
Even not detected does not mean no virus it just means the quantity of virus is below the ability of the test to detect.

Lower limit of quantification (LLOQ) is defined as “the lowest amount of an analyte in a sample that can be quantitatively determined with suitable precision and accuracy” according to FDA1.

I was not detected last year at week 4 and EOT 12 with Sovaldi and Olysio but when tested 12 weeks after treatment was completed I had relapsed back to pre treatment level of 2.4 million viral load

So even though I was not detected I was not virus free.

The only test that matters is 12 weeks post treatment although 4 weeks post treatment still not detected is a very good indication of likely SVR.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Sweetie1

  • Member
  • Posts: 28
Re: VIRAL LOAD QUESTION
« Reply #5 on: May 23, 2015, 09:07:12 am »
I took Harvoni for 12 weeks, negative at end of treatment. Just had 3 month labs after tx.- Virus undetected! So glad! Karen

 


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