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Author Topic: interactions with Harvoni  (Read 10866 times)

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Offline Hippo

  • Newbie
  • Posts: 1
interactions with Harvoni
« on: August 22, 2015, 12:26:34 pm »
How does beer interact with the success of harvoni.  Facts please not opinions.  Thank you.

Offline Mike

  • Member
  • Posts: 999
Re: interactions with Harvoni
« Reply #1 on: August 22, 2015, 03:39:00 pm »
Hi Hippo,
Since Harvoni is such a new drug, there is no definitive research either way. Because of this, and, to error on the side of caution, I would recommend abstaining from alcohol during treatment.

I would talk to your doctor about this.

Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline hepboy1

  • Member
  • Posts: 21
Re: interactions with Harvoni
« Reply #2 on: October 07, 2015, 07:45:48 pm »
has anyone taken milk thistle on harvoni?  sorry cant figure out how to make own post  yet

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: interactions with Harvoni
« Reply #3 on: October 08, 2015, 07:53:32 pm »
hepboy1

http://www.webmd.com/drugs/2/drug-167109/harvoni-oral/details/list-interaction-details/dmid-2412/dmtitle-strong-or-moderate-cyp3a4-inhibitors-simeprevir/intrtype-drug

Harvoni
Interactions
Simeprevir/Strong or Moderate CYP3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:

Amprenavir, aprepitant, atazanavir, boceprevir, cimetidine, ciprofloxacin, clarithromycin, cobicistat, conivaptan, crizotinib, cyclosporine, darunavir, diltiazem, dronedarone, erythromycin, fosamprenavir, fluconazole, imatinib, indinavir, itraconazole, ketoconazole, lopinavir, mibefradil, milk thistle, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, tipranavir, troleandomycin, verapamil, or voriconazole may speed up how quickly your liver processes simeprevir.
What might happen:

The amount of simeprevir in your blood may increase and cause more side effects than expected.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline dragonslayer

  • Member
  • Posts: 873
Re: interactions with Harvoni
« Reply #4 on: October 09, 2015, 09:14:57 am »
Lynn, I believe that site is referring primarily to Olysio interactions, not specifically Harvoni.  It's misleading because it lists both, but if you check other interaction sites re Harvoni and Milk Thistle, I dont believe youll find a connection.
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Scoutdoy

  • Member
  • Posts: 452
Re: interactions with Harvoni
« Reply #5 on: October 09, 2015, 10:46:16 am »
Hippo,
     This is not factual but take it for what it's worth. Giliad did not have any data on alcohol and Harvoni. As far as I know, there is no direct evidence one way or the other with it interfering with the way Harvoni works to clear the virus. Here is what my doc told me about taking different things while on Harvoni. He said No, it doesn't interfere with the Harvoni directly but when one is trying to rid the body of a virus or disease it is best to have all organs functioning at the highest level they can to rid the virus. The liver being one of the most important organs while doing this. Alcohol makes the liver not function at its highest capability while ridding itself of the alcohol consumed. Whether it's 2 hrs for one drink or a whole day for a 12 pack.


Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: interactions with Harvoni
« Reply #6 on: October 09, 2015, 11:29:57 pm »
oops Dragon you are correct. I googled Harvoni interactions guess it pays to read the whole article thanks!

Still though I would think we would want to err on the side of caution while treating and just don't take anything we don't have to and never without our doctors agreement.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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