Hepatitis Forums
Hepatitis C Main Forums => Hepatitis C Research News & Studies => Topic started by: KimInTheForest on September 30, 2018, 01:30:06 pm
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Very interesting article (2 years old) on possible neurological basis for brain fog and cognitive decline/depression in chronic Hep C. From the abstract:
"An association between hepatitis C virus infection and neuropsychiatric symptoms has been proposed for some years. A variety of studies have been undertaken to assess the nature and severity of these symptoms, which range from fatigue and depression to defects in attention and verbal reasoning. There is evidence of mild neurocognitive impairment in some patients with HCV infection, which is not fully attributable to liver dysfunction or psychosocial factors. Further evidence of a biological cerebral effect has arisen from studies using magnetic resonance spectroscopy; metabolic abnormalities correlate with cognitive dysfunction and resemble the patterns of neuroinflammation that have been described in HIV infection. Recent research has suggested that, in common with HIV infection, HCV may cross the blood brain barrier leading to neuroinflammation. Brain microvascular endothelial cells, astrocytes and microglia may be minor replication sites for HCV."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272938/
Even though this article is 2 years old, it was news to me and explains quite a few problems that are discussed by members here.
kim
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Wow interesting info thanks for sharing