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Advanced Liver Disease Main Forums => Advanced Liver Disease => Topic started by: Hep Editors on October 01, 2018, 10:34:54 am

Title: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: Hep Editors on October 01, 2018, 10:34:54 am
The use of proton pump inhibitor (PPI) medications such as Prilosec (omeprazole) and Nexium (esomeprazole) is associated with an increased risk of hepatocellular carcinoma (HCC, the most common form of liver cancer). In a recent large study this increased risk was dose dependent, meaning that longer use of PPIs was tied to a higher risk of liver cancer.

Publishing their findings in Alimentary Pharmacology & Therapeutics, researchers conducted a nested case-control study in which they analyzed data drawn from the Taiwan National Health Insurance Research Database about people without viral hepatitis in the Southeast Asian nation between 2000 and 2013.

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https://www.hepmag.com/article/proton-pump-inhibitors-may-raise-liver-cancer-risk
Title: Re: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: KimInTheForest on October 01, 2018, 11:32:13 am
Wow! A lot of people are on those very common drugs.

kim
Title: Re: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: Lynn K on October 01, 2018, 09:33:40 pm
Unfortunately GERD and acid reflux can cause inflammation and bleeding in the esophagus. Even esophageal cancer can happen, but it's rare.

So kind of a rock and hard place situation for those with cirrhosis and GERD.
Title: Re: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: KimInTheForest on October 01, 2018, 10:44:37 pm
Quote from: Lynn K on October 01, 2018, 09:33:40 pm
Unfortunately GERD and acid reflux can cause inflammation and bleeding in the esophagus. Even esophageal cancer can happen, but it's rare.

So kind of a rock and hard place situation for those with cirrhosis and GERD.

Are there no good options for treating GERD besides PPIs? I think PPIs also contribute to osteoporosis. Should be some better option for people with GERD.
Title: Re: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: Lynn K on October 01, 2018, 11:03:18 pm
Seems to depend partly on the cause. For example being overweight can contribute. In my case I have a hiatal hernia which if worse could be surgically repaired but mine isn’t that bad just chronic heartburn.

The Mayo Clinic suggests OTC meds like Mylanta and Tums or H2 blockers but PPI’s can help repair esophageal erosions the others can’t. There are also suggestions like raising the bed and avoiding spicy foods. As a last resort surgery.

https://www.mayoclinic.org/diseases-conditions/gerd/diagnosis-treatment/drc-20361959
Title: Re: Proton Pump Inhibitors May Raise Liver Cancer Risk
Post by: KimInTheForest on October 01, 2018, 11:12:32 pm
Ah yes - I recall the raised bed thing. I had some severe but short-lived acid reflux or heartburn (not sure if they are the same) when on Harvoni in 2015. Actually thought I might be having a heart attack when it first struck because I had never experienced this before, and it was quite brutal! But I discovered raising head of bed did help. Also not going to bed or lying down shortly after eating.