Hepatitis Forums
Advanced Liver Disease Main Forums => Advanced Liver Disease => Topic started by: Hep Editors on April 02, 2019, 10:26:52 am
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A combination of two immune checkpoint inhibitors, Imfinzi (durvalumab) and tremelimumab, appeared to slow progression of advanced liver and biliary tract cancer in a small study, researchers reported at the 2019 Gastrointestinal Cancers Symposium this month in San Francisco. However—as seen in other studies of immunotherapy for these cancers—the overall response rates are low.
Over years or decades, chronic hepatitis B or C, heavy alcohol use, fatty liver disease and other causes of liver injury can lead to the development of hepatocellular carcinoma (HCC), the most common type of primary liver cancer. HCC is often detected late and is hard to treat. Liver cancer does not respond well to traditional chemotherapy. Targeted therapy—including the standard first-line therapy, Nexavar (sorafenib)—and immunotherapy show some promise, but a majority of patients do not respond and mortality remains high. Biliary tract cancer, involving the gallbladder or bile ducts, is even more difficult to treat.
For more...
https://www.hepmag.com/article/checkpoint-combination-may-slow-liver-biliary-tract-cancer