Hepatitis Forums
Fatty Liver Disease Main Forums => Nonalcoholic Steatohepatitis (NASH) => Topic started by: Hep Editors on March 04, 2020, 10:36:01 am
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An experimental drug that blocks glucose absorption lowered liver enzyme levels, reduced liver fat and led to modest weight loss in people with non-alcoholic steatohepatitis (NASH) in a mid-stage study, according to a presentation at The Liver Meeting, the annual meeting of the American Association for the Study of Liver Diseases, this month in Boston.
Non-alcoholic fatty liver disease (NAFLD) and NASH, its more severe form, are responsible for a growing proportion of advanced liver disease. Accumulation of fat in the liver triggers inflammation, which over time can lead to fibrosis (buildup of scar tissue), cirrhosis, liver cancer and the need for a liver transplant. Fatty liver disease is increasingly recognized as a manifestation of metabolic syndrome, a cluster of conditions that include abdominal obesity, elevated blood glucose and abnormal blood fat levels.
There are currently no effective medical therapies for NASH, and management relies on lifestyle changes such as weight loss. Over the past few years, several NAFLD/NASH therapies that appeared promising based on biomarkers in early studies ended up not improving clinical outcomes in larger trials.
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https://www.hepmag.com/article/licogliflozin-lowers-liver-enzymes-people-fatty-liver-disease