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Advanced Liver Disease Main Forums => Advanced Liver Disease => Topic started by: Hep Editors on June 12, 2020, 06:17:13 pm
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In a pair of new studies, scientists have identified a pair of key proteins that appear to be instrumental in the development of type 2 diabetes; one of them also plays a role in regulating fibrosis (scarring) of the liver. These discoveries in mice may eventually lead investigators to identify treatments that could reverse diabetes and fibrosis in humans.
In one study, published in Nature, scientists conducted their experiments based on the knowledge that fasting causes two proteins, called TET2 and NHF4a, to increase in the liver, which in turn raises the level of blood glucose. In the case of type 2 diabetes, these proteins fail to dissipate after someone eats again as they do in the absence of the disease, thus keeping blood glucose levels abnormally high.
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https://www.hepmag.com/article/researchers-possible-ways-reverse-type-2-diabetes-liver-fibrosis