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Welcome to the Hep Forums, a round-the-clock discussion area for people who have Fatty Liver Disease, Hepatitis B, C or a co-infection, their friends and family and others with questions about hepatitis and liver health. Check in frequently to read what others have to say, post your comments, and hopefully learn more about how you can reach your own health goals.

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Recent Posts

Pages: 1 2 [3] 4 5 ... 10
21
On Hepatitis C Treatment / Re: Third time is the charm? Starting 12 weeks of Vosevi
« Last post by opaleye on December 30, 2023, 03:58:22 pm »
Thanks again for your encouragement! I have to admit I feel a bit like the last kid to be picked for the team, but I'm sure there are others out there who are still waiting for that final SVR.

A month before starting Vosevi my viral load was 1,824,750 with liver enzymes (all high) at ALP = 141, AST = 91, ALT = 75. I was tested for CMP last week and saw encouraging all normal ALP = 108, AST = 26, ALT = 19. Woo hoo!

What's weird (to me) is that this time around my hepatologist doesn't want to check the viral load again until EOT. Huh? I couldn't imagine going through a 12 week treatment without some sort of feedback so I asked my primary care physician to run CBC and CMP after month 1 and month 2.

Thanks for your question about viral loads with the other treatments. That nudged me to organize my lab results and record HVC-specific tests. Here are the stats. Hoping this is helpful to others.

Harvoni (8 weeks treatment)

2014/11/4 -- 2,812,380 -- Before Harvoni
2015/04/2 -- <15 detected -- Harvoni 1 mo
2015/04/30 -- <15 detected -- Harvoni 2 mo EOT
2015/08/13 -- 670,790 -- Post-Harvoni 7.5 weeks (This is when I balled my eyes out)

Mavyret (16 weeks treatment but ended early)

2018/02/22 -- 2,450,000 -- Before Mavyret
2018/11/18 -- Not detected -- Mavyret 1 mo
2019/01/07 -- 90 -- Mavyret EOT 11.5 weeks (stopped due detectable VL and symptomatic bradycardia)
2019/05/15 -- 1,320,000 -- Post-Mavyret 4 mo

I appreciate you sharing the victories along your journey. Kudos to your perseverance in slaying this Dragon!

Happy New Year :)

Annie
22
On Hepatitis C Treatment / Re: Third time is the charm? Starting 12 weeks of Vosevi
« Last post by jberlin on December 28, 2023, 01:57:33 pm »
You got this... Your Hep C history is a novel certainly, and not a short story.

What was your starting Hep C viral load and when will you have your 1st (post treatment start) quantitative Hep C test? Hoping it quickly goes to undetectable. Did your viral load quickly disappear with the other treatments? I remember crying my eyes out when I got news 6 weeks into my 2nd treatment that I was undetectable, as that never happened on the first treatment. (They considered stopping treatment as viral load reduced so slowly - but back then I had less than a 50% chance anyway.)

2024 - Your year of 3 strikes and the Hep C goes down swinging after two foul balls!

Most importantly - stay positive and the time will fly by. Thanks for keeping us informed and helping others with their own dragon fights!

Happy New Year!
jack
23
On Hepatitis C Treatment / Re: Third time is the charm? Starting 12 weeks of Vosevi
« Last post by opaleye on December 27, 2023, 11:06:34 pm »
Hello Jack,

Thanks so much for jumping on this train with me! I really appreciate your kind words and encouragement :)

Week 2 was completed this evening. Woo hoo! Being the nerd I am, I created a spreadsheet that automatically calculates how many days left. Only 70 days to go!

I have had some side effects, most notable headaches and tinnitus, but the headaches are tolerable or manageable with NAIDS and triptans (which have been prescribed for migraines).

The spreadsheet also calculates how much water I'm drinking. Getting to a gallon a day has been a challenge but that is my goal. Most days I add Liquid IV for electrolytes to one of my 20 oz servings (the size of my water bottle). With Harvoni I drank the recommended amount of water but that got my electrolytes out of balance. I'm careful though to take any magnesium opposite the Vosevi dose. Fours hours should be sufficient but I pad that a bit.

I'm doing everything I can for success this time. The only supplements I'm taking are B-2, lysine, and probiotics. I found a resource for Vosevi drug interactions that is much more comprehensive than what the company provides. (https://www.medbroadcast.com/drug/getdrug/vosevi)

Another source mentioned that there could be interactions between Vosevi and ubrogepant (Ubrelvy), which I use on occasion. I spoke to the pharmacist providing the Vosevi and they said that the interaction was just "possible" and that if anything it would make the ubrogepant more active but not alter the effectiveness of Vosevi. I also mentioned another CGRP medication I take, Vyepti (eptinezumab-jjmr), which is an infusion every three months. The pharmacist could not find any contraindications with that medication.

I'm sharing that research in case other migraine sufferers might be reading this :)

There also has been some "intestinal disturbance" and insomnia. Right now I am on vacation so I'm able to sleep in if need be but I'm back to work on Jan. 3; fortunately though working from home. I applied for intermittent Family Medical Leave in case a reduced schedule is needed. I have read that the last few weeks can get rough.

Any other t's to cross or I'd to dot?

Thanks again for your support, and Happy New Year!

annie
24
On Hepatitis C Treatment / Re: Third time is the charm? Starting 12 weeks of Vosevi
« Last post by jberlin on December 22, 2023, 09:27:39 am »
Thanks so much for posting your struggles here, it will help so many others over time. Hep C treatments have gotten so much more effective over 30 years (20% to 90+%), shorter and easier (a year of shots, weight and hair loss - to 12 weeks of pills) - but, as your case points out, not 100% effective.

But what else your story points out is bravery and determinedness - which is as important as the drugs! Also, the need for community during this process. We are here for you, as this forum was here for me so long ago when I relapsed from my first 48 week treatment.

Please update us often along these weeks of your current journey, and certainly after you get your 90 day post treatment viral count of undetectable and you know the dragon is slayed. Third time will be the charm I am sure!

This "Jack" repeats for all relapsers "Go back and do it again!"

Happy New Year!

jack
25
On Hepatitis C Treatment / Third time is the charm? Starting 12 weeks of Vosevi
« Last post by opaleye on December 14, 2023, 07:55:17 pm »
Hello All,

It's been quite a while since I've posted here. LynnK might remember me  :)  So good to see this forum is still up and running. Thank you moderators and members for traveling this journey with us all together.

I failed Havoni and then Mavyret. After five years of recovering from those disappointments, and being primary caregiver to my husband during surgeries due to his diabetes (resulting in a BKA last year), I finally have mustered the strength to, as Steely Dan would say, "go back, Jack, do it again."

Took my first Vosevi tablet a few hours ago. I can't believe how emotional I am. I keep reading the stories on this forum and other forums of Post-Vosevi SVR.... and I feel Hope again.

Time to Slay the Dragon once and for all!
26
Resmetirom Improves NASH and Liver Fibrosis in Phase III Trial

Resmetirom, a leading contender in the race to become the first approved treatment for non-alcoholic steatohepatitis (NASH), reduced liver fat accumulation and improved inflammation and liver fibrosis in a Phase III clinical trial, according to results presented at the EASL Congress in Vienna.

Read more...
https://www.hepmag.com/article/resmetirom-improves-nash-liver-fibrosis-phase-iii-trial
27
While cardiovascular disease (CVD) is a leading cause of morbidity and mortality for people with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), liver fat itself may not raise the risk for heart disease after accounting for other risk factors, according to study findings published in the journal Hepatology.

“Taking this report alone, it suggests that there is no increased risk of CVD in persons with NAFLD above that conferred by other metabolic comorbidities,” Ian Rowe, PhD, of the University of Leeds, and Alina Allen, MD, of the Mayo Clinic, wrote in an accompanying editorial.

Non-alcoholic fatty liver disease and its more severe form, NASH, are responsible for a growing proportion of advanced liver disease worldwide. Often associated with obesity and diabetes, fatty liver disease is increasingly recognized as a component of metabolic syndrome, a cluster of risk factors associated with CVD. Over time, NAFLD can lead to liver fibrosis, cirrhosis and even liver cancer. With no approved medical therapies, disease management is dependent on lifestyle changes such as weight loss and exercise.

Read more...
https://www.hepmag.com/article/fatty-liver-disease-risk-factor-cardiovascular-disease
28
Advanced Liver Disease / Re: Liver Pain after eating
« Last post by Docroccin on August 22, 2023, 04:45:24 pm »
Hey Pete.  Thanks for sharing your story. Helpful info for me.
29
Am I Infected? / Re: Hep c/b exposure?
« Last post by Lynn K on June 10, 2023, 04:52:39 pm »
I’m pretty sure you already know the answer to your question. As you said yourself this is really far fetched and your OCD is likely talking.

My suggestion is to speak with your counselor and get treatment for your OCD.

Likely using cocaine only increases your existing anxieties.

Best of luck to you   
30
Am I Infected? / Hep c/b exposure?
« Last post by Jaydog on June 08, 2023, 01:14:12 pm »
Hi guys,

I appreciate this may sound somewhat farfetched but i recently bought a bag of cocaine for my birthday. I took 2 bumps and used my own key to snort it both times. I gave the bag back to my friend afterwards as i realised this party life is no longer for me.

Im concerned that maybe there was blood inside the bag of cocaine and that maybe i am at risk for a hep c/b infection?. What worries me more is that 3 days later my 1 year old daughter snatched this key from my hand and cut her hand in the process. I am even more concerned now as im worried that any potential leftover blood on the key could have gotten into my daughter's hand when she cut herself.

Now I have no reason to believe there was blood in the cocaine/key, i think its just my ocd playing with me and im very protective over my daughter and i worry about where the cocaine may have come from. For arguments sake, if there was blood in the cocaine which was transferred to my key what are my daughter's risks of contracting the hepatitis virus 3 days after its contact with the cocaine?. I did not notice any visible blood on the key, just a bit of rust from the wear and tear and obviously there was no cocaine left on the key either.

My main worry is for my daughter and i keep reading that trace amounts of blood/virus can transmit this virus

What is mine and my daughter's risk on this?

Thank you in advance

Jay
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