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Author Topic: Just started Harvoni...what time of day is best to take it?  (Read 17501 times)

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Offline Perca05

  • Member
  • Posts: 12
Just started Harvoni...what time of day is best to take it?
« on: March 06, 2015, 01:21:42 pm »
Hi all...I just started my Harvoni, 2 days ago.  I just popped it as soon as it came in the mail, but am wondering if taking it at night is better than during the day.  I do get a little groggy, and but am worried if I take it at night, it will disturb my sleep.  Anyone have trouble taking it at night?

Sure hope it clears me...I did try interferon and ribavirin, with boseprevir in a trial a few years back, but had to stop because of the side effects.   So far with Harvoni, no headache or other sides.  Yay!

Thank you
-------
Last VL count: 4.5 million
AST/ALT 60 / 65
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Offline chino1969

  • Member
  • Posts: 117
Re: Just started Harvoni...what time of day is best to take it?
« Reply #1 on: March 06, 2015, 03:58:14 pm »
I take mine in the morning right before breakfast.  Some days I have mild, but tolerable, headaches.  Other days, the side effects are minimal.  I drink plenty of water and this seems to help; about a gallon a day.
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Offline Lukey

  • Member
  • Posts: 319
  • Let Thy Food Be Thy Medicine
Re: Just started Harvoni...what time of day is best to take it?
« Reply #2 on: March 06, 2015, 05:38:45 pm »
Just take it at the same time of day each day.
I took mine from noon to 1 PM for 8 weeks.

I just finished 8 weeks Tuesday.
Logged
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"
4 weeks post : "<15 not detected"

Offline koifish54

  • Member
  • Posts: 56
Re: Just started Harvoni...what time of day is best to take it?
« Reply #3 on: March 06, 2015, 08:45:43 pm »
I take mine 9am because when first started taking it I wanted to be awake for sx and I was afraid of having insomnia first two weeks I was allittle hyper about 4 hours after taking pill
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Offline Bituman

  • Member
  • Posts: 157
Re: Just started Harvoni...what time of day is best to take it?
« Reply #4 on: March 06, 2015, 08:54:45 pm »
I take mine at 9PM just before bed.  To date no side effects.  My sleep pattern remains unchanged.  No headaches or fatigue.  Been on Harvoni 30 days.

After reading a lot of these threads, there doesn't seem to be any correlation between pill taken time and side effects.  The only caution seems to be to offset pill at least 4 hours from antacids. 

Congrats on getting started!

Bob
Logged
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline Tpropane

  • Member
  • Posts: 65
  • Heal the past by living in the present.
Re: Just started Harvoni...what time of day is best to take it?
« Reply #5 on: March 07, 2015, 02:47:26 am »
I take mine at 8am. I figure I'd rather be through the worst of it and be able to sleep. I take it with a probiotic drink. Iphone alarm. Sometimes I go back to sleep. I can sleep 8-9 hours a night.
Logged
Hep C 1A / TT diagnosed 2009
Non Responder Boceprevir/riba/peg 2011
F-4 Cirrhosis
TX Harvoni 24 weeks started 1/20/15
2 week labs VL 174!
4 week labs UNDETECTED !
8 week labs UNDETECTED !

Offline coloradogirl

  • Member
  • Posts: 70
Re: Just started Harvoni...what time of day is best to take it?
« Reply #6 on: March 07, 2015, 07:14:08 am »
I started treatment 6 days ago, and I wish I could switch to taking the pill in the PM, because I feel fatigued and jittery in the morning after taking it, but feel energized in the afternoon and evening. I battle with insomnia anyway, so I don't know if there would be any difference there.   I certainly would like to use that PM energy in the morning instead. Since I know how important it is, I slam down a lot of water all the live long day.
Logged
HCV 1a diag 2002
1st tx 2004 null responder
2nd tx 2010 clinical trial relapsed
Last biopsy 2010 F2-F3
Fibrosure inconclusive some parameters out of range
Abdominal Ultrasound 7/2015 - No sign of Cirrhosis
Pretreatment  vl 580,000
Started Harvoni 3/2/2015 EOT: 5/24/2015
4th week 3/27/2015 vl < 5.3 Undetected
8th week 4/23/2015 vl <5.3 Undetected
12 week EOT  5/28/2015 vl <5.3 Undetected
4wk after tx 6/26/2015 vl <5.3 Undetected
12wk after tx 8/19/2015 vl<15 Undetected!!!
I'm Cured! Yes!

Offline kate0b1

  • Member
  • Posts: 293
Re: Just started Harvoni...what time of day is best to take it?
« Reply #7 on: March 07, 2015, 07:52:30 am »
I take mine right before i walk out the door for work, mostly though so i don't forget to take it. i am not on any other meds so i am not used to taking anything (i mostly forget my vitamin) then i turn the bottle upside down so i remember that i took it  (mostly that is for the w/e).

kate
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Offline MEG

  • Member
  • Posts: 304
Re: Just started Harvoni...what time of day is best to take it?
« Reply #8 on: March 07, 2015, 04:14:50 pm »
I used to take mine in the evening but I've been experiencing the feeling better/more energetic in the late afternoons and having trouble quieting my mind to sleep(which is generally not an issue).....Requiring hydroxyzine(antihistamine/antianxiety agent) to help me fall asleep.  I'm in my 6th week.

 I've been gradually moving the time I take it earlier and earlier in the day, and today I took it midmorning with breakfast.

It's now early afternoon and still not feeling the energy buzz...so there you have it. H has a mind of its own...LOL...
« Last Edit: March 07, 2015, 04:47:16 pm by MEG »
Logged
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline Perca05

  • Member
  • Posts: 12
Re: Just started Harvoni...what time of day is best to take it?
« Reply #9 on: March 09, 2015, 06:54:52 pm »
Haha...yeah, I am starting to move it to mornings so I don't forget it as well.  I have been having a hard time getting to, and staying asleep though.  Hope that goes away.

Thanks all for your feedback.  :)
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Offline SIXFOOTFOUR

  • Member
  • Posts: 89
Re: Just started Harvoni...what time of day is best to take it?
« Reply #10 on: March 11, 2015, 02:58:18 pm »
Im only on day six of Harvoni but decided to take it in the PM prior to sleep. I hoped that this way if there were any bad side effects Id sleep through them or worst case not have to deal with them during my work day.

So far no problems sleeping and I wake feeling fine no "fog" etc. I do have periods during the day of headaches and light nausea and as others on the forum have suggested drinking as much water as possible and for me a Ibuprofen will take care of the headache if it is persistent
Logged
Sixfootfour
* Contracted Hep C 1971 post transfusion (non A - non
   B Hep dx in 1971)
* Dx as Hep C early 2000
* Geno 1b
* Stage 3-4 Fibrosis by Biopsy and FibroScan
* VL at start of TX > 6 mil
* ALT/AST High normal range at start of Tx 
* Started Harvoni 12 week course 3/6/15 -
   completion 5/29/15
* Undetected at 6 weeks on Tx
* ALT/AST Mid normal range at 6 week blood test
* Completed 12 weeks (84 pills) 6/28/15
* Undetected at 11 weeks & 6 months EOT
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