Could the HCV Drug Sofosbuvir Be Cardiotoxic?

[charly8]

Could somebody comment on this?  There is a lot of medical mumbo jumbo.

http://www.medscape.com/viewarticle/842315

"he ISMP also noted that sofosbuvir was approved under breakthrough rules and "was one of the first noncancer drugs approved without a controlled efficacy trial for its largest patient population.""

"We know a third of the population in the RE-LY trial[4] harbored a single nucleotide polymorphism (rs2244613) that affects CES-1. These patients had lower dabigatran trough concentrations and lower rates of bleeding. Polymorphisms have also been recognized for the P-GP system.

Genetics, therefore, plays a role in how sofosbuvir is metabolized, absorbed, and cleared. You can imagine a subset of patients who are taking a P-GP–inhibiting drug—such as amiodarone—who could also have genetically altered sofosbuvir handling. These patients might be exposed to very high levels of either the prodrug or its active metabolite."