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Author Topic: Immune system  (Read 12722 times)

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Offline beflat10r

  • Member
  • Posts: 21
Immune system
« on: May 01, 2015, 11:59:13 am »
I'm on day 64 of Harvoni. So far still no discernible side effects and the virus is still "undetected" as of my 6 week blood labs and liver doc visit. Amazing!!
My question is does anyone know if one's immune system is compromised in any way from the Harvoni? It must be some kind of STRONG drug if it's knocking out a previously seemingly difficult virus to eradicate.
Im wondering because I RARELY get sick. No colds. No flu ( no flu shots ) and I'm youthful middle age too so it's not a new thing for me to not be sick. About 4 weeks ago i got a cold. It seemed like it was going away with my coughing subsiding but returned a few days later and way worse so much so that I actually went to the doc and I had bacterial pneumonia. After 2 different doses of antibiotics- and I've taken them maybe 2xs in my life, it all is subsiding. I called the Harvoni pharmacy in Maine- they send me the Harvoni- and immediately they claimed the immune system is not compromised in any way. ... so....
any thoughts or experience would be appreciated.
Thanks,
Bb Bob
Logged
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline sabre

  • Member
  • Posts: 77
Re: Immune system
« Reply #1 on: May 02, 2015, 12:08:33 am »
I had a similar experience as you just before I started taking Harvoni. Head/chest cold blossomed into full blown Pneumonia. It actually delayed my start date by a week as my doctor said to wait until the Pneumonia had subsided before beginning. By the way, I also have kidney disease which predisposes me to Pneumonia.

It is indeed very strong medication, and relatively new, so all of the nuances are probably not fully understood yet. I'm on day 35 and have felt great (knock on wood) throughout treatment. Could just be coincidence...or if you were inactive during your cold and/or from being fatigued from treatment, that could be a factor in acquiring Pneumonia as well.

Good luck on your treatment and beyond.
Logged
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline beflat10r

  • Member
  • Posts: 21
Re: Immune system
« Reply #2 on: May 02, 2015, 01:09:21 am »
Thanks for your reply. Good luck to you and your treatment and beyond also.
Logged
Clean and sober 6/19/89
dx gt 1a 5/2000 bummer!
No treatment
Monitored via ultrasounds and bloodwork and great liver doc for last 15yrs
Totally covered for Harvoni
Started Harvoni 2/27/15
Viral load 1,476,109
Feel like I hit the lottery!

Offline atomic dog

  • Member
  • Posts: 160
Re: Immune system
« Reply #3 on: May 03, 2015, 02:32:50 pm »
There are a handful of folks on this forum who have or have had pneumonia after starting Harvoni, but who knows the relationship there. Our immune systems are compromised already from liver disease. I'll be curious down the road to learn if Harvoni is impacting us--lots of folks talk about the Harvoni cough, for example. I have a week to go. Looking forward to being done.
Logged
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline MEG

  • Member
  • Posts: 304
Re: Immune system
« Reply #4 on: May 03, 2015, 10:50:10 pm »
Indeed...some of us suffered through pneumonia or sinusitis--the latter was mine.

Exactly 2 weeks post finishing Harvoni and I feel better today than I have felt in months...truly. I had to make myself rest this evening after doing "stuff" all day for fear of relapsing myself...

Eventually we'll have answers to all these questions. It's the price we pay for wanting/getting treated so early after approval....don't get me wrong. I'm very grateful. I won't know for another 2 weeks if I'm relapsing or not---but still grateful I've had this opportunity to off this thing!

Good luck all with your treatment.  It really does go by in the blink of an eye.
Meg
Logged
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Immune system
« Reply #5 on: May 03, 2015, 11:04:01 pm »
It has been a tough cold and flu season this year as well so hard to say what is the causal factor
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline MEG

  • Member
  • Posts: 304
Re: Immune system
« Reply #6 on: May 03, 2015, 11:05:49 pm »
You're so right, Lynn. Keep hearing it from people in various parts of the country...

Hey, is tomorrow the day?
Logged
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Immune system
« Reply #7 on: May 03, 2015, 11:25:03 pm »
Yes it's the last dance with Harvoni tomorrow :)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline MEG

  • Member
  • Posts: 304
Re: Immune system
« Reply #8 on: May 03, 2015, 11:27:55 pm »
Oh my God. I thought so!

Woooooooo! Shivers here, Lynn....................

Onward to S. V. R. baby!
Logged
Geno 1a. IL28B+ with TT polymorphism.
Diagnosed 1993.
Liver Biopsy 1993 --inflammation.
Fibroscan 2014---no fibrosis.
ALT range---60s
AST range---80s.
Platelets: 200K range.
Viral load--2 million range.

Began Harvoni on January 23.
Finished 12 week course on April 19.

May 18---4 week EOT labs:
VL: UNDETECTED.
AST: 23
ALT: 22...........These have not been this low throughout treatment and since my 20s.

12 weeks EOT on July 15---Undetected.

Offline BubbaT

  • Member
  • Posts: 267
Re: Immune system
« Reply #9 on: May 04, 2015, 02:25:00 am »
Congrats Lynn!

You did it! You have punched your ticket!

God bless and heal you completely!
Logged
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Immune system
« Reply #10 on: May 04, 2015, 02:57:56 am »
So I guess after tomorrow the 4 week (6/1) and 12 week (7/27) wait begins.

Fingers, toes, eyes, and ears crossed ;)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!
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