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Author Topic: miss dose  (Read 8546 times)

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Offline crackerjohn

  • Member
  • Posts: 5
miss dose
« on: April 08, 2016, 03:32:43 am »
Hello everyone,
I usually take my SOF+DCV every night around 9:00 PM. I have been on schedule for 74 days until last night. I forget to take the combo until this morning at 8:00 AM. Should I take my next dose at 9:00 PM tomorrow night or 8:00 AM tomorrow morning?
Many thanks for advise.
John
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Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: miss dose
« Reply #1 on: April 08, 2016, 08:33:02 am »
Hi John, I found this on a thread here. It may answer your question:

"TaKe HARVONI exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.
 Do not stop taking HARVONI without first talking with your healthcare provider. If you think there is a reason to stop taking HARVONI, talk to your healthcare provider before doing so.
 Take HARVONI 1 time each day.
 Take HARVONI with or without food.
 If you miss a dose of HARVONI, take the missed dose as soon as you remember the same day. Do not take more than 1 tablet of HARVONI in a day. Take your next dose of HARVONI at your regular time the next day."
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Gaj

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  • Posts: 172
  • Optimist
Re: miss dose
« Reply #2 on: April 08, 2016, 08:44:38 am »
Hi crackerjohn,

just saw Philadelphia's response while posting this so if you follow the "only one dose per day" strictly then you should probably change the timing of your doses to 8.00am.

But the usual recommendation I have seen is that if you take your missed dose within 18 hours then you should take the next one at the normal time which for you would be 9.00pm tonight. I would not advise delay to 9.00pm tomorrow which would create two 36 hour gaps in a row.

http://www.catie.ca/en/fact-sheets/hepatitis/harvoni-ledipasvir-sofosbuvir
« Last Edit: April 08, 2016, 08:46:28 am by Gaj »
Logged
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline crackerjohn

  • Member
  • Posts: 5
Re: miss dose
« Reply #3 on: April 08, 2016, 08:56:35 am »
Quote from: Philadelphia on April 08, 2016, 08:33:02 am
Hi John, I found this on a thread here. It may answer your question:

"TaKe HARVONI exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.
 Do not stop taking HARVONI without first talking with your healthcare provider. If you think there is a reason to stop taking HARVONI, talk to your healthcare provider before doing so.
 Take HARVONI 1 time each day.
 Take HARVONI with or without food.
 If you miss a dose of HARVONI, take the missed dose as soon as you remember the same day. Do not take more than 1 tablet of HARVONI in a day. Take your next dose of HARVONI at your regular time the next day."
Thank you, according to this I should take my next dose tomorrow 9:00 PM. Correct?
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Offline crackerjohn

  • Member
  • Posts: 5
Re: miss dose
« Reply #4 on: April 08, 2016, 08:59:13 am »
Quote from: Gaj on April 08, 2016, 08:44:38 am
Hi crackerjohn,

just saw Philadelphia's response while posting this so if you follow the "only one dose per day" strictly then you should probably change the timing of your doses to 8.00am.

But the usual recommendation I have seen is that if you take your missed dose within 18 hours then you should take the next one at the normal time which for you would be 9.00pm tonight. I would not advise delay to 9.00pm tomorrow which would create two 36 hour gaps in a row.

http://www.catie.ca/en/fact-sheets/hepatitis/harvoni-ledipasvir-sofosbuvir
That's what concerns me exactly. Two 36 hour gap in a row.  :(
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Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: miss dose
« Reply #5 on: April 08, 2016, 09:15:24 am »
I'd listen to GAJ, I'm a mathematical bimbo. ;)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline HazelAustralia

  • Member
  • Posts: 178
Re: miss dose
« Reply #6 on: April 08, 2016, 09:51:03 am »
Call Gilead?
Logged
Female age 53
Australia
Contracted in the 1980's
Genotype 1A
VL 314k

Started treatment with Veikira Pak and Ribaviron on Thursday 17th December 2015
NOT DETECTED, End of Treatment, 16th March 2016

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: miss dose
« Reply #7 on: April 08, 2016, 11:27:50 am »
Sorry if I find this a bit funny.  During my 12 weeks of tx, there were about 5 times when I had to count all of the pills in the bottle backwards in time.  This was complicated by the fact that, with all of my travel, I hid emergency doses in my back pack, toiletry bag etc.  I was quite neurotic about it.  From what I had heard a double dose, was borderline overdose for some people and I feared completely skipping a day could give the virus a comeback advantage.  I had to laugh at myself. 

Anyway, the one time I actually figured out I did forget, I did as they say and took the dose right away which was in the early evening (I always took it between 9:30 Am and 12 noon) and then I took the next dose splitting the time difference the following day and worked back to my time scheduled.

Probably not that big of a deal in retrospect. 
Logged
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline crackerjohn

  • Member
  • Posts: 5
Re: miss dose
« Reply #8 on: April 09, 2016, 12:35:17 pm »
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Offline crackerjohn

  • Member
  • Posts: 5
Re: miss dose
« Reply #9 on: April 09, 2016, 12:37:50 pm »
Quote from: beto on April 08, 2016, 11:27:50 am
Sorry if I find this a bit funny.  During my 12 weeks of tx, there were about 5 times when I had to count all of the pills in the bottle backwards in time.  This was complicated by the fact that, with all of my travel, I hid emergency doses in my back pack, toiletry bag etc.  I was quite neurotic about it.  From what I had heard a double dose, was borderline overdose for some people and I feared completely skipping a day could give the virus a comeback advantage.  I had to laugh at myself. 

Anyway, the one time I actually figured out I did forget, I did as they say and took the dose right away which was in the early evening (I always took it between 9:30 Am and 12 noon) and then I took the next dose splitting the time difference the following day and worked back to my time scheduled.

Probably not that big of a deal in retrospect.
I admit I am paranoid on this. I end up doing the same thing like you: I took the next dose splitting the time difference the following day and worked back to my time scheduled.
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