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Author Topic: Hepatitis B re-activated by Harvoni treatment?  (Read 7506 times)

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Offline Cowgirl062

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  • Posts: 3
Hepatitis B re-activated by Harvoni treatment?
« on: November 05, 2016, 03:50:11 pm »
I just read that there are some cases of hepatitis B, been reactivated by harvoni treatment is this true? What should I be watching for? I am six weeks into Harvoni treatment. No hep c virus detected after 4 weeks.  :)
« Last Edit: November 05, 2016, 03:52:25 pm by Cowgirl062 »

Offline Gaj

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  • Posts: 172
  • Optimist
Re: Hepatitis B re-activated by Harvoni treatment?
« Reply #1 on: November 05, 2016, 06:20:41 pm »
Hi Cowgirl, this is only a problem if you have previously had HBV and were unable to clear it and developed 'chronic' HBV. Here is an earlier post I made on this subject.

http://forums.hepmag.com/index.php?topic=4494.msg46077#msg46077
Male - 61 years
Genotype 3a (since 1978?)
Diagnosed 2012
Treated 2013 PEG/Riba/Dac (Relapsed)
F4 - HCC#1 Resected 06/15 - #2 RFAblated 11/15
11/18/15 Commenced Generic Tx - Sof/Dac/Riba (24wks)
Pre Tx = ALT: 270  AST: 209  ALB: 31
05/05/16 = ALT: 34  AST: 32  ALB: 40  VL: Undetected (EOT)
06/16/16 = Relapsed
06/23/16 = ALT: 92  AST: 59  ALB: 40  VL: 290,770
01/12/17 3rd Tx - Zepatier + Sofosbuvir (16wks)
05/03/17 EOT und
06/22/17 SVR7 und
07/27/17 SVR12 UND!
10/26/17 SVR24 UND & Cured!!!

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Hepatitis B re-activated by Harvoni treatment?
« Reply #2 on: November 05, 2016, 08:42:56 pm »
Hi Cowgirl

Were you ever infected with hepatitis B? If not then this is not a concern for you.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Cowgirl062

  • Member
  • Posts: 3
Re: Hepatitis B re-activated by Harvoni treatment?
« Reply #3 on: November 05, 2016, 09:12:42 pm »
Yes, I was infected with hep b but it cleared. I carry the antibodies.

Offline Cowgirl062

  • Member
  • Posts: 3
Re: Hepatitis B re-activated by Harvoni treatment?
« Reply #4 on: November 05, 2016, 09:15:05 pm »
Thanks Gaj I'll check out your previous post!

Offline Lynn K

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  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Hepatitis B re-activated by Harvoni treatment?
« Reply #5 on: November 05, 2016, 09:16:48 pm »
Ok then so from the link Gaj posted

Gaj posted

Not an expert and just repeating what I have been told but apparently there are four tests for HBV.

1) Hep B surface antibodies
2) Hep B core antibodies
3) Hep B Surface Antigen
4) Hep B DNA PCR

The group of people at risk are those who have 2) Hep B core antibodies but do not have 1) Hep B surface antibodies. If you are in that group then you have chronic (dormant/inactive) HBV and are at slight risk of reactivation should you clear HCV. The numbers this has occurred to are very small but sufficient that the FDA have required a warning.

Most adults (~90%) who contract HBV will clear it naturally and become immune. If that happens you will have both 1) and 2) antibodies and are not chronic (dormant/inactive). I assume that most who have chronic HBV would have been informed of that by their doctors but it should be easy to check if you aren't sure. 


But to be totally sure always ask your doctor
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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