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Author Topic: First Post- 4 Week Results  (Read 13641 times)

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Offline KJG

  • Member
  • Posts: 8
First Post- 4 Week Results
« on: May 08, 2015, 10:34:59 am »
Hello,

Hoping for some direction or guidance.  My Dad has stage 4 cirrhosis and is on Harvoni for 12 weeks. We received his four week results yesterday and he went from 6 logs to 2.1 logs.  I was told that they were hoping for undetected after for weeks but are pleased with the significant drop.   Has anyone else had this type of result and are  now undetected?  The significant drop is still a good thing?

Thanks to all.
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Offline SIXFOOTFOUR

  • Member
  • Posts: 89
Re: First Post- 4 Week Results
« Reply #1 on: May 08, 2015, 10:43:35 am »
KJG

This is way to early to worry. If he is showing any improvement its good. Results are slightly different for some. Do a little search and you will see a lot of members are undetected at 4-6 weeks and some are now still showing very low almost undetected VL at EOT but at SVR 12 ( 12 weeks post tx) are undetected.

Overall the success rate seems to be very good. have your dad stick to it , finish the course and he will probably do well.

Best of luck
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Sixfootfour
* Contracted Hep C 1971 post transfusion (non A - non
   B Hep dx in 1971)
* Dx as Hep C early 2000
* Geno 1b
* Stage 3-4 Fibrosis by Biopsy and FibroScan
* VL at start of TX > 6 mil
* ALT/AST High normal range at start of Tx 
* Started Harvoni 12 week course 3/6/15 -
   completion 5/29/15
* Undetected at 6 weeks on Tx
* ALT/AST Mid normal range at 6 week blood test
* Completed 12 weeks (84 pills) 6/28/15
* Undetected at 11 weeks & 6 months EOT

Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #2 on: May 08, 2015, 10:53:08 am »
Thank you very much. I appreciate this. 
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Offline BubbaT

  • Member
  • Posts: 267
Re: First Post- 4 Week Results
« Reply #3 on: May 08, 2015, 11:21:01 am »
Hi klg,

Yes, the main thing is to focus on the end game and do what the dr tells him,
I'm in similar as your dad, I'm at 9 weeks and so far I'm undetected and doing better,
Is your dad still working ? Be encouraged, the meds are working, time will tell...

Stay positive and learn all you can to help your dad.

God bless
Logged
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #4 on: May 08, 2015, 11:53:12 am »
Hello,

He's been in and out of hospital since August of last year. He's had GI bleeds as well as taps on his abdomen.  He's also paraplegic.  They are now giving him strong antibiotics for a urine infection and bone infection from pressure sores.  Two of his main doctors are positive but then we meet residents in hospital who don't know the full picture who don't seem interested in the plan we have for him.  I'm taking the result as a positive Because it's a significant drop, just worry about the meds they're giving him and his other health issues. 

Thank you!
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Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #5 on: May 08, 2015, 12:35:57 pm »
thanks to all for your replies.  Very encouraging.  I'm glad you are doing better :)
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Offline SIXFOOTFOUR

  • Member
  • Posts: 89
Re: First Post- 4 Week Results
« Reply #6 on: May 08, 2015, 01:28:11 pm »
KJG
Stay positive and proactive. If your dad is ill and on other meds be persistant with his care team and be sure they have taken into account he is on Harvoni. Harvoni is a very new drug and not every combination of interaction with other meds has been explored so you really need to have a good GI team that is active in his care to be sure that everything is working towards a positive outcome.

Im on a lot of maintenance meds and wen following up I have not always been able to get absolute answers either from my MD or Gilaid Support because they will say it is not been tested so we have to use some amount of common sense and in my case I minimize any med or d/c it until Im done with the harvoni if I cant get a direct answer that they have researched it with harvoni.

Good luck!
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Sixfootfour
* Contracted Hep C 1971 post transfusion (non A - non
   B Hep dx in 1971)
* Dx as Hep C early 2000
* Geno 1b
* Stage 3-4 Fibrosis by Biopsy and FibroScan
* VL at start of TX > 6 mil
* ALT/AST High normal range at start of Tx 
* Started Harvoni 12 week course 3/6/15 -
   completion 5/29/15
* Undetected at 6 weeks on Tx
* ALT/AST Mid normal range at 6 week blood test
* Completed 12 weeks (84 pills) 6/28/15
* Undetected at 11 weeks & 6 months EOT

Offline Katie

  • Member
  • Posts: 784
Re: First Post- 4 Week Results
« Reply #7 on: May 08, 2015, 01:33:00 pm »
KJG:  I believe I read somewhere that if after 4 weeks you have a 2 log drop, they consider that a strong responder, so your dad is doing very well.  At 4 weeks my test was VL 59.  I am one of those that tested <15 IU/mL but detected at EOT and at 8 weeks post treatment came back Undetected!  So your dad is doing good.

Good luck and let us know how he is doing!

Enjoy the weekend knowing your dad is on the journey with all of us and is doing good!

Katie
Logged
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: First Post- 4 Week Results
« Reply #8 on: May 08, 2015, 08:37:23 pm »
Hi KJG

I desperately wanted to be und at 4 weeks but I wasnt. I dropped from 340,000 to 40 by week 4. I was pretty bummed, but all other markers (ALT, AST, GGT etc) continue to fall so I take comfort in that and in knowing others have been in my shoes.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline DisabledHepcat

  • Member
  • Posts: 44
Re: First Post- 4 Week Results
« Reply #9 on: May 09, 2015, 02:39:45 pm »
Stage four cirrhosis is high for only getting 12 weeks, 24 weeks maybe needed which is recommended for this scenario. The problem is that Harvoni doesn't just go into a working mode because you swallowed a pill. Harvoni works after the liver metabolizes it. If you have cirrhosis and your liver is not working properly it cannot metabolize the Harvoni as good so you need to take it longer.
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Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #10 on: May 09, 2015, 03:07:57 pm »
Thanks to all.
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Offline Bituman

  • Member
  • Posts: 157
Re: First Post- 4 Week Results
« Reply #11 on: May 09, 2015, 05:13:59 pm »
Quote from: KJG on May 08, 2015, 10:34:59 am
We received his four week results yesterday and he went from 6 logs to 2.1 logs.  I was told that they were hoping for undetected after for weeks but are pleased with the significant drop.   Has anyone else had this type of result and are  now undetected?  The significant drop is still a good thing?

Speaking for all the nerds in here, "6 logs" means a viral load of about 1,000,000.  "2.1 logs" means a viral load of about 126.  That's clearly a significant drop in VL and on par with what many of us have seen. Congrats to your father. 

Bob
Logged
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #12 on: May 09, 2015, 08:08:49 pm »
Hi,

Thank you!  I'm still confused about the logs thing lol. It was 6.16 to 2.1. But I'm happy as long as it's a good thing :) 

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Offline Katie

  • Member
  • Posts: 784
Re: First Post- 4 Week Results
« Reply #13 on: May 09, 2015, 09:51:36 pm »
Quote from: KJG on May 09, 2015, 08:08:49 pm
Hi,

Thank you!  I'm still confused about the logs thing lol. It was 6.16 to 2.1. But I'm happy as long as it's a good thing :)

 A logarithim is a short cut for really big numbers.  If the question put to you is "How many numbers do we multiply to get 7.924.270 with a base of 10 (how many 10's)?   You basically count how many 10 places and in the case of millions it is 6, (10 million or more would be 7)  It is the reverse of squaring or cubing....(exponential) a number.

Example How many 2's (base of 2 instead of 10) do we need to get to 8?

2 X 2 X 2 = 8 so the answer is log(2) = 3

Base 10 is usually used in science or medical calculations and it just makes dealing with very large or very small numbers easier to deal with and that is what they deal with when looking at how a person is responding  to treatment.

 So using Log(10)
10 X 10 = 100 (or 10 squared)   Log(10) = 2 
10 X 10 X 10 (or 10 cubed)  Log(10) = 3

Hope that helps KJG.

Katie
Logged
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #14 on: May 10, 2015, 10:57:24 pm »
Thanks Katie!

Today he has encephalopathy. Not a good day. He has decompensated cirrhosis and 30% function left. i hope that Harvoni will work and he can get somewhat better and be less symptomatic but days like today are difficult 

Thanks to everyone who replied.  It's been helpful and comforting.

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Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: First Post- 4 Week Results
« Reply #15 on: May 11, 2015, 08:37:51 am »
or if you want to appear really maths-smart without all the effort of actually BEING maths-smart, you can use this website. You are unlogarithming. I know that's probably not a real word but still.

http://www.rapidtables.com/calc/math/Log_Calculator.htm

From a friend on another board:

"For a log calculation fill in the boxes like this:
log [10]  [number]
Hit calculate

For example, if viral load is 345678 and you want to know the log
Put [10] in the small box and 345678 in the number box, hit calculate and we get log 5.54 (rounded up)

For an anti-log calculation:
Put log number in the small box and hit calculate.

For example, you put 5.54 in the very small box, hit calculate and we get 346737

Slight difference is because we only used two decimal places."

Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline KJG

  • Member
  • Posts: 8
Re: First Post- 4 Week Results
« Reply #16 on: May 11, 2015, 10:50:23 am »
I've been told his prognosis is poor even with Harvoni. Still not given a life expectancy.  I've been told that the pressure ulcers are the problem and wouldn't be considered for a transplant. They are planning on operating on the sores after Harvoni but who knows if he would survive the surgery
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Offline Ahealthyliver

  • Member
  • Posts: 5
Re: First Post- 4 Week Results
« Reply #17 on: May 17, 2015, 09:30:16 am »
Good Morning Genotyoe 3 friends. I have had a great time reading all of your posts!
I am in my 6th week of treatment. At week 4 my viral load has come down from 8 million when I stared treatment to 15 (just 15) at week 4.
I think that is awesome.
I have been treated twice before with
Interferon alone 1 shot a day
Then with the rib and interferon 1 shot a week.
I do have a few issues with the treatment, nothing like with the interferon though.
Dry eyes
Itchy at night, that seems odd to me
I feel very tired, that is getting to be a little worst now. Have you all noticed that?
Also, I am very pale, odd because I am in the sun by my pool everyday for an hour or so, that is all of the sun I can handle since starting the meds.
If anyone has any insight please let me know.
Thanks


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