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Author Topic: Ribavirin Levels  (Read 9276 times)

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Offline drummerman

  • Member
  • Posts: 538
  • For those regarded as warriors....
Ribavirin Levels
« on: August 15, 2015, 04:34:16 pm »
I have noticed a few on here that have had their riba levels tested and were found to have too much in the blood stream.

Has anyone else ever had this test??

thanks,
dm
Logged
Diagnosed07
Interferon/riba 2008 - non-responder
5/16/15 - AST -34
ALT - 35_ HCV RNA - 10,783,000
 7/6/15 - started viekira/riba
8/11/15  Week 5 <15 vl,  AST 18, ALT 18
9/11/15 Week 9  "HCV NOT DETECTED"!
AST 16, ALT 11.  10/16/16 - 2 weeks post EOT = "HCV NOT DETECTED!   AST - 18,  ALT 14
12/29/15 -12 wk EOT-HCV NOT DETECTED! AST 23, ALT 15
3/26/16 - 24 wk post EOT - HCV NOT DETECTED!! AST 19, ALT 21
1 yr eot - AST 20, ALT 17

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Ribavirin Levels
« Reply #1 on: August 15, 2015, 06:32:13 pm »
Me. The test I had was developed at my treating hospital here in Australia.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline drummerman

  • Member
  • Posts: 538
  • For those regarded as warriors....
Re: Ribavirin Levels
« Reply #2 on: August 15, 2015, 07:59:43 pm »
Thanks Phili,

Wonder if they do this test in the U.S.   Anyone?

I hate this one size fits all (or should I say two sizes fits all).  If they could measure the level of riba in your blood stream , then they could tailor your meds to maintain the proper blood levels.   Too much to ask I suppose.

dm
Logged
Diagnosed07
Interferon/riba 2008 - non-responder
5/16/15 - AST -34
ALT - 35_ HCV RNA - 10,783,000
 7/6/15 - started viekira/riba
8/11/15  Week 5 <15 vl,  AST 18, ALT 18
9/11/15 Week 9  "HCV NOT DETECTED"!
AST 16, ALT 11.  10/16/16 - 2 weeks post EOT = "HCV NOT DETECTED!   AST - 18,  ALT 14
12/29/15 -12 wk EOT-HCV NOT DETECTED! AST 23, ALT 15
3/26/16 - 24 wk post EOT - HCV NOT DETECTED!! AST 19, ALT 21
1 yr eot - AST 20, ALT 17

Offline sickpuppy

  • Member
  • Posts: 51
Re: Ribavirin Levels
« Reply #3 on: August 16, 2015, 03:50:24 pm »
There's an article floating around that basically states your Ribavirin dose should be tied to your GFR (rate of toxin clearance by your kidneys as far as I know) and not necessarily to your weight.
Logged
GT1a - TX-naive

Baseline:

16.2 kPa
ALT: 61 iu/L
ALP: 74 iu/L
Albumin: 38g/L
Bilirubin: 27 umol/L
Platelets: 80
VL: 792,000
History of 4 violent varices bleeding episodes and splenomegaly present.

21/07/15 - TX start - Harvoni + Ribavirin 12 weeks.
Week 2 - UND
Week 4 - UND
Week 8 - UND
13/10/15 Week 12 - UND
19/11/15 - SVR4
8/1/16 - SVR12 !!!!!

Offline drummerman

  • Member
  • Posts: 538
  • For those regarded as warriors....
Re: Ribavirin Levels
« Reply #4 on: August 16, 2015, 07:31:50 pm »
That makes total sense sickpuppy,

thats what I suspected.

I have always been super-sensitive to drugs of any kind and t his riba is  hyping me up waaayyy too much.

dm
Logged
Diagnosed07
Interferon/riba 2008 - non-responder
5/16/15 - AST -34
ALT - 35_ HCV RNA - 10,783,000
 7/6/15 - started viekira/riba
8/11/15  Week 5 <15 vl,  AST 18, ALT 18
9/11/15 Week 9  "HCV NOT DETECTED"!
AST 16, ALT 11.  10/16/16 - 2 weeks post EOT = "HCV NOT DETECTED!   AST - 18,  ALT 14
12/29/15 -12 wk EOT-HCV NOT DETECTED! AST 23, ALT 15
3/26/16 - 24 wk post EOT - HCV NOT DETECTED!! AST 19, ALT 21
1 yr eot - AST 20, ALT 17

Offline sickpuppy

  • Member
  • Posts: 51
Re: Ribavirin Levels
« Reply #5 on: August 17, 2015, 04:46:42 am »
Hyping you up...

I mean I don't want to be an ass, but really, if that's the side effect you're complaining about enough to start wanting tests, you've got too much time on your hands.

Just relax, take a breather, go take a day off relax by the pool in the shade, have a smoothie and watch the nice birdies.
Logged
GT1a - TX-naive

Baseline:

16.2 kPa
ALT: 61 iu/L
ALP: 74 iu/L
Albumin: 38g/L
Bilirubin: 27 umol/L
Platelets: 80
VL: 792,000
History of 4 violent varices bleeding episodes and splenomegaly present.

21/07/15 - TX start - Harvoni + Ribavirin 12 weeks.
Week 2 - UND
Week 4 - UND
Week 8 - UND
13/10/15 Week 12 - UND
19/11/15 - SVR4
8/1/16 - SVR12 !!!!!

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Ribavirin Levels
« Reply #6 on: August 17, 2015, 07:59:40 am »
RBV caused all sorts of sx for me, from rampaging bilirubin levels to hb levels where I could hardly walk up a flight of stairs. My renal markers were all over the shop and we had no idea what was going on until among a battery of tests we discovered that I absorbed RBV far too well and had a much higher concentration in my bloodstream than was necessary as a therapeutic level.

They immediately dropped my rbv dosage and it must still be working pretty well because I am still anaemic, in fact more anaemic now than at any other point in my treatment. But I have 3 weeks left and I think I'm just going to tough it out.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline sickpuppy

  • Member
  • Posts: 51
Re: Ribavirin Levels
« Reply #7 on: August 17, 2015, 08:07:38 am »
That's quite a difference from drummerman's "way too hyped". Of course, you needed to check that out.

But even all that can be prevented if you just do a blood test every 2 weeks to keep an eye on the hemoglobin.
Logged
GT1a - TX-naive

Baseline:

16.2 kPa
ALT: 61 iu/L
ALP: 74 iu/L
Albumin: 38g/L
Bilirubin: 27 umol/L
Platelets: 80
VL: 792,000
History of 4 violent varices bleeding episodes and splenomegaly present.

21/07/15 - TX start - Harvoni + Ribavirin 12 weeks.
Week 2 - UND
Week 4 - UND
Week 8 - UND
13/10/15 Week 12 - UND
19/11/15 - SVR4
8/1/16 - SVR12 !!!!!

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Ribavirin Levels
« Reply #8 on: August 17, 2015, 08:17:27 am »
Keeping an eye on my hb with two weekly blood tests might deal with the hb, but my creat., e-GFR, albumin, conjugated and unconjugated bilirubin were all crazy. As well as my HB, most of my red cell indices and one or two other things as well that I cant remember now. Once I dropped the rbv down everything settled down.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell
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