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Author Topic: Treatment for Genotype 2a/2c  (Read 9081 times)

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Offline hepclady

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Treatment for Genotype 2a/2c
« on: February 24, 2016, 08:35:09 am »
Hi,

I just got my Genotype back and I am 2a/2c.  So apparently I am not a candidate for Harvoni.

I would love to hear from anyone else who is Genotype 2 also and if they have done any of the recent treatments and did it work and how did it go?

Thank you very much for any information.

I am still trying to navigate this forum and hope I am posting in the correct place.



Offline Lynn K

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  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment for Genotype 2a/2c
« Reply #1 on: February 24, 2016, 02:08:59 pm »
Here is a link to the AASLD treatment guidelines scroll down for recommendations for GT2 the treatment for all quasi species of gt2 is the same so 2a and 2c have the same treatment

http://www.hcvguidelines.org/full-report/initial-treatment-hcv-infection

Here is an excerpt there is more information on the link


Recommended regimen for treatment-naive patients with HCV genotype 2 infection.
Daily daclatasvir (60 mg*) and sofosbuvir (400 mg) for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection who cannot tolerate RBV.

Rating: Class IIa, Level B

Daily sofosbuvir (400 mg) and weight-based RBV for 12 weeks is recommended for treatment-naive patients with HCV genotype 2 infection.

Rating: Class I, Level A

Extending treatment to 16 weeks is recommended in patients with cirrhosis.

Rating: Class IIb, Level C
 



Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lynn K

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  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment for Genotype 2a/2c
« Reply #2 on: February 24, 2016, 02:15:44 pm »
Here is a link for the prescribing information for Sovaldi (sofosbuvir)
On page 24 it lists clinical trial results for GT 2 which was 95% SVR

There is additional data for gt2 from other trials but your odds are very good

http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Treatment for Genotype 2a/2c
« Reply #3 on: February 26, 2016, 04:20:01 pm »
And sof/dac is a great treatment that is easy to take with minimal side effects for most.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline hepclady

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  • Posts: 7
Re: Treatment for Genotype 2a/2c
« Reply #4 on: February 27, 2016, 03:38:33 pm »
Thanks, sof/dac is the treatment I am hoping for.

Thanks for the information.

Offline Lynn K

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  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Treatment for Genotype 2a/2c
« Reply #5 on: February 27, 2016, 04:14:15 pm »
Unfortunately at this time daclinza (daclatasvir) would be an off label usage. Per the prescribing information sheet is is for genotype 1 and 3 only if course this likely will be revised at some point. But it does make it more difficult getting it approved by your insurance.

http://packageinserts.bms.com/pi/pi_daklinza.pdf

Also Sovaldi/Ribavirin was slightly more effective for GT 2 at 95 vs 92%
 
http://www.ncbi.nlm.nih.gov/m/pubmed/24428467/

It looks like Sovaldi RIBA is preferred over sof/dac except if the patient is Ribavirin intolerant.

Good luck

« Last Edit: February 27, 2016, 04:17:16 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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