I am on vosevi retreatment

[mcmaklin]

Hello 2 days ago I was in the middle of my 2nd retreatment. When should it be zero. I paste my history below, please have a look do we have anyone here who was not UND at week 6? 4 days ago I was <12 but still detected.




1st treatment: Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U start of treatm. After 2 weeks 120U. After a month below possib of detect. After 3 months UND.3EOT UND. 4wEOT RELAPSED,14Dec2016 VL 27000 IU.mL,Feb 2016 VL 24296 IU/mL,  May 2016 VL 106675 IU/mL .L31M in NS5A.Y93H not pres. No NS3 D168/A/F/H/N/Y

2ndTreatment: Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

[Lynn K]

The only test that matters is the 12 week post treatment test result. All on treatment testing is really just to ensure patient compliance as everyone will either test not detected or very nearly so on treatment.

Try not to worry about being weakly detected on treatment. It doesn’t mean anything

[mcmaklin]

When were you undetected while treatment? Just curious?

[Lynn K]

I was undetected on treatment but several people were we even had a couple who were detected 4 weeks after treatment ended most notably dragonslayer. But he went on to achieve SVR at 12 weeks post treatment. He is still hep C free over three years post.

This was Harvoni but the mechanism of action similar.

Even being not detected on treatment does not guarantee success.  I was not detected the entire time I was taking Solvaldi and Olysio but when tested at 12 weeks post treatment I was found to have relapsed to pre-treatment levels.

 That is why I say the only test that matters is the 12 week post test.

[andrew j]

Hi mcmaklin,

I left you a post on that other thread you posted on.

A.