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Author Topic: enlarged spleen  (Read 18064 times)

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Offline trapper

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  • Posts: 56
enlarged spleen
« on: December 27, 2014, 08:55:16 pm »
My c-scan in feburary showed a enlarged spleen along with enlarged liver.  I'm 8 weeks in on s/o treatment.  my ast and alt are now down in normal ranges.  Will my spleen go down in size with my liver or is their something I need to be concerned with.  Has anybody had or have a enlarged spleen with hep c and what did you do. thanks trapper   

Offline Lynn K

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  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: enlarged spleen
« Reply #1 on: December 27, 2014, 10:08:49 pm »
Will your enlarged spleen improve maybe.

I have cirrhosis and portal hypertension that results in having an enlarged spleen and also low platelets because they ar being held in the spleen which is what causes the enlargement. Do you know what your fibrosis score is or your platelet count?

Have you asked your liver doctor what is the cause of your enlarged spleen? That would be the best place to go for answers.

Good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline trapper

  • Member
  • Posts: 56
Re: enlarged spleen
« Reply #2 on: December 28, 2014, 10:36:32 am »
hi lynn.  thanks for your reply.  my liver biopsy results say;  portal inflammation/piecemeal necrosis 3+,  lobular necroinflammatory activity 2+,  fibrosis 3+,  iron stain; 2-3+.     my platelet ct before treatment  147  after 4 weeks of treatment s/o 159.  alt before treatment  121 after 4 weeks treatment 39.  ast before 64 after 20.  trapper

Offline Lynn K

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  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: enlarged spleen
« Reply #3 on: December 28, 2014, 04:03:41 pm »
Ok per your biopsy you were F3 one stage before F4 aka cirrhosis. Your platelets were close to normal before treatment so that's good. My platelets are in the 80 to 90 range.

How old is your biopsy?

But if I were you I would ask my doctor about the cause of the enlarged spleen especially since your platelets look reasonable and you have fibrosis F3 so no cirrhosis at that time.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline trapper

  • Member
  • Posts: 56
Re: enlarged spleen
« Reply #4 on: December 28, 2014, 05:15:18 pm »
Thanks Lynn.   Ct scan in Feb showed Chrossis.  Biopsy in Aug. All in 14'. Should a person get a sonigram done. I'll ask Dr.   Thanks trapper.

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: enlarged spleen
« Reply #5 on: December 28, 2014, 05:52:56 pm »
Dunno about different testing. All I have ever had were biopsies until I was F4 cirrhosis and abdominal ultra sounds. Had a fibroscan this fall to confirm cirrhosis again 7 years later just i case my insurance needed it. Never had a catscan.

If you have cirrhosis that is likely the cause of your enlarged spleen. They do say that once we get rid of hep c our livers may be able to heal and so maybe your spleen will return to normal over time. No one knows for sure.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline HHburme

  • Member
  • Posts: 117
  • Harvoni start 12/13/14 12wks UD/24wk DET
Re: enlarged spleen
« Reply #6 on: December 28, 2014, 06:10:38 pm »
My spleen was removed after rupturing in 1977, received several blood transfusions and that is most likely when i was infected. My platelet count is high, increasing every one of the last 6 years. Maybe because I don't have a spleen, IDK.
infected age 19, blood transfusion 1977, detected 2003  GT 1a, Harvoni relapse 06/15, Clinical Trial Study for SOF/VEL GS-9857 start 02/16. SVR12 Cured 08/16

Offline Rubye

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  • Posts: 130
Re: enlarged spleen
« Reply #7 on: December 28, 2014, 10:46:35 pm »
Hi Trapper,

An enlarged spleen is very common with cirrhosis. Here's a very good article that will explain a lot to you. http://hepatitiscnewdrugs.blogspot.com/2010/11/cirrhosis-what-happens-when-spleen-is.html

I also have cirrhosis and an enlarged spleen with a rather low platelet count - it was 65 before treatment and with my last labs they were up to 85. I say this so I can let you know that I have had no side effects from the low platelets. So far anyway. My doctor told me they don't really worry until they down to around 35.

Best wishes to you for a great new year.

Offline Johnny_Wayne

  • Member
  • Posts: 47
Re: enlarged spleen
« Reply #8 on: January 04, 2015, 10:51:58 pm »
This is good information. I was in a tiff because my platelets are about 86 and I didn't know what to make of the info. Thanks again.
Diagnosed 04/2014
Started Harvoni 10/2014
Undetectable 01/2015
Relapsed 04/2015
F4 Cirrhosis (Compensated - barely)
Child Pugh Score 6-7
MELD Score 10
Started Olysio/Sovaldi/Ribavirin (24 weeks)
EOT Not Detected 11/9/2016
--------------------------------
5-10-2017
Virus undetected SVR 24 Achieved
I AM FINALLY CURED!

Offline trapper

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  • Posts: 56
Re: enlarged spleen
« Reply #9 on: January 10, 2015, 11:25:32 am »
john wayne.  my platelets are about what yours are and I asked my dr about platelets.  He said they are all over the place in regards to the number.  I'v been in normal range and below normal.
I asked about my enlarged spleen and weather it will return to normal size.  He said it probably would not reduce in size because it is caused from portal hyptertension.  depends on how bad you are.  good luck  trapper

 


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