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Author Topic: Side effects of Sovaldi/Olysio  (Read 6085 times)

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Offline katheK

  • Member
  • Posts: 7
Side effects of Sovaldi/Olysio
« on: January 17, 2015, 07:36:55 pm »
Hello!  This is my first time posting in the forum. I have HCV for 25 years, genotype 1a and have been on Sovaldi/Olysio for 6 days now, this is the inteferon/Riba free version, for which I am extremely grateful.  I don't have fibrosis.

I have some side effects including tiredness but then insomnia and brain fog a little dizziness and nausea.  These really took me by surprise because I expect nothing but the sun exposure effects.

My doc RX for the insomnia - it works but I was wondering if it might be better to take it at night? While these aren't horrible (and on the weekend so much more endurable than at work where I have to really focus) but I would rather not have the brain fog.  This AM I noticed that it was not there when I woke up but within an hour of taking meds all of the side effects were back.

I took a nap and miracles - side effects are way less.  So my thinking was, if I took the meds at night might this help with the foggy head, and would it increase the insomnia?  Thanks so much all of you wonderful people.  :)

Contracted: 1989
Treatment naive
GT: 1a
Dx 1999
Baseline prior to tx 1/7/15: 5.5M
F: 0-1
TX: Sovaldi/Olysio 1/12/15
EOT 4/4/15
UD since week 4

Offline Ronaldo

  • Member
  • Posts: 25
Re: Side effects of Sovaldi/Olysio
« Reply #1 on: January 20, 2015, 01:07:51 pm »
  Hi Kathe
 I was treated with the same combo and finished Thanksgiving. I tested N/D so far but I have the post treatment labs at the end of February. I was asked when I ate my largest meal of the day. Mine was supper and was told to take them after eating. I think it was to lessen side effects. I took my meds about 7pm every night and always ate first. I mostly had headaches, fatigue and brain fog. I really didn't have an insomnia problem. Water was key in avoiding my headaches. I am retired so that makes a big difference, I knew work would have been difficult for me.
  I wish you good luck and hope you get the big reward after treatment.

Offline Lynn K

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  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Side effects of Sovaldi/Olysio
« Reply #2 on: January 20, 2015, 01:45:50 pm »
I was on Sov Oly March 14 to Jun 14 did not really notice any sides was cautious about the sun. I believe Olysio is supposed to be taken with food if I remember correctly.

Good luck on treatment
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!


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