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Author Topic: Four Week Results...still detected  (Read 16446 times)

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Offline RiseUp

  • Member
  • Posts: 45
Four Week Results...still detected
« on: January 28, 2015, 06:40:12 pm »
Hi fellow warriors, finally got my 4wk results back:

                     ALT          AST         VL

12/16/14        83            67         4,169,639

01/15/15        22            23              21

Doc is ordering Riba to give Harvoni an extra boost.  Anyone else doing the Harvoni/Riba combo?

started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline dragonslayer

  • Member
  • Posts: 873
Re: Four Week Results...still detected
« Reply #1 on: January 28, 2015, 06:49:19 pm »
Riseup...  to lend some context to your post, please tell us what your treatment history is, your planned treatment duration,  and what condition your liver is in.. Thank you.
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,539
  • Get tested, get treated, get cured, fight Hep c!
Re: Four Week Results...still detected
« Reply #2 on: January 29, 2015, 02:45:12 am »
Hi Riseup

Yes context would be helpful

I am treating with Harvoni for 24 weeks at week 9 we added Ribavirin to treatment so 9 weeks of just Harvoni and 15 weeks of Harvoni with Riba because of my treatment history.

I was UND at week 4 of treatment.

Good luck on treatment
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Hepfreein15

  • Member
  • Posts: 4
Re: Four Week Results...still detected
« Reply #3 on: January 29, 2015, 04:14:57 pm »
I thought HARVONI was sovaldi and ribivarin in one.

Offline Mike

  • Global Moderator
  • Member
  • Posts: 999
Re: Four Week Results...still detected
« Reply #4 on: January 29, 2015, 04:46:19 pm »
Hi Hepfreein15,

Harvoni is Sovaldi (sofosbuvir) combined with Ledipasvir in a single pill.

Sometimes, Ribavirin is taken along with Harvoni to boast the effectiveness  in difficult to treat populations.

Ribavirin is a HCV nucleoside inhibitor; while Ledipasvir is an HCV NS5A protein inhibitor. Although both are HCV inhibitors, they have different mechanisms of action.

Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline Hepfreein15

  • Member
  • Posts: 4
Re: Four Week Results...still detected
« Reply #5 on: January 29, 2015, 07:07:23 pm »
TY for the clarification Mike

Offline Upbeat

  • Newbie
  • Posts: 1
Re: Four Week Results...still detected
« Reply #6 on: January 29, 2015, 07:58:37 pm »
Hi All,

Started Harvoni 12/15/14.  Occasional very mild headaches but work schedule and daily routines are uninterrupted.  Received UND notification from Gastroenterologist after 4th week lab results.

Upbeat
Started Harvoni 12/15/14 (approved 24 wks if needed)
Lab 4 wks Harvoni 01/06/15
Genotype 1a
Starting vl >10.5mil
Stage&Grade: 3-4 (5 biopsies in15 years)
2 University Research Studies - both placebos  :-[
Infected early '70s
Peg-Interferon/Riba 24 months/2003
Detected at 3 months post treatment

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected
« Reply #7 on: January 29, 2015, 08:19:27 pm »
dragonslayer, Lynn K:  Started Harvoni Dec 17 for 12 wks, because still detected after 4 wks (vl 21) doc wants to add Riba which I will begin next week.  8 week blood work will be done on Feb 10.

dx 1997 1a (3,900,000) probably infected early 1970's, treated with Infergen 1997; Interferon and Riba 1999 and 2000, all non-respond.  Liver bio 2/4.

I'm keeping positive and looking forward to next blood work.

Keep the faith everyone.

started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,539
  • Get tested, get treated, get cured, fight Hep c!
Re: Four Week Results...still detected
« Reply #8 on: January 30, 2015, 04:05:12 am »
Hi RiseUp

Does liver bio 2/4 mean inflammation 2 fibrosis 4? Do you have cirrhosis? If you do you need 24 week of Harvoni.

So far I had my 1 week on riba blood test and my hemoglobin is still within normal at 11.9 with minimum normal is 11.1

Good luck hope your next viral load is UND!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected
« Reply #9 on: February 02, 2015, 07:53:29 pm »
Hi Lynn K, No I do not have cirrhosis. Results of my last liver bio (2011): inflammation 1-2/4 and fibrosis 2/4.  Compared to the prior bio (2006): inflammation 2/4 and fibrosis 2/4. Diagnosis: inflammation and fibrosis is slightly decreased.

Waiting for my riba to be delivered tomorrow (Tues). 

Thanks Lynn and continued success with your treatment. 
« Last Edit: February 02, 2015, 11:23:52 pm by RiseUp »
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected (riba to be added)
« Reply #10 on: February 04, 2015, 09:29:55 am »
Just started day 50 today and day 1 of riba.  8 week blood work next Tues 2/10.

Keep the faith fellow warriors.
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline bridget

  • Member
  • Posts: 36
Re: Four Week Results...still detected
« Reply #11 on: February 04, 2015, 08:10:52 pm »
RiseUp,
Did it really take 2 weeks for you to receive your report from your 4 week labs? That's a long time!  I wonder if they did your labs now, if you would be UND?
So, you will be taking Ribavirin for your last 4 weeks of Harvoni treatment, is that correct? 
I'm asking because I'm wondering if I should ask my doctor to add Ribavirin to my last 4 weeks of Harvoni.  My 8 week labs showed <15 (detected)  vs. my 4 week labs showed UND.  My 12 week labs would be at EOT, so too late to do anything at that point.
I'm debating whether or not to ask my dr. about adding Ribavirin.  It would be helpful to refer him to any article that recommends this.
RiseUp, Lynn, have you read anything about the benefit of adding Ribavirin to Harvoni?
Lynn, I'm glad your combo is working :)
Cheers

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,539
  • Get tested, get treated, get cured, fight Hep c!
Re: Four Week Results...still detected
« Reply #12 on: February 05, 2015, 03:17:49 am »
Not sure if there would be any benefit for someone in your situation.

If it was me I would contact my doctor and ask for their recommendations
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline bridget

  • Member
  • Posts: 36
Re: Four Week Results...still detected
« Reply #13 on: February 05, 2015, 08:16:16 am »
Hi Lynn,
Yes, I agree, I am waiting to hear back from the doc.
Have a great day!

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected
« Reply #14 on: February 05, 2015, 07:21:36 pm »
Hi bridget, actually got my results 4 days after blood was drawn, except my viral load which I received within the following week.  I waited to post the results together. I started Riba yesterday (2/4) and will be going to my doc for my 8 week blood work this coming Tuesday (2/11).  I will then be one week on Harvoni and Riba.  Looking forward to being undetected.  Will post my results as soon as I received them.  Today is day 51 Harvoni and day 2 Riba.

Lynn, how are you doing on Riba?

Keep the faith fellow warriors.  8)
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline Tpropane

  • Member
  • Posts: 65
  • Heal the past by living in the present.
Re: Four Week Results...still detected
« Reply #15 on: February 05, 2015, 11:32:26 pm »
Dear Rise up. A 2011 liver biopsy, in my humble opinion, is kind of out of date. A new fibroscan or ultrasound at minimum should be done determine the status of your liver now. At the very least ask your doc what he or she thinks about it.
I went from f1 to cirrhosis in 3 years.So did another poster here. Rapid liver damage after treatment for non responders or non naive patients appears to be more common than I thought. My doctor said it wasn't all that unusual for it to happen so quickly. A bit ironic for HCV to sit around for 35 years and not do much then sort of bloom at this stage of the game. Personally I think the drugs I took in 2011 to fight this insidious disease may have played a key role in how fast my liver took a turn for the worse. A big shock for me to find out that I was cirrhotic to say the least. Better to find out now and get the 24 weeks if necessary. Or be happy if it is still the same! I hope that it is. Only wishing you all the best.
Send love to your liver!
Good luck!
TPropane
Hep C 1A / TT diagnosed 2009
Non Responder Boceprevir/riba/peg 2011
F-4 Cirrhosis
TX Harvoni 24 weeks started 1/20/15
2 week labs VL 174!
4 week labs UNDETECTED !
8 week labs UNDETECTED !

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,539
  • Get tested, get treated, get cured, fight Hep c!
Re: Four Week Results...still detected
« Reply #16 on: February 06, 2015, 12:19:24 am »
Hi Rise UP

So far ok on the riba waiting on the results for my two week CBC drawn on Tuesday.

On Monday I will have completed 12 weeks of treatment so halfway there!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected
« Reply #17 on: February 06, 2015, 10:27:54 pm »
Hi Tpropane, I did have a fibroscan last January.  My kPa Median score was 4,0.  I will be completing my 8th week on Harvoni this Tuesday.  Thanks for your input and wishing you all the best with your treatment.

Keep the faith fellow warriors 8)
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline badbradley

  • Member
  • Posts: 294
Re: Four Week Results...still detected
« Reply #18 on: February 07, 2015, 10:31:45 pm »
Hi All,

Started Harvoni 12/15/14.  Occasional very mild headaches but work schedule and daily routines are uninterrupted.  Received UND notification from Gastroenterologist after 4th week lab results.

Upbeat
Started Harvoni 12/15/14 (approved 24 wks if needed)
Lab 4 wks Harvoni 01/06/15
Genotype 1a
Starting vl >10.5mil
Stage&Grade: 3-4 (5 biopsies in15 years)
2 University Research Studies - both placebos  :-[
Infected early '70s
Peg-Interferon/Riba 24 months/2003
Detected at 3 months post treatment
Hello Upbeat and welcome to the forum! I like your handle. Good to see the undetected at 4 wks.  Hope this is the cure for you! Good luck!     Brad
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline krissy402

  • Newbie
  • Posts: 2
Re: Four Week Results...still detected
« Reply #19 on: February 09, 2015, 08:30:21 pm »
I started Harvoni January 7, 2015...I just started my second bottle, I am on the 8-week treatment. Everyone keeps talking about the 4-week blood work.  My Gastro has told me that I will get tested 8 weeks after I stop. 
Does anyone know what happens if the Hep C is still detected after the treatment on Harvoni?

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,539
  • Get tested, get treated, get cured, fight Hep c!
Re: Four Week Results...still detected
« Reply #20 on: February 09, 2015, 11:13:16 pm »
I guess they would either retreat for longer or try a new med but best to ask your doctor and don't worry about this unless you find yourself there. This medicine has a very high cure rate.
One day at a time ok?
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected (update 8 week results)
« Reply #21 on: February 13, 2015, 06:46:38 pm »
Hi all, just got a call from my doc with my 8 week results:

                                         UNDETECTED!!!

                                        PRAISE THE LORD


Keep the faith fellow warriors :)
« Last Edit: February 13, 2015, 06:56:40 pm by RiseUp »
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline Islandgirl

  • Member
  • Posts: 295
  • Started Harvoni 12/3/14 - EOT 2/25/15
Re: Four Week Results...still detected
« Reply #22 on: February 13, 2015, 07:11:51 pm »
It is indeed a "Praise The Lord" day!  Congrats on your wonderful results, RiseUp! 8) ...Islandgirl
1b, treatment naive, positive for Hep C since 1994; thought to be transmitted via blood transfusions in 1976
Started Harvoni 12/3/14, EOT 2/25/15
12/31/14 labs - Virus Undetected, ALT/18, AST/34
3/25/15 labs - 1 mo post 12 wk Harvoni TX Virus Undetected!!  :) ....Islandgirl

Offline anniemybaby

  • Member
  • Posts: 133
Re: Four Week Results...still detected
« Reply #23 on: February 13, 2015, 08:34:52 pm »
Krissy I'm also just starting my 2nd bottle and am on treatment for 8 wks like you I have the same worry's what if at the end of 8 wks I'm still detected I mentioned that to my Dr she says don't worry about that now n if it does happen there's newer drugs around the corner but harvoni has such a high cure rate my Dr expects me and the rest of her patients to b cured from harvoni think positive
Annie

Offline RiseUp

  • Member
  • Posts: 45
Re: Four Week Results...still detected...8 week update
« Reply #24 on: February 15, 2015, 06:30:56 pm »
Thanks Islandgirl, continued good luck with your treatment.


Keep the faith fellow warriors :D
« Last Edit: February 15, 2015, 06:32:28 pm by RiseUp »
started Harvoni 12/17 (12wks)
dx 1997 1a (3,900,000)
infected early 70's
infergen 1997
interferon & riba 1999 and 2000
liver bio 2/4
started riba feb 4th
undetected vl feb 10th
finished 12wks mar 10
extended to 24 weeks

Offline krissy402

  • Newbie
  • Posts: 2
Re: Four Week Results...still detected
« Reply #25 on: March 02, 2015, 08:27:55 pm »
Congratulations to everyone who is undetected!  I have two pills left now, then I wait for the 12-week post treatment blood test.  I have felt good the whole time on Harvoni and have been able to work.  Thinking positive and taking it one day at a time is really good advice.  Good Luck to all of us! :D

 


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