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Author Topic: 6 days on Harvoni-very bad side effects  (Read 22596 times)

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Offline bud345

  • Member
  • Posts: 7
6 days on Harvoni-very bad side effects
« on: March 11, 2015, 11:37:59 am »
I'm on my sixth day taking Harvoni and things started out ok but as of yesterday my side effects hit me hard. I read all the info before taking Harvoni about the possible side effects and I looked at the % of people having headaches, insomnia etc.  and thought it will be no problem compared to my prior treatment with interferon. Yesterday my fifth day I had flu like symptoms and severe diarrhea that has continued today.
I emailed my Doctor and he says the drug is new and my Specialty Pharmacy tells me the same thing that the side effects are still not completely known.
Has anyone else had the same side effects? or is it just me.

Offline BubbaT

  • Member
  • Posts: 267
Re: 6 days on Harvoni-very bad side effects
« Reply #1 on: March 11, 2015, 01:21:35 pm »
Hey bud, yes, I hit a bad day yesterday, day 7, last nite and felt
Nausea and fever, I was having chills and a little later vomiting, the aches in joint were the worst so far, hardly slept, bad headache was up every hr, drinking water,

Today day 8' took aspirin , I sleep till noon, took the meds and lots of water, I'm starting to feel better. Have not ate anything.
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline dragonslayer

  • Member
  • Posts: 873
Re: 6 days on Harvoni-very bad side effects
« Reply #2 on: March 11, 2015, 02:45:46 pm »
A couple weeks in, I had flu like symptoms... Later on, I had a stomach issue with fever for a day.. I just assumed the flu like symptoms came from a cold, and the stomach thing was  from a bug I caught from somebody and it disappeared as quickly as it began...   Fact is, we really dont know if these symptoms even have anything to do at all with Harvoni.  I dont believe mine did.  I think the so called side effects were a breeze with this med.

Incidentally, I just got over a 5 day cold similar to the one I caught when taking Havoni.. Only now, I havent taken Harvoni for 6 wks... These things happen.. We catch colds; we catch stomach bugs.
« Last Edit: March 11, 2015, 02:47:47 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Lukey

  • Member
  • Posts: 319
  • Let Thy Food Be Thy Medicine
Re: 6 days on Harvoni-very bad side effects
« Reply #3 on: March 11, 2015, 08:07:20 pm »
I felt flu like for about 2 days but that went away almost as fast as it came on.

I'd not worry about it much. It means the meds are probably working.
Try to stay the course, The SFX will most likely go away soon.
At least that's what happened to me and many people here.
 
Drink LOTS of water. It's a must on treatment.
You need at least 2 quarts of water daily.
« Last Edit: March 11, 2015, 08:59:03 pm by Lukey »
Male -  HCV since 1982 - Born 1951 ~ Geno 1a

Did 8 weeks of Harvoni in 2015. Got normal AST & ALT and undetected VL by week 5, then relapsed 4 weeks post.
-----------------------------------------------------------
July 5, 2018 : began 12 weeks of Vosevi with a VL of 540,000 and AST & ALT of 65 and 105.
2 weeks in : AST 19, ALT 20
5 weeks in : AST 18, ALT 12, VL "<15 detected"
10 weeks in : AST 19, ALT 14, VL "<15 not detected"
4 weeks post : "<15 not detected"

Offline atomic dog

  • Member
  • Posts: 160
Re: 6 days on Harvoni-very bad side effects
« Reply #4 on: March 11, 2015, 10:19:42 pm »
I also had diarrhea and cramping for the first two weeks (also headaches, tiredness), but Week 3 was better and Week 4 even better than that. Watch your diet, eat low fat and cut the sugar intake (puts less stress on your liver). One day at a time.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline WV senior

  • Newbie
  • Posts: 1
Re: 6 days on Harvoni-very bad side effects
« Reply #5 on: March 22, 2015, 01:29:47 pm »
Just started the second month of treatment when I became very ill, with cramping and diarrhea. There was some vomiting the first day. It's now the fourth day. Going to the doctor in the morning.

Offline atomic dog

  • Member
  • Posts: 160
Re: 6 days on Harvoni-very bad side effects
« Reply #6 on: March 22, 2015, 09:59:48 pm »
good to check in with the doctor. There's a tendency on this forum to attribute everything as a symptom of the treatment. One fellow traveler here went to the doctor and discovered she has pneumonia.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline Ruthie

  • Member
  • Posts: 105
Re: 6 days on Harvoni-very bad side effects
« Reply #7 on: March 22, 2015, 10:22:11 pm »
It's best to get checked by your doctor, just in case it's something else. However, if it's not something else, there's a chance it's Harvoni. I've completed 6 weeks of Harvoni and still have nausea and diarrhea every day, plus headaches, anxiety,  mental fog, and fatigue. People on here have reported flu like symptoms that don't last long.

Keep drinking water and ask about phenergin or Zofran for your stomach. Try to eat light. Peppermint or ginger tea are also good for nausea and diarrhea. You can take ibuprofen or Tylenol for aches and pains.

I hope you feel better soon!

Offline bud345

  • Member
  • Posts: 7
Re: 6 days on Harvoni-very bad side effects
« Reply #8 on: March 23, 2015, 09:12:16 am »
Going on my 3rd week and side effects are minimal. I saw my doctor on Friday after 2 weeks on Harvoni and he said it was too soon to check my viral load. I was finally able to go to the gym and take a spinning class to get moving again. I see some people have the side effects come back after 4 to 6 weeks???? Wow...

Offline Ruthie

  • Member
  • Posts: 105
Re: 6 days on Harvoni-very bad side effects
« Reply #9 on: March 23, 2015, 09:30:57 am »
I'm Glad your side effects have become minimal. That's a good thing!

Everyone is different on their side effects. It's hard to tell how each of us will react. I can say for myself that some of mine went away. The Ones that stayed haven't gotten worse. If anything, I'm used to them now and just deal with it. I did get a couple new ones, but those have gotten better with time.

Here's hoping you continue on this path of minimal sides!

Offline atomic dog

  • Member
  • Posts: 160
Re: 6 days on Harvoni-very bad side effects
« Reply #10 on: March 24, 2015, 10:36:37 am »
bud345, glad things have settled down. As I mentioned, I had similar side effects, but they pretty much disappeared after 2-3 weeks (I'm on Week 6). I still get things, tiredness and whatnot, but I know it's all transient and I try not to stress. Keep your eyes on the prize (end of treatment and that key 12 week followup). Hep C has taught me patience and Harvoni is reinforcing that lesson.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline bud345

  • Member
  • Posts: 7
Re: 6 days on Harvoni-very bad side effects
« Reply #11 on: March 24, 2015, 11:33:00 am »
Patience has never been one of my strong points lol. I'm glad things have settled down with me and like you I still feel some tiredness but also like you I'm not stressing it. Been thru too much in life to worry now! Warmer weather is coming and a chance to get outdoors will make any side effects less problematic.
I must say that this blog has been helpful in that I don't feel alone taking a drug that's new. Thanks to all!

Offline chino1969

  • Member
  • Posts: 117
Re: 6 days on Harvoni-very bad side effects
« Reply #12 on: March 25, 2015, 12:14:40 pm »
I've started my 5th week on Harvoni out of a 24 week regimen.  My side effects are not noticeable.  The first two weeks+ I experienced mild headache, etc. but nothing now.  I forced myself to start working out again and I think this has helped.  Just had my 4 week labs done and am waiting on results.  I drink at least a gallon of water every day.

Offline lporterrn

  • Member
  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: 6 days on Harvoni-very bad side effects
« Reply #13 on: March 25, 2015, 12:49:58 pm »
Just a reminder, that sometimes flu-like symptoms are caused by things other than HCV treatment. We can get so wrapped up in treatment that we might overlook the fact that all around us, people get stomach viruses, mild food poisonings, the flu, etc. I've been there. For a week I blamed a rash on ribavirin  - it was poison oak. And I am a nurse, so if I did it, I bet others have too.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline CHepCFree

  • Member
  • Posts: 66
Re: 6 days on Harvoni-very bad side effects
« Reply #14 on: April 02, 2015, 12:38:47 pm »
Please report all your side effects to FDA and to Gilead.  That is the only way the company knows.  This is a new and powerful drug and we need to help them to help us be informed consumers.  I have finished my treatment (waiting for SRV test) and now seem to have permanent tinnitus, brain fog and dizziness.   I'm hoping this will diminish over time but only time will tell. 

Offline Mike Conwell

  • Member
  • Posts: 43
Re: 6 days on Harvoni-very bad side effects
« Reply #15 on: April 04, 2015, 09:15:22 am »
I have 10 pills left out of 84. I don't know anything about this loose stool thing because I haven't had it. The flu like feeling I had bad for awhile. I have joint aches and headaches. I'll be glad when the last 10 days pass. I've been no VL since week 8. The side affects seem to come at different times during tx.

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: 6 days on Harvoni-very bad side effects
« Reply #16 on: April 08, 2015, 05:00:58 pm »
No sides to report just run down feeling from anemia due to Ribavirin. Other than that working full time, taking one college class and just mowed my lawn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline RDS2

  • Newbie
  • Posts: 1
Re: 6 days on Harvoni-very bad side effects
« Reply #17 on: February 23, 2016, 12:25:24 pm »
The second day on Harvoni I felt good, but I was coming off a flu bug.  I also noticed my eyes were a bit more sensitive to light.  A week later I noticed that the age spots on the back of my hand had faded and my skin felt softer.  I also felt healthier and stronger.  After the fist month, my blood test came back with a viral count of fifteen. I asked the nurse if it were fifteen thousand, and they said, no; fifteen, not fifteen thousand. Before that the count was twenty three thousand. I have not had much diarrhea, but I have been eating yogurt as a preventative.  I also normally eat salads and raw fruits, and a few other healthy things.

Offline jakas

  • Member
  • Posts: 265
Re: 6 days on Harvoni-very bad side effects
« Reply #18 on: February 23, 2016, 02:29:03 pm »
great its working for you :) update your signature its easier to know more details about your tx
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

 


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