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Author Topic: 6 week Harvoni trial shows lower VL responds better  (Read 8971 times)

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Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
6 week Harvoni trial shows lower VL responds better
« on: March 10, 2016, 07:21:55 pm »
http://www.croiwebcasts.org/console/player/29747?mediaType=slideVideo&

So many have speculated that lower viral loads may respond better than higher ones.  Only 26 in this study...all male.  So higher VL's may get longer tx in the future.  Also, treatment naive low VL folks might opt for 6 weeks.  Over 7 million was considered the high mark in this study. They followed participants through SVR12.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: 6 week Harvoni trial shows lower VL responds better
« Reply #1 on: March 15, 2016, 12:54:59 pm »
Thanks Beto, there is still much, much to learn about treating this disease.  We are the "pioneers"........ FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline morab

  • Member
  • Posts: 232
  • Lives in the woods
Re: 6 week Harvoni trial shows lower VL responds better
« Reply #2 on: April 23, 2016, 07:34:05 pm »
So why do we have to take 12 weeks of Harvoni? Instead of 8? My F score was 0.66 and viral load is at around 600 thousand and not to the millions like others I see? I have read about 8 week treatments and wonder, Is the drug company trying to sell more drugs by doing this? Or does it actually take 12 weeks to work?
Curious
3/2016 G 1a
Alt 84
Ast 62
Fibrosis score lab 0.66
quantitation 894,670
4/23/16 day 6, naive Harvoni 12 week treatment
5/27/16 week 4 lab results UNDETECTED AST 23 ALT17

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: 6 week Harvoni trial shows lower VL responds better
« Reply #3 on: April 25, 2016, 12:12:25 pm »
Hey Morab, they are still figuring out the best length of treatment.  Some studies show a shorter time, while others are showing a longer time.  Right now the AASLD is recommending 8 wks. of treatment cautiously, until further studies can verify. The research will determine this, not the drug companies. Personally, I am very glad to have gotten 12 weeks, vs. 8, for the level of info we currently have. For instance, Merck found with their new drug, Zepatier, that if certain RAVs were found prior to treatment, a longer treatment time of 16 weeks was recommended.  They are working diligently on getting this figured out.
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline morab

  • Member
  • Posts: 232
  • Lives in the woods
Re: 6 week Harvoni trial shows lower VL responds better
« Reply #4 on: April 25, 2016, 01:05:03 pm »
Future Thinker,
After talking to Gilead/Harvoni, she said the Dr. prescribing determines the dose. But that with 12 weeks you odds of a cure are just enough higher to make sure of a total cure.
So 12 weeks I go!
Yesterday I suffered severe depression but today that is gone.
Like everyone is saying each day is different and I really look forward to being cured!
I am planning a major detox regime after taking the drug to cleanse my whole body and revive my liver.
Thanks again for all the support.
This forum is the only support I am getting as the Gastro Dr. I saw was not helpful at all nor are his staff.
3/2016 G 1a
Alt 84
Ast 62
Fibrosis score lab 0.66
quantitation 894,670
4/23/16 day 6, naive Harvoni 12 week treatment
5/27/16 week 4 lab results UNDETECTED AST 23 ALT17

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: 6 week Harvoni trial shows lower VL responds better
« Reply #5 on: April 25, 2016, 02:20:47 pm »
Morab, so glad to hear today is better, just take it one day at a time and before you know it, weeks will have gone by! Keep focused on that goal of SVR.

I agree with Gilead in that the doctor determines the dose; what I was talking about is that the doctor determines your dose based on the research.  And a lot of research is still in the works on these drugs, as they are so new. I predict that in the near future, the screening process prior to starting treatment will be more personalized to our individual body's makeup.  Lots more to learn, including the best length of treatment.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

 


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