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Author Topic: Long term post Harvoni  (Read 13209 times)

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Offline BubbaT

  • Member
  • Posts: 267
Long term post Harvoni
« on: April 19, 2015, 12:22:48 am »
Are there any Long term/ or short term studies on on previous hepc patients who took Harvoni?   Since FDA approval was October 2014, and the previous trials were conducted I assume last year.

Does anyone have in links they could post.



Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: Long term post Harvoni
« Reply #1 on: April 19, 2015, 12:41:34 am »
Great question BubbaT.
Some of our forum family who were on clinical trials are still being followed and might be for up to 5 years.


I have wondered if we are, in way, the long term study :o
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Long term post Harvoni
« Reply #2 on: April 19, 2015, 02:03:15 am »
Just can't bring myself to worry about long term effects of any medication to treat hep c.

I must treat I have no choice. The danger of early death due to cirrhosis is the only long term effect I am concerned with. No matter what effects I maybe could have from my treatments are of much less concern to me than my liver disease.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Sam1224

  • Member
  • Posts: 62
Re: Long term post Harvoni
« Reply #3 on: April 19, 2015, 10:04:52 am »
I hear you Lynn K. While it is worthwhile keeping an eye out for long term stuff that might be of concern, the condition of the liver is a immediate concern. More so for some than others. I occasionally wonder about long term effects but then take the pill. Just hoping to there. Good luck to all.

Offline Bituman

  • Member
  • Posts: 157
Re: Long term post Harvoni
« Reply #4 on: April 19, 2015, 05:26:55 pm »
What Lynn said...
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

 


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