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Author Topic: So when it says "take with or shortly after food" ...  (Read 8308 times)

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Offline Philadelphia

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So when it says "take with or shortly after food" ...
« on: March 26, 2015, 04:59:21 pm »
What exactly do you think that means? Is a piece of fruit "food"? A muesli bar? A handful of trail mix? Or do they mean something more substantial?
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline lporterrn

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Re: So when it says "take with or shortly after food" ...
« Reply #1 on: March 26, 2015, 05:03:58 pm »
It depends. Which drug are you referring to?
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Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Philadelphia

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Re: So when it says "take with or shortly after food" ...
« Reply #2 on: March 26, 2015, 05:14:18 pm »
The whole Viekira pak/ribivarin shebang. But particularly the sticker is on the Ombitasvir/ritonavir/paritaprevir combo. Not sure if it's specific to that tablet or the whole cocktail though.
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CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline sapphire101

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  • Posts: 238
  • "Stop worrying and start living"
Re: So when it says "take with or shortly after food" ...
« Reply #3 on: March 27, 2015, 12:44:42 am »
Per my ProCeed nurse 'take with food' means any type of food not the amount. Even crackers to get digestion started because our meds start working in the stomach. I usually go with meals breakfast and dinner because it is easiest and use crackers in a pinch.

Food first can also help prevent nausea.

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Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline lporterrn

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Re: So when it says "take with or shortly after food" ...
« Reply #4 on: March 27, 2015, 06:46:02 pm »
This is from the labeling info: ...take with a meal without regard to fat or
calorie content.

If you want more detail:
Relative to fasting conditions, administration of ombitasvir, paritaprevir, ritonavir, and dasabuvir with a moderate fat meal (approximately 600 Kcal, 20-30% calories from fat) increased the mean AUC by 82%, 211%, 49%, and 30%, respectively.
Relative to fasting conditions, administration of ombitasvir, paritaprevir, ritonavir, and dasabuvir with a high fat meal (approximately 900 Kcal, 60% calories from fat) increased the mean AUC by 76%, 180%, 44%, and 22%, respectively.
Ombitasvir, paritaprevir, ritonavir, and dasabuvir should always be administered with a meal.

AUC is Area Under the Curve, and it basically means how much drug is available to the body. When I read this, my inner voice tells me to take my pills with an ordinary meal that has no more than 30% fat, since my body doesn't need any extra fat, and the AUC is hearty at that percentage. 
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Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline atomic dog

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Re: So when it says "take with or shortly after food" ...
« Reply #5 on: March 28, 2015, 09:55:27 am »
Lucinda, what about Harvoni? I take it with my other meds on an empty stomach, drink 4 oz of what or so and eat 30 mins later. Is that the right regimen?
Logged
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline lporterrn

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Re: So when it says "take with or shortly after food" ...
« Reply #6 on: March 29, 2015, 11:48:15 am »
Atomic Dog - Harvoni can be taken with or without food - it doesn't matter. Some docs are suggesting not taking it with grapefruit, but I have not seen any data on this.
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Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline atomic dog

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Re: So when it says "take with or shortly after food" ...
« Reply #7 on: March 29, 2015, 12:53:57 pm »
thx
Logged
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT
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