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Author Topic: Current hep C origin theory is that it may have come from horses...  (Read 10443 times)

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Offline Hep Editors

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    • Hep Mag
While the virus found in horses is similar to the hepatitis C virus, the scientific evidence linking it to hepatitis C is still far from clear.  Where the virus originated in humans, however, is on more solid ground—West Africa. 

So, how did HCV develop into such a huge problem, infecting an estimated 130-150 million people worldwide?  How did genotype 1 become the most common genotype of hepatitis C in the world?

« Last Edit: April 03, 2015, 12:32:02 pm by Hep Editors »

Offline davidsconfused

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What I have been curious about and can't find info on is how HCV spread before injections and blood transfusions. It's evidently just not that easy to get without direct blood to blood contact. I've had it for 40 years, been married almost 38 years and my wife doesn't have any antibodies for it.

Offline Mike

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Re: Current hep C origin theory is that it may have come from horses...
« Reply #2 on: April 04, 2015, 12:44:05 pm »
The general consensus is that HCV spread through sexual activities, poor hygienic practices and poor medical practices (blood letting, nonexistent universal precautions et. al.), which were prevalent world-wide prior to the 20th century.

As medicine advanced with the advent of the hypodermic needle, transfusions and so on, transmission of the virus exploded from small, isolated pockets to the world-wide population. This was accelerated by world travel, war and so on.

Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline atomic dog

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Re: Current hep C origin theory is that it may have come from horses...
« Reply #3 on: April 05, 2015, 10:00:08 pm »
Also reportedly spread through snorting heroin and coke, since the fine capillaries that line the nasal passages are an easy entry point. Good article.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline Philadelphia

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Re: Current hep C origin theory is that it may have come from horses...
« Reply #4 on: April 05, 2015, 10:15:14 pm »
Darn horses. They've taken all my time, my money, and my weekends. Now I can blame them for the hep c as well.

Off to pick up more manure ...
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013


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