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Author Topic: Second month on Harvoni  (Read 16189 times)

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Offline Israel

  • Member
  • Posts: 8
Second month on Harvoni
« on: April 07, 2015, 12:10:48 am »
I've been on Harvoni for over 3 weeks now.  Tomorrow I'll be getting some lab work done to determine my progress.  Next Friday, 9 Apr, I start my second month on Harvoni and hopefully I can kick this in the butt.  I will post my latest lab results as soon as I get them.  It's not over, 'til it's over.  Good luck to everyone and God bless.

Israel, Orlando, Fl
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Offline lking

  • Newbie
  • Posts: 2
Re: Second month on Harvoni
« Reply #1 on: April 15, 2015, 06:30:52 pm »
How was your 4 weeks test.  Can you tell it is working?
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Offline Israel

  • Member
  • Posts: 8
Re: Second month on Harvoni
« Reply #2 on: April 15, 2015, 08:51:19 pm »
Lab results revealed that my Hep C is undetected!  Amen.  Working on my second month and things are going smoothly.
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Offline badbradley

  • Member
  • Posts: 294
Re: Second month on Harvoni
« Reply #3 on: April 16, 2015, 08:26:03 pm »
Quote from: Israel on April 15, 2015, 08:51:19 pm
Lab results revealed that my Hep C is undetected!  Amen.  Working on my second month and things are going smoothly.
Great news Israel! Best wishes for the future SVR's!
Logged
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline KC

  • Member
  • Posts: 46
Re: Second month on Harvoni
« Reply #4 on: April 23, 2015, 10:02:39 am »
Going on week 6 (Harvoni) and feeling stronger everyday! "UNDETECTED" week 5  8)

Good luck....it really works!
Logged
2/16/15                                     
2/16/15     VL:  3,577,985           
AST:  81  ALT: 94
Fibrosis: F1 - F2
3/18/15:  Began Harvoni  (12 week treatment)
4/16/15: VL "UNDETECTED" <15
ALT: 29   AST: 30
14 weeks post TX UNDETECTED
23 weeks UNDETECTED

Age 59
DX early 90's

KC

Offline red

  • Member
  • Posts: 10
Re: Second month on Harvoni
« Reply #5 on: May 26, 2015, 01:55:15 pm »
I'm on my second month of Harvini and I am setting in dr office now. My white blood count is 20,000. Normal is 5,000. My GI Dr said I have an infection an may have to quit taking harvoni.
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Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Second month on Harvoni
« Reply #6 on: May 26, 2015, 06:49:47 pm »
Sending you good vibes, Red.  ~ ~ ~ ~

It may very well be unrelated.  Hang in there.
Logged
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline red

  • Member
  • Posts: 10
Re: Second month on Harvoni
« Reply #7 on: May 28, 2015, 11:52:19 am »
Thanks for the good vibes Else. I drank lots and lots of water and my second set of lab results showed everything in normal range. Also, my hep c is undetected and my viral load is 3000. However, my Dr wants labs every week now since renal failure is the biggest problem with taking Harvoni. I thank God that everything looked OK and I can continue taking Harvoni. :)
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Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Second month on Harvoni
« Reply #8 on: May 28, 2015, 11:52:41 pm »
I didn't know that renal failure was a significant risk with Harvoni.  Ack.  And just when I thought I'd read everything.  :(
Logged
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Second month on Harvoni
« Reply #9 on: May 29, 2015, 05:26:30 am »
I haven't seen any issues with renal impairment from Harvoni just if you already have renal problems you have to be cautious

http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf

From the prescribing information for Harvoni about use in specific populations

8.6 Renal Impairment
No dosage adjustment of HARVONI is required for patients with mild or moderate renal impairment. The safety and efficacy of HARVONI have not been established in patients with severe renal impairment (eGFR <30 mL/min/1.73m2) or ESRD requiring hemodialysis. No dosage recommendation can be given for patients with severe renal impairment or ESRD [see Dosage and Administration (2.2) and Clinical Pharmacology (12.3)].
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline red

  • Member
  • Posts: 10
Re: Second month on Harvoni
« Reply #10 on: May 29, 2015, 12:42:36 pm »
I don't have kidney problems. When my white blood count was so high, my kidney panel wasn't normal and my GI Dr said that renal failure was the downfall from taking Harvoni so I was just posting what she said. Anyway, all my functions are normal again, so all is good
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Offline red

  • Member
  • Posts: 10
Re: Second month on Harvoni
« Reply #11 on: May 29, 2015, 12:44:36 pm »
Lynn, I also read what you posted from the Harvoni site about renal problems
Logged

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: Second month on Harvoni
« Reply #12 on: May 29, 2015, 01:00:50 pm »
Glad to hear your results are normal now

I have a friend who has kidney disease and hep c and looking at treatment. I personally don't know much about that issue and wish I did for my friend.

I haven't seen anything about Harvoni being a specific problem do you have any info about that where to look up that information?

Thanks
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline red

  • Member
  • Posts: 10
Re: Second month on Harvoni
« Reply #13 on: May 29, 2015, 01:05:00 pm »
No Lynn, sorry I don't. Like I said, I was repeating what my GI Dr told me. Make sure your friend researches it thoroughly before starting Harvoni, and best of luck.
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Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Second month on Harvoni
« Reply #14 on: May 29, 2015, 03:39:27 pm »
It looks like cardiac issues/meds are the only well-documented contraindications.  But it's a new drug.  The volume of post-FDA approval events is bound to increase.

Having said that, I still wish I could start it tomorrow.  This waiting game is driving me nuts.  The "staging priorities" policy of my insurance company is so damn perverse.  They want to see proof of major organ damage before authorizing treatment.

Still shaking my head in disbelief.  Can you imagine if they pulled this with any other disease?  Required a diabetic to go blind or an epileptic to have x number of documented seizures?  Freakin' medieval it is.  >:(
Logged
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)
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