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Author Topic: SVR12!  (Read 14155 times)

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Offline dragonslayer

  • Member
  • Posts: 873
SVR12!
« on: April 10, 2015, 04:22:33 pm »
For all those who had low detectables at EOT, here's real world proof, along with the study published in the Oxford Journal referred to on these pages.. Just got a call from my doctor.. Undetected at 11 wks post treatment,  which shall serve as my SVR12 result. This, after testing Detected 29 at EOT!  I havent seen the lab paper result yet with my own eyes, but for now, this will more than suffice!!   We shall restest at 24 wks and again at 48 just to make sure late relapse isnt occurring, but this is about the best news I could get.. I even got official permission to go have a beer!

So, Katie, Dee Dee, and anybody else testing low level detected at EOT... Your day shall come soon!

Thanks to everyone who convinced me not to jump to negative conclusions due to my low detected result at EOT. You helped me immeasurably keep the faith and wait for future labwork, which wound up belying the EOT result.

Best of luck to everyone here.. Harvoni really is a miracle worker.
« Last Edit: April 10, 2015, 04:37:17 pm by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline charly8

  • Member
  • Posts: 113
Re: SVR12!
« Reply #1 on: April 10, 2015, 04:52:23 pm »
This is wonderful news.  It is truly a real world example of what we have been talking about. 

Congrats, enjoy the beer. You deserve it.
1a, VL  1.05 Mil, ALT 47
Fibrosure F3 December 2014
Fibroscan F0-F1 March 2015
1995 INT & RYB -non-responder
2007 PEGIN & RYB 72 weeks tx - partial responder relapsed
1/23/15 Started Harvoni 12 weeks, EOT 4/17
2 week blood work -  <15 Und. (ALT 25)
4 week blood work - <15 Und. (ALT 29)
2/20/15 added RYB (4 weeks into 12 of tx)
8 week blood work - <15 Und. (ALT 23)
(EOT) 12 week blood work - <15 Und.
4wk POST tx VL - Und. (ALT16, AST 17)

Offline kate0b1

  • Member
  • Posts: 293
Re: SVR12!
« Reply #2 on: April 10, 2015, 05:43:15 pm »
OMG paul, i am so excited for you. This is the best thing i saw today  8)

kate

Offline Momof3

  • Member
  • Posts: 55
Re: SVR12!
« Reply #3 on: April 10, 2015, 07:57:54 pm »
Wow that is awesome!!! Congrats to you!!
Hep c GT 1a from transfusion at birth 1986
Treatment naive
Stage f0-f1 fibroscan score 2.5kpa
Harvoni started 02/11/2015 8 weeks
Baseline VL 689,594 ALT 35 AST 25
2 weeks ALT 13 AST 16
4 weeks VL <15 detected ALT 12 AST 15
 UNDETECTED  at EOT April 7
4 weeks post Harvoni UNDETECTED ALT 10 AST 14
12 weeks post Harvoni UNDETECTED ALT 8 AST 15
24 weeks post Harvoni UNDETECTED ALT 13 AST 18

CURED!!!!

Offline Long_Haul

  • Member
  • Posts: 161
  • Slayed the Dragon
Re: SVR12!
« Reply #4 on: April 10, 2015, 08:07:58 pm »
Paul great news, I knew good news was coming for you! JillLyn and you getting the SVR12 in the same day is unbelievable. Enjoy the beer and you can drop the shoulders and know you slayed the beast!

Best wishes,


AL
Genotype 1A

Diagnosed 1989
Biopsy-cirrhosis stage 4 2000, no starting VL this round

3 rounds of Int+Rib
(Combo/48wks,Peg/26 Wks,Triple with Incivek/16wks)
UND with Incivek, Relapsed
Started 12 weeks Harvoni and Rib Jan 2nd,2015
4 weeks Undetected
8 weeks Undetected!
EOT at 12 weeks Undetected
EOT at 24 weeks STILL UNDETECTED
Completed TX Mar 26th,2015

EOT plus 4 weeks UNDETECTED
EOT plus 12 weeks UNDETECTED !!!!!!!!!!! I am DONE!

NO LONGER a member of the "WAITING GANG"

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: SVR12!
« Reply #5 on: April 10, 2015, 10:00:55 pm »
We have heard about this phenomenon on forum posts and even got it straight from some of our Moderators and had access to official links to scholarly articles and still it seemed too good to be true. 


This is the proof to me because it happened for Dragonslayer. Thank you thank you for posting and congratulations. I can not even imagine the stress you have been through while waiting eleven weeks and not knowing.


Enjoy that beer for all of us. Cheers!
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline Bituman

  • Member
  • Posts: 157
Re: SVR12!
« Reply #6 on: April 10, 2015, 10:10:16 pm »
Great work Paul.  You truly did slay the dragon!  Indeed, Harvoni is a miracle worker.  All the best.

Bob
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline JoeK9999

  • Member
  • Posts: 88
Re: SVR12!
« Reply #7 on: April 11, 2015, 06:46:41 am »
NOT DETECTED  - SVR12
I got my call late yesterday afternoon from the doctors office about my 12 week
post Harvoni test.
Not Detected and all other tests normal. Thrilled, ecstatic!
I started 12 weeks of Harvoni just 2 weeks after the FDA approved it.

It worked. I have been on pins and needles since my last HVC test was done one month into treatment and it was detected at that time.
Paul (dragonslayer) - Congratulations on your results. New life.
Diagnosed July 1995 - Genotype 1a
Think I have I had since the early 70's
Prior to Harvoni treatment:
VL 3.8 million AST/ALT 40/56
Mild inflammation, no fibrosis
Treatment naive
 
Started Harvoni 10/23/2014 for 12 weeks
11/20/2014  HCV RNA Qual - Detected
Last Day of Harvoni 01/15/2015
04/08/15 - 12 week post harvoni VL test - Not Detected
07/05/15 - 24 week post harvoni VL test - Not Detected
01/19/16 - 1 Year  post harvoni VL test - Not Detected
AST/ALT 22/22
CURED!!

Offline Long_Haul

  • Member
  • Posts: 161
  • Slayed the Dragon
Re: SVR12!
« Reply #8 on: April 11, 2015, 09:03:05 am »
Congrats to you JoeK. Time to finally let go a relax, the dragon is gone!  So happy to see all of these SVR news, there is hope for the rest of us.

Best wishes,
AL
Genotype 1A

Diagnosed 1989
Biopsy-cirrhosis stage 4 2000, no starting VL this round

3 rounds of Int+Rib
(Combo/48wks,Peg/26 Wks,Triple with Incivek/16wks)
UND with Incivek, Relapsed
Started 12 weeks Harvoni and Rib Jan 2nd,2015
4 weeks Undetected
8 weeks Undetected!
EOT at 12 weeks Undetected
EOT at 24 weeks STILL UNDETECTED
Completed TX Mar 26th,2015

EOT plus 4 weeks UNDETECTED
EOT plus 12 weeks UNDETECTED !!!!!!!!!!! I am DONE!

NO LONGER a member of the "WAITING GANG"

Offline JoeK9999

  • Member
  • Posts: 88
Re: SVR12!
« Reply #9 on: April 11, 2015, 09:08:12 am »
Thanks AL.
Based on your results I would call you cured too.
Give it a few months off the the drugs and you will start feeling like a million dollars!
It took me about 8 weeks before all the crap wore off I and am feeling great now.
Cure for all!
Diagnosed July 1995 - Genotype 1a
Think I have I had since the early 70's
Prior to Harvoni treatment:
VL 3.8 million AST/ALT 40/56
Mild inflammation, no fibrosis
Treatment naive
 
Started Harvoni 10/23/2014 for 12 weeks
11/20/2014  HCV RNA Qual - Detected
Last Day of Harvoni 01/15/2015
04/08/15 - 12 week post harvoni VL test - Not Detected
07/05/15 - 24 week post harvoni VL test - Not Detected
01/19/16 - 1 Year  post harvoni VL test - Not Detected
AST/ALT 22/22
CURED!!

 


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