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Poll

Has any tx naive Pt. been diagnosed with calcified tendonitis after tx with Harvoni monotherapy?

Yes
0 (0%)
No
4 (100%)

Total Members Voted: 4

Voting closed: October 06, 2017, 01:27:54 pm

Author Topic: post Harvoni monotherapy treatment naive  (Read 8464 times)

0 Members and 1 Guest are viewing this topic.

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
post Harvoni monotherapy treatment naive
« on: July 08, 2017, 01:27:54 pm »
Just collecting a poll based on Gilead Canada released Harvoni monograph side effects.
Tendonitis in most people can be self-limiting and resolve itself. HCV itself, has been linked to joint problems. I'm curious to know how many, if any, have been diagnosed with calcified tendonitis, and or tendinosis who were otherwise without this condition prior to treatment.
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: post Harvoni monotherapy treatment naive
« Reply #1 on: July 08, 2017, 03:02:14 pm »
-have had joint pains for decades (both before and after Harvoni) but they have always been presumed connected to autoimmune disease. Based on this page:
http://www.webmd.com/a-to-z-guides/tc/calcium-deposits-and-tendinitis-calcific-tendinitis-topic-overview
"calcific tendinitis" is unlikely to be what I have, so I have voted no.

D63, my sympathy if you are suffering from this particular joint problem.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lynn K

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  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: post Harvoni monotherapy treatment naive
« Reply #2 on: July 10, 2017, 01:34:37 am »
Nope
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Teneg

  • Member
  • Posts: 3
Re: post Harvoni monotherapy treatment naive
« Reply #3 on: July 12, 2017, 09:05:09 am »
Hi Lynn
Congrats on your cure.  Sorry for your current issue.  I am about to start Harvoni. " I think". Still waiting on pre-test results and waiting to hear from Doc.  I have noticed on a lot of the post that after 4 weeks a lot of folks are clear.  The ALT and AST are down to normal.  So why do they continue the meds sometimes for an additional 4 weeks or more sometime?  Just curious. Why they do that. Thanks for any input you can give me on this.  Thank You Very Much.
Again Congrats to You.
Wishing you Well.

Offline Lynn K

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  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: post Harvoni monotherapy treatment naive
« Reply #4 on: July 13, 2017, 01:56:48 am »
While the virus is not detected at 4 weeks for many patients that does not mean the virus is gone it is only below the tests ability to detect its presence.

 So treatment will continue for at least to the 8 week point or 12 weeks to ensure the virus is totally eridicated.

I treated with Sovaldi and Olysio for 12 weeks and was not detected at 4 weeks and at EOT (end of treatment) but when I was tested again 12 weeks after my treatment had ended I was back up to pre treatment viral load of 2.4 million.

So with that failure, plus my 3 prior failed treatments with interferon based treatment and the fact I have liver cirrhosis my last treatment was 24 weeks of Harvoni to which we added ribavirin part way in at week 9 so I took ribavirin for 15 weeks of my 24 weeks of Harvoni. This was to ensure my odds of finally curing my hep c.

Just like when you take an antibiotic and feel better in a few days you still need to finish your full course of meds.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Teneg

  • Member
  • Posts: 3
Re: post Harvoni monotherapy treatment naive
« Reply #5 on: July 13, 2017, 07:39:23 am »
Hi Lynn
Thank you for getting back to me so soon.  Again CONGRATS!  I appreciate the information you have shared.  I am still waiting to hear. I am really hoping not to have to use the riba.  I don't know why I just REALLY don't want to.  But again, I have just begun to wait. Dr. and insurance etc.  Just starting my journey.  I will keep you all posted. Thanks so much for the much needed info.  Wishing you health and happiness.

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
Re: post Harvoni monotherapy treatment naive
« Reply #6 on: July 13, 2017, 11:05:33 am »
Hi Teneg! I'm glad you're getting started. I bet you're excited. Lynn K is right. They need you on it after undetectable "UD" to be sure the meds are getting anything still lurking, if there is anything. I'm guessing you're waiting on your VL- viral load count & perhaps what GT genotype you are? It's good to ask for copies of labs to take home. If you feel okay about it, post your stats on your profile too. It helps! Wishing you a smooth ride into tomorrow, Teneg  :)
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: post Harvoni monotherapy treatment naive
« Reply #7 on: July 13, 2017, 11:24:28 am »
Unless you are a multiple treatment failure with cirrhosis if you take Harvoni you won't have to take riba.

If you are given viekira Pak and have genotype 1a you would take ribavirin along with viekira Pak but that is the only reason I know of that someone without liver damage and not a multiple treatment failure would have to take riba

Good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Teneg

  • Member
  • Posts: 3
Re: post Harvoni monotherapy treatment naive
« Reply #8 on: July 13, 2017, 01:30:19 pm »
Thanks D63 and Lynn.  The information is invaluable.  As I said in an earlier post. Still waiting on test results and to hear from Doc.  I know he was getting a viral load, RNA etc.  No word yet. That was last Friday. A week tomm.  So, I still don't know that info. But will share when I find out.  Again, thanks.

 


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