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Author Topic: Allergy Med effective against HCV?!?!?!?!?  (Read 8815 times)

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Offline bridget

  • Member
  • Posts: 36
Allergy Med effective against HCV?!?!?!?!?
« on: April 11, 2015, 09:02:16 pm »
Have you all seen the recent news about studies showing the allergy medicine, HCI to be effective in treating HCV?  This would certainly force Gilead to lower prices. Very interesting! http://www.techtimes.com/articles/45095/20150409/forget-1-000-a-dose-hepatitis-c-drug-this-cheap-allergy-medicine-might-be-as-effective.htm

Offline Bituman

  • Member
  • Posts: 157
Re: Allergy Med effective against HCV?!?!?!?!?
« Reply #1 on: April 11, 2015, 11:13:42 pm »
Sounds interesting, if not promising.  But I hope this doesn't create a situation that resurrects the older IFN based treatments that can be combined with CCZ.  If such a combo was cheaper, then some might be forced into a treatment that, even though effective, is much less well tolerated compared to the current DAA's.  The article is a little imprecise in terms of possible combos.  In any case, I agree with Bridget, it might force downward pressure on price. 

Bob
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline bridget

  • Member
  • Posts: 36
Re: Allergy Med effective against HCV?!?!?!?!?
« Reply #2 on: April 12, 2015, 07:51:41 am »
Good point about the potential risk of insurers promoting Interferon again, that would be horrible.
It seems fair that Gilead's greedy monopoly will be temporary. Generics, competitor & now possibly an allergy medicine will force Gilead to lower prices.

Offline seekir

  • Member
  • Posts: 32
    • Mikey's Island
Re: Allergy Med effective against HCV?!?!?!?!?
« Reply #3 on: April 28, 2015, 01:59:10 am »
I'd like to know more about the potential efficacy and safety of the chlorcyclizine when taken as an anti-viral. According to the clinical trial site (link below), the 28 day trial initiated in March 2014. I'm not sure if that was the actual date they started the drug treatments of the trial participants, but the site says that no information regarding the chlorcyclizine treatment will be released till March of 2017. The daily dosage they're using in the trial seems alarmingly high; about five to six times the maximum for use as an antihistamine.

https://clinicaltrials.gov/ct2/show/NCT02118012
61 yo male
Genotype 1a, treatment naive till 8/6/15 when Harvoni treatment was provided through Gilead's Support Path after health insurer (HMSA) denied Harvoni treatment and appeal due to moderate F1/F2 liver status. Sides very mild, virus "undetectable" at 28 days.

Offline seekir

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  • Posts: 32
    • Mikey's Island
Re: Allergy Med effective against HCV?!?!?!?!?
« Reply #4 on: June 24, 2015, 04:24:38 pm »
Quote
The daily dosage they're using in the trial seems alarmingly high; about five to six times the maximum for use as an antihistamine.

Oops, mistook the Ribavirin dosage for the chlorcyclizine dosage in the trial... The chlorcyclizine dosage they're using is actually slightly less than the max for use as an antihistamine. I believe half of the trial's non-placebo participants are taking Ribavirin with the chlorcyclizine, half just chlorcyclizine. I'm very sorry I've confused the issue. I'm still hoping to hear good news about the efficacy of chlorcyclizine as HCV therapy.
« Last Edit: June 24, 2015, 04:29:29 pm by seekir »
61 yo male
Genotype 1a, treatment naive till 8/6/15 when Harvoni treatment was provided through Gilead's Support Path after health insurer (HMSA) denied Harvoni treatment and appeal due to moderate F1/F2 liver status. Sides very mild, virus "undetectable" at 28 days.

 


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