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Author Topic: harvoni test results at week 5  (Read 14802 times)

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Offline Corey

  • Member
  • Posts: 31
harvoni test results at week 5
« on: April 13, 2015, 06:29:55 pm »
Another Harvoni report from Genotype 1a.  Started in early March with a VL around 6million.  At the end of 5 weeks, my latest results are below detection limits.  Good news for spring.  Hope that those last little ba$t@rds are wiped out within a few more weeks. 

Good luck to everyone else on treatment!

Logged

Offline BubbaT

  • Member
  • Posts: 267
Re: harvoni test results at week 5
« Reply #1 on: April 13, 2015, 09:44:06 pm »
Great news Corey!
Kill em all!
Logged
Age 57 male
Infected late 70's
Diagnosed 95
1a, 2 prev biopsy 95, 2004
Ct 2007, 2015
Treatment Naive
F4 A3. Fibrosure/ CT 2-5-15. Ammonia 222
VL 2.2 mil.
Started Harvoni  3-3-15. 12weeks, finished 5-26-15
4 week VL undetected
12 week EOT undetected

Offline Anita13

  • Member
  • Posts: 14
Re: harvoni test results at week 5
« Reply #2 on: April 14, 2015, 08:46:48 am »
Great! It seems week 5 or 6 is the breaking point for many. My husband was 4 million at the start, then week 2 76, week 4 <15 and week 6 UD. Hope it lasts for you all the way to the end and beyond. Congrats!
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Offline Corey

  • Member
  • Posts: 31
Re: harvoni test results at week 5
« Reply #3 on: April 14, 2015, 08:50:58 am »
Thanks all.  This is the first blood test that I have had since starting.  Are others testing on a weekly basis?  Just curious as this appeals to me as a science geek to watch the virus levels in a death spiral.... :)
Logged

Offline Mike

  • Member
  • Posts: 999
Re: harvoni test results at week 5
« Reply #4 on: April 14, 2015, 09:06:24 am »
Great news, Corey!

Best wishes, Mike
Logged
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: harvoni test results at week 5
« Reply #5 on: April 15, 2015, 05:56:38 am »
Congrats Cory

Tested at week 4 and week 12 next viral load week 24 EOT then 4 weeks post and 12 weeks post. I think the doctor is going to do a 24 weeks post and maybe 1 year.

I was virus not detected ar week 4
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline GLCII

  • Member
  • Posts: 127
Re: harvoni test results at week 5
« Reply #6 on: April 16, 2015, 11:29:11 am »
Ho Corey

I test every two weeks. Every other thursday. Just did my second two week test (4 weeks) last thursday the 9th. My doc @ Henry Ford Hospital Detroit Campus put in a standing order so all I have to do is show up. Fortunately for me, I don't have to drive downtown since there is a satalite facility about 3 miles from my house.

Another good thing is that I can access my lab results online. I get an email telling me when the test results come in. I like the idea of being able to see my results, first hand, rather then have to call or wait and get the results. During my last three Tx's I went online and learned what all the test were and how to read them. They can be confusing if you don't know what you're looking at.
Logged
Pre Tx (VL 12043488) ALT 52/ AST 39
Harvoni Start Date 03/12
2 Week in Tx Results HCV RNA Detected, less than 15 IU/mL. ALT 19 / AST 19
4 Weeks in Tx Results HCV RNA Not detected. ALT 21 / AST 18
12 Week in Tx Results HCV RNA Not detected. ALT 17 / AST 19
--------------------------------------------------------------
Post 12 Week EOT Tx ALT 19/ AST 19 (Undetected)
Post 24 Week EOT Tx ALT 19/ AST 15 (Undetected)

Offline debham

  • Member
  • Posts: 68
Re: harvoni test results at week 5
« Reply #7 on: April 16, 2015, 11:45:59 am »
Blood work done the first week of March. Two weeks in next blood work will be at 8 weeks. I'm on a twelve week treatment of Harvoni. I feel much better than I have in years. I'm not sure if it's the medication or if it's I don't have as many toxins flowing threw my body because I'm getting rid of this monkey on my back.  :) But what ever it is I like it.
Logged
Diagnosed 2003
VL 300,000
Geno type 1 a
Start TX 4/01/15
VL 2.3 million
Tx Naive
12 wk Tx
Harvoni
Last Ultra Sound
No presents of fibrosis

Offline sisterbland

  • Member
  • Posts: 18
Re: harvoni test results at week 5
« Reply #8 on: April 21, 2015, 07:19:35 pm »
I started March 17th on Harvoni and just got my 4 week blood test results back. Everything is in normal range and HVC quantitative is undetectable. After 25+ years with HCV, my question is when should I start feeling significantly better? I have had spurts of energy when I feel totally normal which is amazing while it lasts.

So excited to be getting rid of this terrible disease!
Logged
1987/88 Contracted HCV 1a (had acute HepA and HepB in the same 5 year period)
1997 Interferon/ribavirin 7 mo; relapser
3/17/15 Harvoni started, 12 wks
4/17/15 VL <15 IU/ML (Undetected)
6/11/15 Complete tx

Offline atomic dog

  • Member
  • Posts: 160
Re: harvoni test results at week 5
« Reply #9 on: April 27, 2015, 01:59:58 am »
Sisterbland, you're well on you way. My experience is that the Harvoni continues to cause side effects (headaches, tiredness or whatever), so you won't feel clear till you end treatment and then folks say it takes several days for the drug to clear your system). Be patient. I'm starting my last bottle tomorrow. 70 pills down, 14 pills to go.
Logged
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline sabre

  • Member
  • Posts: 77
Re: harvoni test results at week 5
« Reply #10 on: April 27, 2015, 09:31:13 am »
I recall that my doctor said something to the effect of, everyone becomes UND at some point on Harvoni, but SVR12 is the only thing we need to be concerned with. I didn't question him, but I may put a call in to ask if I'm going to have any testing during the 12 week treatment plan. I began treatment on 3/28/15 so I'm just past the 4 week mark.

Has anyone else had a similar experience with their doctor?
Logged
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: harvoni test results at week 5
« Reply #11 on: April 27, 2015, 08:06:15 pm »
Hi sabre

Not myself personally but I have seen a couple of 8 weekers who did no testing till post EOT.

The on treatment tests mean nothing although they are encouraging for us to see. The on treatment test results do not change the course of your treatment.

The only test that matters is the 12 week post. All the on treatment tests do is just make us feel good (or nervous if say your result is less than 15 detected) but our insurance pays about $400 a pop for them and they don't mean anything.

Good luck on treatment
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline sabre

  • Member
  • Posts: 77
Re: harvoni test results at week 5
« Reply #12 on: April 27, 2015, 11:37:56 pm »
Hi Lynn,

Thank you for your input and I agree. I've read enough posts here and on other forums where people are nervous because they're detected at various stages in their treatment. I'd prefer not to ruminate if I were to test, and test detected.

I'm leaning toward just waiting it out and having hope that I'll be one of the majority who achieve SVR.

Best wishes to you as you approach the finish line!
Logged
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: harvoni test results at week 5
« Reply #13 on: April 28, 2015, 10:47:03 am »
Quote from: GLCII on April 16, 2015, 11:29:11 am
Ho Corey

I test every two weeks. Every other thursday. Just did my second two week test (4 weeks) last thursday the 9th. My doc @ Henry Ford Hospital Detroit Campus put in a standing order so all I have to do is show up. Fortunately for me, I don't have to drive downtown since there is a satalite facility about 3 miles from my house.

Another good thing is that I can access my lab results online. I get an email telling me when the test results come in. I like the idea of being able to see my results, first hand, rather then have to call or wait and get the results. During my last three Tx's I went online and learned what all the test were and how to read them. They can be confusing if you don't know what you're looking at.

Lynn- I know you have probably posted this somewhere but why did your DR. add RIBA if you were UND at 4 weeks? Just to double triple make sure it stayed that way?
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: harvoni test results at week 5
« Reply #14 on: April 28, 2015, 12:21:50 pm »
I failed interferon based treatment 3 times as a null responder (my viral load increased on treatment). I relapsed after 12 weeks of Sovaldi and Olysio last year after being not detected at week 4 and EOT. I have liver cirrhosis for over 7 years now with portal hypertension and developed esophageal varicies that had to be banded. I have had hep c for 37 years.

This is basically my last shot at a cure. If this doesn't work why would anything coming later work? I could decompensate basically at any time and need a liver transplant.

I saw a YouTube video of a round table discussion of some hep c experts discussing some of last years AASLD conference highlights. When the came to a situation with a patient like myself they all agreed they would give that patient the best chance of a cure and add Ribavirin.

I sent a message to my doctor and asked about adding riba and she agreed. She also said maybe it would have been an idea to add the Riba from the beginning of tx.

If you look at the study with Harvoni and Ribavirin with child "B" and "C" decompensated cirrhotics they had better results treating them with Ribavirin and actually for decompensated cirrhotics the recommended treatment per the AASLD treatment guidelines is 12 weeks of Harvoni and 600 mg Ribavirin increasing as tolerated.
« Last Edit: April 28, 2015, 12:33:00 pm by Lynn K »
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: harvoni test results at week 5
« Reply #15 on: April 28, 2015, 01:36:05 pm »
My Doctor mentioned RIVA at the beginning also
He said I could do 12 weeks of Harvoni/Riva instead of 24 Harvoni
We didn't want to rock the boat with insurance so he just went with 24 weeks Harvoni.  Now of course I am 2nd guessing everything.

Good luck Lynn.  I wish you the very best and everlasting SVR
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: harvoni test results at week 5
« Reply #16 on: April 29, 2015, 01:58:53 am »
I think you are treatment naive right?

The odds are more in your favor than they are in mine and mine are pretty good!

If I can beat this thing it will just show how darned effective this drug is.

Good luck to you too :)
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: harvoni test results at week 5
« Reply #17 on: April 29, 2015, 04:01:16 pm »
No not treatment naïve.  I took interferon injections a million years ago
Logged
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)
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