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Author Topic: After tx (POST) 4wk or 12 wk SVR results (Harvoni only) - CHECK IN HERE PLEASE!  (Read 707836 times)

0 Members and 5 Guests are viewing this topic.

Offline dragonslayer

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  • Posts: 873
Damn, Katie, thats not a story you hear every day; 'a bear ate my apples!' .. Maybe some barbed wire at the base of the trees?   There must be Something to do.... We mere  mortals contend with rabbits and raccoons,  but you get it all up there!!
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
  And to think I had a problem with 'coons , 'possums , ringtail cats , and armadillos!!!!!!!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Katie

  • Member
  • Posts: 784
Hahahaha...I just take bears in stride and became quite fond of them when I did field research...cautious but fond.  They are eating machines this time of year and I am sure the ripe apples fragrance brings them in for the treat.  The apples were so flavorful this year.  Had some close bear encounters in the field and respect their strength and agility.  For a couple years in a row I didn't get a single apple because of an old black bear that camps out above me.Then no one has bothered them for the past 2 years so I figured he died.  I don't want barbed wire or an electric fence so I just don't worry about it.  They come and go and now my trees are tall enough where the bears can't reach some of the fruit.  I'll share with them and not complain much.  At least he didn't break up the branches which irritates me, and I still got a bucket full. 

Sorry to post this unrelated stuff, but sometimes it is nice just to read a story other than one of Hep C.  We seem to get to know one another here and that's part of building trust and being open with such personal information, so it's fun to share part of my life.

Have a good week, everyone!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Cute

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  • Posts: 34
Hi,
Bixter you have forgotten my mother.

12 week treatment - SVR 10 Undetected.

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Hi Cute

I copied this from the beginning of the thread. Could you enter your moms info in this format as much information as you have and are willing to share?

Please list the following: (copy and paste into your post as I have done below to keep this thread clean)
1. 4wk - 12 wk EOT VL status
2. Treatment duration
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)

What you have so far is

1. 4wk - 12 wk EOT VL status - SVR 10
2. Treatment duration - 12 Weeks
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)

The SVR 10 that is 10 weeks after she completed her treatment correct?

Congrats to you both!
Lynn
« Last Edit: September 28, 2015, 02:26:46 am by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Cute

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  • Posts: 34
1. EOT VL status - SVR 10 - Undetected
2. Treatment duration - 12 Weeks
3. tx naive
4. Genotype 1b
5. F3 fibrosis (february, 2015)
6. Initial VL - 381 000 IU/ml (march,2015)

Offline Cute

  • Member
  • Posts: 34
Hi Cute

I copied this from the beginning of the thread. Could you enter your moms info in this format as much information as you have and are willing to share?

Please list the following: (copy and paste into your post as I have done below to keep this thread clean)
1. 4wk - 12 wk EOT VL status
2. Treatment duration
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)

What you have so far is

1. 4wk - 12 wk EOT VL status - SVR 10
2. Treatment duration - 12 Weeks
3. tx naive or experienced
4. Genotype (1a or 1b)
5. F1-F4 fibrosis status (date)
6. Initial VL (date)

The SVR 10 that is 10 weeks after she completed her treatment correct?

Congrats to you both!
Lynn

Lynn,
Yes, you are correct. SVR 10 means that she completed the treatment 10 weeks ago.

Offline Redbird29

  • Member
  • Posts: 73
  • I've seen the needle and the damage done.....
THANK YOU BIXTER!!!

I know I am one who also appreciates "seeing" the results posted and I feel blessed to be included. SVR4 on my 8 week tx and looking forward to the day we all post SVR12!

Infected - late 70's /early 80's
GT - 1a

Fibrosure 1/2015 - F1-2
TX Naive - Harvoni 8 wks

SOT 6/25/15  VL - 468,000        AST-44  ALT-56       
EOT  8/19/15  VL-  Not Detected AST-21  ALT-30
1 YEAR POST TX - UNDETECTED AST 20 ALT 22
2 YEAR POST TX - UNDETECTED AST 15 ALT 18

Offline Bixter

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  • Posts: 18
Thanks to everyone for your response, it feels good to share with you all.

Cute: I'll add your mums result, thank you for letting me know.

Dragonslayer: I'm sure you are right about jacattac. Just didn't know what to write, that's why I marked it red and added a question mark. I guess I could just as well have written SVR?
Unfortunately we might never know...

Offline dragonslayer

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Thanks to everyone for your response, it feels good to share with you all.

Cute: I'll add your mums result, thank you for letting me know.

Dragonslayer: I'm sure you are right about jacattac. Just didn't know what to write, that's why I marked it red and added a question mark. I guess I could just as well have written SVR?
Unfortunately we might never know...

Bix, I think you posted it correctly.  Its impossible to know anything for sure unless the info is provided to us. .I was just commenting on it because I felt it very unlikely that youd have a viral load < LLOQ at 12 wks post treatment that was any kind of relapse. I think it just doesnt work that way.  At any rate, your amalagamation of the data is very useful, and no small undertaking, since the data on this board is all over the place.

Thanks again!!!
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Rosie13

  • Member
  • Posts: 297
Can you explain LLOQ?
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
technical definition:

The LLOQ refers to the lowest HCV RNA concentration that is within the validated quantitative range of an assay. An undetectable result indicates that HCV RNA was not detected in the sample. The limit of detection and the limit of quantification vary according to the assay used.

Basically the test has the ability to "count" number of virus in a blood sample down to a point the LLOQ. Below that number of virus particles (IU/mL) international units per milliliter of blood the test can still detect the presence of the virus DNA but can't determine how many there are per mL.

So a LLOQ of say 15 for example the test can detect there is virus DNA present in the sample but only knows there are less than 15 IU/mL in the test sample.

And whether those are actual virus cells or just remnants of broken virus cell is hard to say

Hope that helps
« Last Edit: September 28, 2015, 11:11:59 pm by Lynn K »
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline gnatcatcher

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  • Posts: 1,372
Lynn supplied the definition. Here is what the acronym LLOQ stands for:
Lower Limit of Quantification
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Rosie13

  • Member
  • Posts: 297
Thanks Lynn & Gnatty for the explanation. I had not seen that on any of my labs yet so it's good to know.
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Rosie, different labs have different ways of expressing these things. Following the test result there may be a paragraph or more of explanation which may or may not use the LLOQ acronym.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Rosie13

  • Member
  • Posts: 297
Good to know,Gnatty. 4 wk. .labs are Friday!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline baffled5555

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  • Posts: 4
I have a question..Does <12  Not Detected mean the same as undetected??

Offline gnatcatcher

  • Member
  • Posts: 1,372
It almost certainly does mean undetected. It is telling you that that particular assay can't COUNT fewer than 12 international units per mL, but it can still detect some if it is there. Your assay is more sensitive (better) than most assays, which can't count fewer than 15.

Quest Diagnostics, for example, says "<15 Not Detected." The result is followed by some text which includes "For more information on this test, go to <link>"  which includes the following:
A "<15 Detected" means the assay was able to detect HCV RNA but was not able to accurately quantitate the viral load. A "<15 Not Detected" means the assay did not detect HCV RNA . . . .

Congratulations!

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline baffled5555

  • Member
  • Posts: 4
Thank you, that's what I got on my SVR4..I go today to have my 12 wk post treatment blood work done. Wish me luck, I'm nervous!!!

Offline concerned father

  • Member
  • Posts: 79
Best of luck.  I know how you are feeling, my daughter just had her blood drawn after her first 4 weeks of treatment.

Offline KimInTheForest

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  • Believe in yourself
Thank you, that's what I got on my SVR4..I go today to have my 12 wk post treatment blood work done. Wish me luck, I'm nervous!!!

Good luck on today's labs, baffled! I'm sure you'll do great!! :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
I have seen that SVR 4 correlates about 98.5% with SVR 12 so odds are definately in your favor you are in the home stretch!

Good luck
Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline sabre

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  • Posts: 77
Hello all,

1. 12 week post EOT VL status - Undetected
2. Treatment duration - 12 weeks
3. tx naive or experienced - Treatment naive
4. Genotype (1a or 1b) - 1 (just plain old 1)
5. F1-F4 fibrosis status (03/2015) - F2
6. Initial VL (03/2015) - 190,000

Feels incredible.

Wishing the best for all of those who are in treatment or on the wait list, and for those who've relapsed, I hope the new meds in the pipeline are your ticket to SVR.

Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Rosie13

  • Member
  • Posts: 297
So incredible Sabre!! You are on your way! I feel like @ 63 my world is getting so full of possibilities that I had for so long given up on. Just yesterday ( day 26) I trapped a possum who had moved into the garage. I was hiking into the woods to place him in a pristine location for the rest of his life (hopefully) ;). I never would have done that before. Harvoni high or Harvoni just do it! The UPS driver just deliverd bottle #2 . Labs tomorrow...not even worried!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline Redbird29

  • Member
  • Posts: 73
  • I've seen the needle and the damage done.....
Hello all,

1. 12 week post EOT VL status - Undetected
2. Treatment duration - 12 weeks
3. tx naive or experienced - Treatment naive
4. Genotype (1a or 1b) - 1 (just plain old 1)
5. F1-F4 fibrosis status (03/2015) - F2
6. Initial VL (03/2015) - 190,000

Feels incredible.

Wishing the best for all of those who are in treatment or on the wait list, and for those who've relapsed, I hope the new meds in the pipeline are your ticket to SVR.

YAAAAHHHOOEEEYYYYY FOR YOU SABRE!!!!

What wonderful news to hear!!! I hope you enjoy your "new" lease on life and wish you all the very best!!!!
Infected - late 70's /early 80's
GT - 1a

Fibrosure 1/2015 - F1-2
TX Naive - Harvoni 8 wks

SOT 6/25/15  VL - 468,000        AST-44  ALT-56       
EOT  8/19/15  VL-  Not Detected AST-21  ALT-30
1 YEAR POST TX - UNDETECTED AST 20 ALT 22
2 YEAR POST TX - UNDETECTED AST 15 ALT 18

Offline gnatcatcher

  • Member
  • Posts: 1,372
Wishing the best for all of those who are in treatment or on the wait list, and for those who've relapsed, I hope the new meds in the pipeline are your ticket to SVR.
Congratulations, Sabre, and thanks for such a beautifully expressed wish.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline sabre

  • Member
  • Posts: 77
Thanks all!
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Cute

  • Member
  • Posts: 34
Hi all,

As you know, I managed to cure mother from Hepatitis C (according to the results she achieved SVR10 - undetected, next step is SVR24).
But something wrong happens with her. Her liver is worst condition now. She has ascites and fever. Moreover, she had the surgery. Her uterus was removed.
Seems her F3 fibrosis developed to F4 stage. It is very sad to me. All of them happened after successful treatment with Harvoni. I was happy that we killed virus and finally her liver would start its healing process. But now we have totally different picture.

I respect the opinion of the community. Is it possible that her liver will start healing process? How long does it take time? Is anybody here who has already been observing the healing of his/her liver?
All your recommendations are brilliant.
I am so hopeful that her liver will regenerate itself, even there are not so many chances   :(

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
If she has just gone from F3 to F4 she still should be ok I have been F4 for almost 8 years now.

However a fever is a problem and she should see her doctor many things cause fever often infection but cirrhosis does not cause fever.

It is said about 50% of patients with cirrhosis may have imrovemebt with the co diction of their liver but with cure of hep c her liver should not get any worse from this point forwards however we with cirrhosis are at increased risk of liver cancer although that risk is also reduced with cure.

If the ascities is significant the fever could be caused by an infection in the fluid in her abdomin which is very serious. But in any event she should be seen by her doctor soon to find out the reason for her fever.

She can have a long and full live with early cirrhosis as long as she takes care of her liver and flows her doctors recommendations

Good luck to you both
Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Momof3

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  • Posts: 55
Just received my 24 weeks SVR test.... Not detected!! Cured cured cured!!! I feel amazing, it doesn't even seem real! After having this my entire life  it is strange to say I am free from hep c! The best thing is I don't have to worry am I going to be around for my kids, I can now kiss their owes without panic! I thank everyone for the support!!
Hep c GT 1a from transfusion at birth 1986
Treatment naive
Stage f0-f1 fibroscan score 2.5kpa
Harvoni started 02/11/2015 8 weeks
Baseline VL 689,594 ALT 35 AST 25
2 weeks ALT 13 AST 16
4 weeks VL <15 detected ALT 12 AST 15
 UNDETECTED  at EOT April 7
4 weeks post Harvoni UNDETECTED ALT 10 AST 14
12 weeks post Harvoni UNDETECTED ALT 8 AST 15
24 weeks post Harvoni UNDETECTED ALT 13 AST 18

CURED!!!!

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
It's so inspiring to hear all those cured from this disease!  Congratulations and thank you for sharing with us and holding the space for us to follow!  Bree
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Redbird29

  • Member
  • Posts: 73
  • I've seen the needle and the damage done.....
Congrats to you Momo and wishing you all the very best in your future life!!
Infected - late 70's /early 80's
GT - 1a

Fibrosure 1/2015 - F1-2
TX Naive - Harvoni 8 wks

SOT 6/25/15  VL - 468,000        AST-44  ALT-56       
EOT  8/19/15  VL-  Not Detected AST-21  ALT-30
1 YEAR POST TX - UNDETECTED AST 20 ALT 22
2 YEAR POST TX - UNDETECTED AST 15 ALT 18

Offline pl1952

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  • Posts: 24
1. 12 weeks Undetected SVR
2. Treatment duration: 12 weeks
3. tx naive
4. Genotype 1b
5. F1
6. Initial VL 625,000
GT 1b
Treatment naive
2/2014:  Fibroscan 4.5
12/2014:  VL:  650,000
Started Harvoni 3/6/15
EOT: 5-28-15
9-2015:  SVR 12

Offline Rosie13

  • Member
  • Posts: 297
Momof3, you are an inspiration to all!So happy for you!Thanks so much for posting your super results..
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline mario555

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  • Posts: 226
BIXTER.  I just wanted to add my thanks also for your outstanding work! I'm an accountant and I can appreciate the time it takes to tabulate through all the infos. You produce results that help large number of people in their quest for a cure!
I'm always amazed when thinking about the easy ride we have with Harvoni compared to the previous treatments available. Interferon makes me think of our great old days medicine like Leaches and Blood letting!!!
Although I suffered during my 24 weeks treatment, my sides following the end of treatment are slowly abating.  It will be 24 weeks post in 3 weeks and I'll make sure to post my results as soon as I get them.  Don't hold your breath! I live in Eastern Canada and I think they carry liver test results by mules! It takes upward of 8 weeks to get results here and even if I'd be willing to pay let say $10,000, there is nowhere to buy tests here! I am allowed to buy things that pollute as much as I want but I can't buy health services!
Anyway, please continue and yes, I'm curious to know what happened with Charly8. Maybe Lynn K could send a friendly personal message to let him know we all miss him!  Good luck to everyone!
60 years old. Likely infected 1975. Geno 1a
F4  8 millions VL,  AST 140  ALT 140
Generally in good health except problems are creeping up rapidly!
2 failed attempts Inf 2000 and Inf-riba 2010
Harvoni 24 weeks
Start 11/13/2014   EOT 4/27/2015
VL2 - UND
VL4 - UND (may 25)
VL12 - UND
VK24 -  UND
Hopefully cured forever!

Offline sabre

  • Member
  • Posts: 77
Congrats, Momof3! You've been given a new lease. Enjoy your HCV-free life!
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Bixter

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  • Posts: 18
Hello Mario, thank you so much for your kind words. And believe me, I know what you mean by not being able to buy health service, it can be very frustrating. But 8 weeks is an incredible long time to wait. If you have to wait 8 weeks this time too you will have the results at Christmas Eve. Best Christmas gift ever!

Offline mario555

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  • Posts: 226
Hi Bixter. This is exactly what I am counting on, a Christmas gift! I also kept my first bottle to frame it IF I'm still und. We might bitch and holler about sides but, it seems to do the job! Harvoni is our key to a healthier life!
60 years old. Likely infected 1975. Geno 1a
F4  8 millions VL,  AST 140  ALT 140
Generally in good health except problems are creeping up rapidly!
2 failed attempts Inf 2000 and Inf-riba 2010
Harvoni 24 weeks
Start 11/13/2014   EOT 4/27/2015
VL2 - UND
VL4 - UND (may 25)
VL12 - UND
VK24 -  UND
Hopefully cured forever!

Offline juan81

  • Member
  • Posts: 7
Hello Everyone. I just wanted to report my status. I just tested, and I am Negative. It is about 1 year since the beginning of my treatment, in reality SVR 40.

I give all the glory to my Lord, and savior Jesus Christ. Through him, nothing is impossible.

I will continually pray for everyone.
Have a great afternoon and God Bless!



HCV+ 2010 - Born 1981 ~ Geno 1a
Tx Harvoni - 8 weeks ~ 11/1/2014
Treatment naïve
Pre Tx : ALT & AST slightly elevated ~ VL : 47,000 10/21/2014
3 Wk on Harvoni: ALT & AST - Normal ~ VL : Undetected
SVR12: ALT & AST - Normal ~ VL : Undetected ~ 3/19/2015
SVR40: ALT & AST - Normal ~ VL: Undetected ~ 10/03/2015

Offline Rosie13

  • Member
  • Posts: 297
Juan!!!!! Great news & an 8 weeker to boot! You give me renewed hope that 8 weeks will be enough. Thanks for letting us know...& the prayers !
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline juan81

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  • Posts: 7
You are welcome Rosie! 8 weeks is enough... I didn't do anything special. I drank lots of water. And took my pill everyday at the same time...  and thank you!

Offline concerned father

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  • Posts: 79
Great news, after four weeks on Harvoni, my daughter is undetected.  I realize that she still has a way to go for SVR 12 but it's a great start.  For 20 years I've been praying for a miracle cure and I think my prayers have been answered.

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Great news, after four weeks on Harvoni, my daughter is undetected.  I realize that she still has a way to go for SVR 12 but it's a great start.  For 20 years I've been praying for a miracle cure and I think my prayers have been answered.

Phenomenal news! Congratulations to both of you!!! :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline byebyeC

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  • Posts: 286
Congratulations All!!!

And Amen Juan!

So GREAT  Concerned Father!

These are WONDERFUL  stories of hope, courage and delivery!!! <3 <3 <3
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Rosie13

  • Member
  • Posts: 297
Whoo hoooo Concerned DAD! Your daughter is free!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline Cute

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  • Posts: 34
MY CONGRATULATIONS    CONCERNED FATHER!!!

GREAT NEWS  :) :)

Offline Mugwump

  • Member
  • Posts: 778
  • My number of posts means nothing, piscor ergo sum!
Great news, after four weeks on Harvoni, my daughter is undetected.  I realize that she still has a way to go for SVR 12 but it's a great start.  For 20 years I've been praying for a miracle cure and I think my prayers have been answered.
The first time you hear the words virus undetected the joy of knowing that you have the best chance possible to forget about HCV and how it effects you in everyday life is wonderful!

HCV infection becomes a burden no one should shoulder.

I am so happy that your daughter will have a life without HCV, it is a miracle few thought could happen and your faith in her helped greatly, of this I am certain.

All the best to you and your daughter.

Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline lakelady

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  • Posts: 3
genotype 1a
fibroscan 1
Treatment Naive
vl 1.5 mil
8 week Harvoni
4 wk in tx - undetected
EOT - undetected
4 wk SVR - undetected - Feeling Hopeful
« Last Edit: October 15, 2015, 09:15:27 am by lakelady »

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
genotype 1a
fibroscan 1
Treatment Naive
vl 1.5 mil
8 week Harvoni
4 wk in tx - undetected
EOT - undetected
4 wk SVR - undetected - Feeling Hopeful

Congrats on your SVR4 Lakelady! And welcome to the forums. :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Mike

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  • Posts: 999
Congrats Lakelady!

Looks like another dragon is heading to the bone yard!

Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline Rosie13

  • Member
  • Posts: 297
Lakelady! You are rockin' the numbers  & so happy for you! Hopeful is right & by new years eve you will  turning the page.2016  should be an epic year for most of us!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline grodeestok

  • Member
  • Posts: 35
Hey all, posted all my details when this thread first started. Just got my 24 weeks /6 months post tx results. Still undetected!

Offline Rosie13

  • Member
  • Posts: 297
Grodeestok,it doesn't  get an better than that! Congrats on your milestone!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Hey all, posted all my details when this thread first started. Just got my 24 weeks /6 months post tx results. Still undetected!

Way to go, grodeestok!! Congrats on your SVR24!

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline grodeestok

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  • Posts: 35
Thanks friends. Best of luck to everyone! It will happen!

Offline grodeestok

  • Member
  • Posts: 35
Tiger you still on here? How are your numbers?

Offline lakelady

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  • Posts: 3
Thanks for the nice replies, new to posting but during treatment I have been a stalker. Hopefully I may be one of those that helps up the percentage of 8 weekers that make it.

Offline Rosie13

  • Member
  • Posts: 297
Lakelady, I am an 8wker too & do hope that we up those #'s. supposed to hear from my Dr. today about appeal for 1 more month. I am not having a hard time so she wants to push due to my fibroscan. She said the viral load pretreatment should not determine the lengh of tx. Have a great day today! 
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline waitingforrain

  • Member
  • Posts: 10
SVR 12 :)


12 week Harvoni
1a
Mild to No Fibrosis
Treatment experienced x2

Thanks to everyone here for sharing your stories.  It helped to get me through it all. 

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Well a yahoo and a yipeee are in order for waitingforrain and grodeestok!!!
Wonderful news.  I await my 4 week eot and that gives me the heeby Jeebies.  Keep  posting you two.  Don't leave all us waiters in the lurch.

peace
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline grodeestok

  • Member
  • Posts: 35
Thanks beto! I was undetected after 4 weeks in tx and I'm sure you will be too. My hats off to the Warriors who braved the earlier treatments. They are some serious fighters.

Offline Bituman

  • Member
  • Posts: 157
Well by all indications, I think the news is good.  After 12 weeks Harvoni and 24 weeks waiting for it, I did my last lab visit yesterday morning and the results just posted:  HCV RNA UNDETECTED.  My signature is now updated and complete.  By happenstance I visit my IM doc on Tuesday for annual physical.  I'm hoping the term "cured" comes up in our conversation. 

I have been extremely lucky through treatment.  I've had absolutely zero side effects.  I was able to handle a rough patch at work and train for and race several bike events during and after treatment. Maybe things will change tomorrow, but for now life is good and I hope for the same for all of you. 

Bob (86)
Age = 59, male, infected likely 1975
DX 07/07 GT 1a
Biopsy 2007:  GR 1, stage 0, HAI = 2/18
Since 2007:  1.48 MM < VL < 11 MM, avg = 5.64 MM
IL28B=CT
1/26/15, AST=43, ALT=55, VL=3.59 MM
2/5 Start Harvoni 12 weeks; Treat naive
2/20 AST=29, ALT=24, VL=59
3/6 AST=29, ALT=25, VL<15
3/19 AST=24, ALT=22, VL=undet
4/3 AST=29, ALT=25, VL=undet
4/30 EOT, AST=22, ALT=20, VL=undet
5/29 EOT+4, AST=20, ALT=19, VL=undet SVR
7/24 EOT+12, AST=23, ALT=18, VL=undet SVR
10/16 EOT+24, AST=22, ALT=17, VL=undet SVR

Offline GLCII

  • Member
  • Posts: 127
Congratulations an that Great News Bituman.
Pre Tx (VL 12043488) ALT 52/ AST 39
Harvoni Start Date 03/12
2 Week in Tx Results HCV RNA Detected, less than 15 IU/mL. ALT 19 / AST 19
4 Weeks in Tx Results HCV RNA Not detected. ALT 21 / AST 18
12 Week in Tx Results HCV RNA Not detected. ALT 17 / AST 19
--------------------------------------------------------------
Post 12 Week EOT Tx ALT 19/ AST 19 (Undetected)
Post 24 Week EOT Tx ALT 19/ AST 15 (Undetected)

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Congrats Bob!!! thank you for the post...inspiring.  Good luck to all no matter where you are on the trail to SVR
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Rosie13

  • Member
  • Posts: 297
Way to go, Bob! You are my Saturday inspiration!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline waitingforrain

  • Member
  • Posts: 10
Thanks, Beto.  I'll be around.  Wishing the best for you and everyone!

Offline Anita13

  • Member
  • Posts: 14
Husband Roger 4 weeks EOT UD. Geno 1A treated twice before. Once Riba Interferon, second Incivek Riba Interferon.

Offline scott

  • Member
  • Posts: 23
Hi all, I haven't posted or even been here in quite a while but, I am now 12 weeks EOT and just got the result ----  Undetectable YAY!

I started with Harvoni and one month in I was undetectable hence fast responder. But my insurance co. was threatening to allow me only three months. so My good doctor got me going on Ribavarin. INS. co. finally covered me with insistence from my nurse and a lot of hassle for the second three months so in total I received 6 months of Harvoni and 5 months combined treatment with Ribavarin.

I am very pleased with this however I am guessing based oninformation gathered that the definitive test will be three months from now!
 Cheers all and good luck,
   Scott
First infected with HCV 197?
Identified as genotype 1a /cirossis
first treated 1999 NR
2009 NR
2012 pegatron / boceprivir 5 months NR
2014 pegatron /sovaldi 3 months non sustaind virologic response
2015 Harvoni/Ribavarin EOT 12 weeks SVR
2016 Harvoni/Ribavarin EOT 24 weeks SVR - undetectable, finally! YAY!!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Way o go Scott!! Nice!  I was cut to 12 weeks so, you are a lucky man.  Good luck to you my friend.  Happy Hep free life.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline byebyeC

  • Member
  • Posts: 286
Congratulations to all on your SVR!

Let's keep up the good thoughts and prayers for those still going through :)
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Morphin

  • Member
  • Posts: 10
  • Just another survivor
Jumping the gun a bit, went in for my lab work this am, but do have some preliminary results:

1. 4wk - 12 wk EOT VL status -  7 1/2 weeks Still waiting on results
The early results, and why I'm so HOPEFUL is ALT is 30 and AST is 41. Still below the highs before treatment and within normal range.
2. Treatment duration - 8 weeks
3. tx naive or experienced - tx naive
4. Genotype (1a or 1b) - 1a
5. F1-F4 fibrosis status (date) - Possible F1 based on lab work, but never diagnosed/verified by scan
6. Initial VL (date) - 2362235 (4/13/2015)

Will be able to confirm status (undetectable?  ;D) in a few more days - maybe tomorrow, probably next Monday. My intuition is telling me Hep C is eradicated because every day just feels better and better.

For those still waiting, going through, or thinking about treatment - hang in there and keep fighting - the light is coming and it's SO GOOD!

Peace,
Morphin

P.S. Next item on the action list is to fight/advocate for those unable to obtain treatment due to denials/cost.
Age 48
Infected 2001
GT 1a
VL 2.36m 
Tx naive
Started Harvoni 7/7/2015 (8 wks)
W4 - Undetected
W4 AST 33 (66 before TX)
W4 ALT 26 (41 before TX)

Offline Camper

  • Member
  • Posts: 14
   My doctor called me today it's official I am undetected 13 weeks SVR. My viral count in the beginning was 1.5 million and geno type 1A. I had to ask my doctor I did not know. I can't help but think of the ones who still have the virus who failed the treatment and how they must feel. But I strongly feel there will be a cure for everyone soon, the light is at the end of the tunnel. No more medicine no more blood tests its all slowly sinking in to my thinking that I am cured. Hurray!

Offline Rosie13

  • Member
  • Posts: 297
So happy for you camper & morphin!!!! Such great people free to go ahead & dream BIG! Good luck ...we are right behind you looking forward to our day in the sun
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline Lisa Lisa

  • Member
  • Posts: 3
1. 12 wk-<15
2. tx duration-8 weeks started harvoni 3/31/15
3. tx naive
4. Genotype 1b
5. F1-F4 fibrosis status-none or mild
6. Initial VL 294,000 2/2014

will test again mid November to see if undetected.

« Last Edit: October 25, 2015, 09:27:23 pm by Lisa Lisa »

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Hi Lisa

Was that test 12 weeks after your treatment ended?

And the mid November will that test be 24 weeks after your treatment ended?

Good luck to you

Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Lisa Lisa

  • Member
  • Posts: 3
Yes after tx, 12 weeks.  Disappointed it didn't show undetected.  Mid November will be 24 weeks after tx ended.  My ALT and AST are in the 20s and have been since 4 weeks (mid-tx).  Hoping undetected in November.  Thank you.

Offline concerned father

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  • Posts: 79
After 8 weeks of treatment, my daughter is taking her last pill this morning .  I hope her undetected status will stay.

Offline gnatcatcher

  • Member
  • Posts: 1,372
Yes after tx, 12 weeks.  Disappointed it didn't show undetected.  Mid November will be 24 weeks after tx ended.  My ALT and AST are in the 20s and have been since 4 weeks (mid-tx).  Hoping undetected in November.  Thank you.

Lisa Lisa, things are still looking very good for you. Moderator Lucinda Porter, R.N. wrote a helpful article:
http://www.hepmag.com/articles/hepatitis_c_questions_2502_27873.shtml
The relevant portions:
If you are concerned that you may have some residual HCV swimming around in your body, that will someday become a full-blown infection, rest assured, as this is quite unlikely. Hep C replicates a trillion times a day, so “not detected” might as well be zero. It is extremely unlikely that a small amount of HCV will remain alive in your body without having replicated to much higher amounts. In fact, viral load tends to replicate at much higher numbers when treatment fails.
. . .
I just finished HCV treatment, but my viral load was detectable at week 8 and 12.  Does this mean my chances of being cured are low?

No. In the old days, back when treatment was long and used interferon, there were clear milestones that helped us know what our chances were of permanently clearing hepatitis C. Now with new direct-acting antivirals (DAAs), things have changed. Research by the NIH Clinical Center showed that low levels of HCV RNA at the end of treatment are not predictive of treatment response among patients with hepatitis C virus treated with interferon-free regimens. (Clinical Infectious Diseases, March 2, 2015) Harvoni was used in this study, but the trend is likely to apply to all treatments using HCV DAAs.


Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Lisa Lisa

  • Member
  • Posts: 3
Thank you for the article.  I will post my November results.   

Offline Katie

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We are all keeping our fingers crossed for you but being a strong supporter without replication at post 12 weeks, I think you have knocked the virus out.  Positive thoughts sent your way!

Katie
1 year post treatment blood work done and I am FREE!
GT 1a (4/1/2016)
Dx 2005
VL 2.6 million (fluctuated from 2-16 million during the 9 years)
Started Tx 12/4/2014 for 12 weeks
4 week blood work  Detected 59 IU/mL
EOT Detected <12 IU/mL
7.5 weeks post  Undetected
16 week post Undetected
24 WEEK POST UNDETECTED (I made it)
Waiting to feel good but feeling blessed!
12 month post treatment.  All blood work absolutely perfect! VL, as expected UNDETECTED!

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
When I relapsed last year after treating with Sovaldi and Olysio for 12 weeks when I was tested 12 weeks after I finished my viral load was 2.4 million even though I was not detected at week 4 and at EOT 12 weeks.

Hep c doesn't sneek back it comes roaring back if it is coming back.

Fingers crossed for your 24 week test
Lynn
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Morphin

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  • Just another survivor
Jumping the gun a bit, went in for my lab work this am, but do have some preliminary results:

1. 4wk - 12 wk EOT VL status -  7 1/2 weeks Still waiting on results
The early results, and why I'm so HOPEFUL is ALT is 30 and AST is 41. Still below the highs before treatment and within normal range.

UGH - after a LONG 5 days, my 8 week test finally came in.

UNDETECTED



Going to go cry tears of joy now.  ;D
Age 48
Infected 2001
GT 1a
VL 2.36m 
Tx naive
Started Harvoni 7/7/2015 (8 wks)
W4 - Undetected
W4 AST 33 (66 before TX)
W4 ALT 26 (41 before TX)

Offline slats1056

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  • SVR to all and to all a good life!
  Morphin,  Excellent News ;D ;D. Classic happy dance You posted there! Charlie & Snoopy are iconic. The waiting is the hardest part. Good luck & good health to You!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
Morphin...Sweet!
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Great news Morphin

May I join your happy dance? I just got my 24 week post results today.

SVR 24! No more hep c for me!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline beto

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  • "no risk it, no biscuit"
Lynn...I am absolutely thrilled for you...your 24...wow...touchet
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Patience

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  • Posts: 40
Lynn,

Fantastic! Such wonderful news! You've been so helpful and supportive on this forum. Thank you!
GT 1b
Dx2000
Tx2005 peg/rib. responder but had to stop at 20 weeks due to eye and thyroid problems. Relapse 3 months later
2013 fibrosis F2-1
TX 6/7/15 Harvoni 12 weeks VL 815,000, log 5.91,     ALT 47, AST 80
@3 weeks: VL detected <15, log <1.18
@ 9 weeks VL Undetected
EOT 8/29/15 no labs done
12/3/15  14 week post EOT: UNDETECTED!!
 ALT 11 AST 21
2/19/16  24 week post: UNDETECTED

Offline Philadelphia

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  • It only looks like I know what I'm doing
Wonderful news Lynn. So very happy for you. :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline KimInTheForest

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Got my latest results: I reached SVR12. No virus remaining in this ole bod after 40+ years of co-existing with the dang thing!!!  :D

For the data compilation on this thread, I am Genotype 3a, and I got my 12 weeks of Harvoni+ribavirin through a clinical trial:

1. 12 week EOT: undetected (SVR12)
2. Treatment duration: 12 weeks (Harvoni+ribavirin), starting May 5, 2015
3. tx naive or experienced: tx naive
4. Genotype (1a or 1b): Genotype 3a
5. F1-F4 fibrosis status: F2 (April 2015)
6. Initial VL: 4 million (May 5, 2015)

And huge congrats to Lynn K & Morphin on your recent SVR-24's !

best to all,
kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline gnatcatcher

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Kim, I'm glad there's a happy ending, especially after all that you have endured.
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline concerned father

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Congrats to Lynn K, Kim & Morphin  :)
« Last Edit: October 28, 2015, 02:31:28 pm by concerned father »

Offline dearprudence

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Got my latest results: I reached SVR12. No virus remaining in this ole bod after 40+ years of co-existing with the dang thing!!!  :D

For the data compilation on this thread, I am Genotype 3a, and I got my 12 weeks of Harvoni+ribavirin through a clinical trial:

1. 12 week EOT: undetected (SVR12)
2. Treatment duration: 12 weeks (Harvoni+ribavirin), starting May 5, 2015
3. tx naive or experienced: tx naive
4. Genotype (1a or 1b): Genotype 3a
5. F1-F4 fibrosis status: F2 (April 2015)
6. Initial VL: 4 million (May 5, 2015)

And huge congrats to Lynn K & Morphin on your recent SVR-24's !

best to all,
kim

Hi Kim,
A HUGE WOO HOO for reaching 12week SVR! SVR 24 weeks hooray for Lynn and Morphin!
I have been feeling great and taking care of things that got backed up during treatment.
Found out Tuesday that my anemia is gone! 12 week blood will be done next week and dr. visit with ultrasound on Nov. 9th. I will keep you posted. Even though I'm a VPak & Riba girl, I hope to join you in 12 week undetected status!
All my best, Prudence

Offline dragonslayer

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Congrats Kim!!!   
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline KimInTheForest

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Thank you gnatty, concerned father, prudence, paul & all others on other threads for your good wishes!! It's pretty amazing. How many of us ever thought the cure for Hep C would be developed in our lifetimes? Not me. I'm still getting used to the New Reality of my New Life. :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
congrats kim who lives in a forest and not in Hawaii...you da bomb
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline rt2cup

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  • Posts: 11
Been looking for information on post treatment with Harvoni, 12 weeks.  Unable to find any real studies.  This forum has provided some good information, thanks.
In a week I will do my 12 wk. blood work and on November 11th, I should find out if the virus is cleared.  I will post my results than.

A little background, found out I had non-A non-B Hep back in the early 80's.  Around 2002, I decided to try the (excuse spelling, to lazy to look up correct spelling), Sher-Plough, peg-Interferon and ribivian treatment for 48 weeks.  I cleared the virus but relapsed.  Decided to try Harvoni, finish treatment mid-August.

1b, IL28B, CT genotype

AST and ALT markers normally slightly high, for example in 2002, 42 and 45, this was before first treatment.  AST and ALT markers vary over the years.

VL:  05/22/02    220 IU/ml
VL:  08/26/02    <10             this was the beginning of treatment.
VL:  12/10/02    <10
VL:  04/09/03    22500000
VL:  05/10/04    58900000

AST  161  ALT 269  11/15/2005  continue to be high but decreasing for example, 02/14/2008:  AST 80 and ALT 120
Fast forward to 03/24/2015:  AST 46 and ALT 72
VL:  124610 IU/ml
The fibrosis stage:  could not be calculated for this patient.  Testing revealed an unusually high or low value for one or more of the biochemical analytes.

Anyway over the years I have had a few needle biopsy and now a few ultrasounds, results increasing fibrosis.  Latest ultrasound:  "Slightly coarsened hepatic echotexture compatible with cirrhosis is again noted.  No focal hepatic mass is demonstrated. Hepatic length 15cm."

Found my VL results for 6/24/2015 while on Harvoni:   Undetected  test limit <15 IU/mL

Let you know results when I get them.
« Last Edit: October 29, 2015, 05:07:22 pm by rt2cup »

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Hi rt2cup

Here is a link to the ION-2 clinical trial results which was 12 or 24 weeks for treatment experienced with about 20 % who have cirrhosis.

http://depts.washington.edu/hepstudy/presentations/uploads/121/ion2ledipasvirsofosbuvir.pdf

Good luck with your post treatment results

Lynn

And congrats to you too Kim!
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline 2rivers

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  • Posts: 26
I have just receive my 12 week EOT results and am happy to report no detected HCV. After 45 years of living with the virus (1B) I did 8 weeks of Harvoni. I was undetected at 4 and 8 weeks (EOT), and now at 20 weeks. All my liver enzymes are well within normal ranges as well. I hope this information will provide hope for those currently undergoing treatment.

Offline slats1056

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  • SVR to all and to all a good life!
 Man, out  of pocket for a day and look at all the good news flowing in!

  Lynn, Happy, Happy, Happy for You ;) You are one of the most derserving of SVR after all You have been through! Excellent and CONGRATULATION ;D ;D ;D Happy Dance until You drop!!!!

  Kim, Most excellent for You also! ;D Hope all is well in the forest once again! :) Be careful not to step on the little critters when Your dancing Your Happy Dance! 8) Tip Toe Through The Tulips Anyone?? ;)

   2rivers , Yet another big win chalked up in the battle against evil forces! :) I feel the Earth shaking with all the Happy Dances going on around the World. Glad to hear all of this good news!!!

 Waiting for the day that all posts here will be good news and SVR! Let's do it Guys!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
   Kim, Most excellent for You also! ;D Hope all is well in the forest once again! :) Be careful not to step on the little critters when Your dancing Your Happy Dance! 8) Tip Toe Through The Tulips Anyone?? ;)

Haha! Will do Tommy. The little critters around here are mainly banana slugs and black bears. But I will watch out for both! ;)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

 


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