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Author Topic: 12 wks with or without ribavirin?  (Read 4930 times)

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Offline ricpark

  • Member
  • Posts: 87
12 wks with or without ribavirin?
« on: May 02, 2015, 10:21:57 pm »
I have in my hands Harvoni and Ribavirin and to start in 2 days (5/4/15). According to Gilead being treatment naive, genotype 1a, stage 3, viral count 17.5 mil, I would only need Harvoni for 12 wks. They stated over the phone to me that they found no benifit from Ribavirin. The 6 mil break point is for 8wks. There is a study from France I think that says Ribavirin helps. Do I piss off my doctor and refuse the Ribavirin? I'm still having side effects from my cancer treatment from a year ago and looking to avoid new side effects if possible (getting cured is my first choice).
Chronic 50 years
Geo 1A Stage 3
VL 17.5 mill
non-Hopkins lymphoma cancer
after 4 weeks
AST 87 now 29
ALT 128 now 27
VL now undetected
after 12 wks
VL  undetected

Offline atomic dog

  • Member
  • Posts: 160
Re: 12 wks with or without ribavirin?
« Reply #1 on: May 02, 2015, 11:17:15 pm »
I would at least ask for clarification about why the dr prescribed the Riba.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,542
  • Get tested, get treated, get cured, fight Hep c!
Re: 12 wks with or without ribavirin?
« Reply #2 on: May 03, 2015, 12:18:25 am »
Per the American Association for the Study of Liver Diseases (AASLD) Recommendations for Testing, Managing, and Treating Hepatitis C INITIAL TREATMENT OF HCV INFECTION


Three options with similar efficacy in general are recommended for treatment-naive patients with HCV genotype 1a infection (listed in alphabetic order; see text).

Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg) for 12 weeks* is recommended for treatment-naive patients with HCV genotype 1a infection.
*See text for further detail on length of treatment

Rating: Class I, Level A

Daily fixed-dose combination of paritaprevir (150 mg)/ritonavir (100 mg)/ombitasvir (25 mg) plus twice-daily dosed dasabuvir (250 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis) is recommended for treatment-naive patients with HCV genotype 1a infection.

Rating: Class I, Level A

Daily sofosbuvir (400 mg) plus simeprevir (150 mg) with or without weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis) is recommended for treatment-naive patients with HCV genotype 1a infection.

Rating: Class IIa, Level B

SVR for Genotype 1a treatment naive without cirrhosis in the ION 3 clinical trial 96% (165/172) after 12 weeks of Harvoni

I would discuss with your doctor just what you said about still having side effects from cancer tx and wanting to avoid side effects if possible. You do have F3 which is almost F4 which maybe why he wants you to be treated as though you have cirrhosis which then the recommendation is 12 weeks Harvoni and Riba or 24 weeks Harvoni without Riba so that is something you may want to think about as well you really do need to cure your Hep c on this shot

Good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!


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