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Author Topic: My husband & I are different geno types (1a & 3)  (Read 5031 times)

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Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
My husband & I are different geno types (1a & 3)
« on: May 04, 2015, 10:32:30 am »
So my husband finally got his test results back and he has a different genotype than I do.  :(  (I am 1a and he is 3)
The treatment for genotype type 3 is Sovaldi/Riba-He does not have cirrhosis and in fact his liver is in fantastic shape according to our doctor.  This is all so bizarre because he has the most aggressive form and yet is liver is fine and I have the "easiest to cure" and I have pretty bad cirrhosis.  Go figure right?
His doctor recommended that he wait for a new drug that is buzzing all over Europe that supposedly will clear FDA in about July.  This new drug promises to be the next Harvoni for genotype 3 so he is going to wait.  I have the name written down somewhere and will post it when I find it
  it is called Daclatasvir by Brystol Myers Sqibb.  (I did some research on it-this is what I found)

http://news.bms.com/press-release/bristol-myers-squibb-announces-acceptance-new-drug-application-investigational-daclata

Also from this website: http://www.hepmag.com/articles/daclatasvir_NDA_2501_26948.shtml

Something I just thought of is cross contamination.  Especially for me since I am already on my 3rd week of Harvoni.  Obviously I will take every precaution and then some because I cannot afford to not clear this virus.

This is all overwhelming
 
Has anybody else experienced something like this?
 
« Last Edit: May 04, 2015, 03:01:59 pm by Debula »
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline lporterrn

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  • Member
  • Posts: 1,982
  • LucindaPorterRN
    • LucindaPorterRN
Re: My husband & I are different geno types (1a & 3)
« Reply #1 on: May 04, 2015, 08:45:45 pm »
Hi,
Although I haven't experienced this, I have seen it. The most likely explanation is that you were each infected separately. As for the progression, it is odd that you are more progressed, esp since men tend to progress faster. Do you drink, smoke, or take meds that might be hard on the liver?

Sounds like your doc is giving you good advice.

I wish you the very best with treatment. Stay close and let us know if you have other questions.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
http://blogs.hepmag.com/lucindakporter/

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: My husband & I are different geno types (1a & 3)
« Reply #2 on: May 05, 2015, 11:19:23 am »
Hi! Yes I figured we were infected separately but were both kind o blown away that he was a genotype 3
We both smoke, actually he smokes 3 times as much as I do.
We both quit drinking over 20 years ago
I do not take any meds other than my Thyroid med
He takes Suboxon
Very weird that I have progressed so much more.  I'm wondering if it has anything to do with genetics, where my heritage might be more prone.  I don't know what to think really.
Thanks to you and an article of yours,  I found this site and Harvoni so hopefully I will beat HepC and try to stop more damage from happening.
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

Offline Mike

  • Global Moderator
  • Member
  • Posts: 993
Re: My husband & I are different geno types (1a & 3)
« Reply #3 on: May 05, 2015, 06:11:41 pm »
Although it is possible for a genotype to "switch" within an individual, it is rare and appears to relate to a "superinfection."

Thus:

HCV genotypes switches can occur

• 6 of 14 hemodialysis patients experienced HCV genotype
change after 13-21 months of follow-up

– Genotype switches “may be due to either genotype-specific intermittent
viremic status or viral interference”

• HCV genotype change observed in 19 of 32 hemophiliacs and
were more common in HIV-positive individuals

– Genotype switches could be false hybridizations during line probe assay
or changes in predominant strains during mixed infection

• HCV genotype change in 4 of 15 IDUs (23.3 per 100 personyears
of observation

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0CB4QFjAA&url=http%3A%2F%2Fwww.cdc.gov%2Fhepatitis%2FResources%2FMtgsConf%2FHCVSymposium2011-PDFs%2F20_Blackard.pdf&ei=uz9JVeCrJ8SZgwTN_oDADg&usg=AFQjCNHid9pdVP4a9-y_rWxsI0owrS2Nmw&bvm=bv.92291466,d.eXY


Best wishes, Mike
Genotype 1a
Treated 2001 with PEG and RIBV
Treated in 2014 SOL+PEG+RIBV
Cured July 2014

Offline Debula

  • Member
  • Posts: 257
  • "Your body hears everything your mind says"
Re: My husband & I are different geno types (1a & 3)
« Reply #4 on: May 06, 2015, 10:05:11 am »
Interesting stuff Mike, thank you
80's DX: NonA,B
Non responder to Interferon
3/6/2015-GT 1a
VL-1920000 IU/mL
FibroSURE: Fibrosis stage F4 (0.79)
                  Necroinflammat activity A3 Severe (0.75)
AST 88,  ALT 120, Platelets 73
4/16/2015-Started Harvoni (24 weeks)
5/13/2015-4 weeks AST 26, ALT 36 
5/22/2015-5 weeks  VL UND
6/17/2015-9 weeks  VL UND AST 28 ALT 40
7/31/2015-15 weeks VL UND AST 27 ALT 39
9/22 Diagnosed with HCC
10/1-EOT
10/29-SVR4
12/23-SVR12
I AM HEPC FREE! :)

 


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