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Author Topic: Elavated Ast & Alt 16 weeks post treatment  (Read 12925 times)

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Offline Mikee

  • Member
  • Posts: 28
Elavated Ast & Alt 16 weeks post treatment
« on: June 10, 2015, 05:01:57 pm »
Hi Everyone, I was still undetected 12 weeks post Harvoni treatment on 12 week eot test my ast was slightly elavated.I had my dr do a CMP last week and my ast was 81 and my alt was 52. I had him do a iron test also because  this was high in the past this was now normal as was everything else. With Hcv my enzymes would be more highly elavated with alt twice what ast is this time ast is higher. What do you think anyone ?

Offline Mikee

  • Member
  • Posts: 28
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #1 on: June 12, 2015, 02:54:42 pm »
I see a Hcv RNA in my future.as

Offline dragonslayer

  • Member
  • Posts: 873
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #2 on: June 12, 2015, 03:01:47 pm »
I see a Hcv RNA in my future.as

Mikee... check out this article:
http://www.journal-of-hepatology.eu/article/S0168-8278(13)60850-8/pdf

You will see that once you are SVR12, there is practically NO chance of relapse... SVR12 correlates with SVR24 to the tune if 99.8% of the time.  Even SVR4 correlates with SVR24 99% of the time.  The odds are minuscule, as you can see, that youll have any issue with viral load in the future, given your SVR12 status of UND.

As for the liver enzymes, any lifestyle reasons they might be elevated?
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Mikee

  • Member
  • Posts: 28
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #3 on: June 12, 2015, 03:52:14 pm »
Haven't had 1 drop of alcohol but have been doing a lot more physically demanding work.My muscles have been s or for 5 weeks. Also my creatinine  is higher than it has been and my gfr is slightly low.

Offline sabre

  • Member
  • Posts: 77
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #4 on: June 12, 2015, 06:20:59 pm »
Out of curiosity, what is your exact creatine level and GFR? Any other kidney-related labs?
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Mikee

  • Member
  • Posts: 28
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #5 on: June 12, 2015, 06:52:54 pm »
Creatinine 1.36 and gfr 54 non african american no other issues.

Offline KimInTheForest

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  • Posts: 1,972
  • Believe in yourself
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #6 on: June 12, 2015, 08:23:08 pm »
Intense physical workout all by itself can raise liver enzymes above normal. I think you will find references to that if you google it.

Here is something on that:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291230/

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline sabre

  • Member
  • Posts: 77
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #7 on: June 13, 2015, 06:02:00 pm »
Mike, your creatinine level is not too bad. Mine is consistently in the 1.6 range.

From experience, I know the GFR can vary. If your levels are below 60 for three months in a row, you may want to ask for a urine test to see if you're spilling any protein in your urine.

How's your blood pressure?
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline Mikee

  • Member
  • Posts: 28
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #8 on: June 13, 2015, 06:49:32 pm »
140 over 80 borderline also sugar was 122. I also ate a Bacon and cheese sandwich beforehand.  Im gonna wait a couple weeks and take a fasting cmp..

Offline sabre

  • Member
  • Posts: 77
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #9 on: June 13, 2015, 11:55:03 pm »
I'm in the 164/90 range but I have kidney issues.  Having said that, Harvoni does raise BP in some of us. I'm hoping that mine drops some after I've finished treatment.

If you ate bacon before that test, yours is probably fine, lol.

Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline lin44

  • Member
  • Posts: 15
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #10 on: June 14, 2015, 07:38:30 am »
Just wondering did. You have normal blood pressure prior to harvoni

Offline Mikee

  • Member
  • Posts: 28
Re: Elavated Ast & Alt 16 weeks post treatment
« Reply #11 on: June 14, 2015, 10:52:35 am »
Yes

 


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