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Author Topic: med interactions  (Read 7811 times)

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Offline nolacs22

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  • Posts: 12
med interactions
« on: June 13, 2015, 02:56:32 pm »
Does anyone out there know if it is ok to take probiotics while taking Harvoni? ;) Also is aspirin safe to take? My doctor said "Do NOT take Tylenol period",it is poisonous to the liver.
« Last Edit: June 14, 2015, 01:57:09 pm by nolacs22 »
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Offline sabre

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Re: med interactions
« Reply #1 on: June 15, 2015, 12:28:56 pm »
Probiotics are not contraindicated with Harvoni. I don't see how they could interact with Harvoni given this 'good bacteria' already exists in a healthy GI system. But, who am I?

You could call the prescribing pharmacy or call Gilead and ask them directly.
Logged
Infected 1980 / Diagnosed 2008
GT 1 / Treatment naive / VL 190,000
Biopsy 2008: stage 0 grade 1
Fibroscan 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria

12 weeks Harvoni began on 03/28/2015
End of treatment: 06/19/2015
Labs on 06/17/2015: Undetected
Labs on 09/21/2015: Undetected (SVR12)

Offline trixiedaisy

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Re: med interactions
« Reply #2 on: June 17, 2015, 08:42:24 pm »
Yes nolacs22 I agree with sabre!  When I first found about my Hep C my pharmacist  (was working with him at the time) told me do not take Tylenol ever again it is poison to your liver ! I also don't think probiotics wouldn't hurt but yes do talk to your gastro dr. or again your pharmacist. I have found over the years pharmacists do know more then doctors as far as meds and side effects!!! I call mine all the time. We have talked for so long now I swear he is going to invite me to the family reunion lol. You are lucky if that's all you take. I don't think you have anything to worry about but call your pharmacist or the pharmacist you got the Harvoni from. It will ease your mind. Good luck hun !   
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Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: med interactions
« Reply #3 on: June 17, 2015, 11:15:33 pm »
Hi nolacs

As far as aspirin it depends how much liver damage you have and if you are in any danger of a GI bleed like I am because I have cirrhosis for 7 years now with portal hypertension.

For a patient with cirrhosis the recommendation is to avoid all NSAIDs Advil, Motrin, Aleve including aspirin because they can be very dangerous to a patient with advanced cirrhosis and result in a serious bleeding episode.

When I was diagnosed with cirrhosis my hepatologist said I need to only take Tylenol because of that danger of upper GI bleeding.

Tylenol is safe for people with liver disease as long as they do not exceed the recommended dosage 2000 mg/day. Less is better and also not every day so basically go easy on the Tylenol and don't take anything else is what I am told.

The problem is that Tylenol is in many combo medicines and without reading ingredients in combo medicines especially cold medicines it can be easy to take more than the recommended daily amount.

But your situation is different from my situation so always best to go with what your doctor recommends.

Here is a link titled "Pain Management in the Cirrhotic Patient: The Clinical Challenge"
Article by Mayo Clinic Proceedings

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861975/

Good luck on treatment
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline trixiedaisy

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  • Posts: 8
Re: med interactions
« Reply #4 on: June 20, 2015, 04:22:55 pm »
Tylenol is safe as long as you take the recommended dosage of 2000 mg. per day?????? Huh that is crazy to say. 2000 mg. would totally kill your liver! You ask any doctor that treats or knows about Hepatitis C and they will tell you DO NOT TAKE TYLENOL if you have Hepatitis C. Amen
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Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: med interactions
« Reply #5 on: June 20, 2015, 05:56:12 pm »
But if you have cirrhosis, Tylenol is safer than the other painkillers and is the painkiller recommended by GPs GIs and hepatologists. Other painkillers such as asprin have anti clotting properties and one of the great risks for cirrhosis is internal bleeding that can't be stopped.

Once you get to the cirrhotic stage, the rules change.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Lynn K

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  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: med interactions
« Reply #6 on: June 20, 2015, 10:53:19 pm »
Well my link was from the U.S. national institute of health and that is the recommendatio  of my hepatologist who is the head if the liver center at a liver transplant hospital in Seattle and that is the maximum safe dosage of course you want to minimize whenever possible. But Advil, Aleve and aspirin are entirely too dangerous for me with ESLD cirrhosis.

Like Philedelphia says the rules change
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!
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