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Author Topic: Reversal of Fibrosis  (Read 6865 times)

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Offline hepclady

  • Member
  • Posts: 7
Reversal of Fibrosis
« on: February 17, 2016, 08:30:45 am »
Hi,  I am new to this list and not sure how to post.  Not sure if this has been covered.  I would love to hear any stories of reversal of advanced fibrosis after taking Harvoni or other drug to heal hepatitis c.  If reversal did occur, how long did it take and did it just happen spontaneously or did you take any herbs or follow any special diet to improve your liver?

Thank you very much for any information.

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Reversal of Fibrosis
« Reply #1 on: February 17, 2016, 05:41:54 pm »
Hi hepclady and welcome to this forum!  You will find a TON of valuable info, plus support, here. I'm getting ready to start Harvoni after fighting a year for it, but have been following this forum for several years.  I'm not sure there's an answer to your question as of yet, as Harvoni was just approved in Oct. 2014, Vierka Pak in Dec. 2014, Daklinza last summer, Zepatier last month and another probably will be in June!  These are all very new drugs and lots of information is rolling in as more and more HCV patients take them. I imagine this issue of fibrosis reversal will be coming up in the data; perhaps the moderators can help with this question.

Each drug has a list of drugs/etc. to avoid, which can be found in their prescribing info. Your doctor will be the best resource; I'm not familiar with herbs, as I never took any for this condition. All the drugs are just so new -- but thankfully they are now here! Lots of hope now, as compared to just 2 years ago.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Reversal of Fibrosis
« Reply #2 on: February 17, 2016, 06:15:54 pm »
 Maybe Beto can chime in about his Fibroscan results.
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Reversal of Fibrosis
« Reply #3 on: February 17, 2016, 07:41:15 pm »
http://forums.hepmag.com/index.php?topic=3467.msg36179#msg36179

Here's someone who's been looking into that very thing.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,543
  • Get tested, get treated, get cured, fight Hep c!
Re: Reversal of Fibrosis
« Reply #4 on: February 18, 2016, 01:59:44 am »
Hi Hepclady

A lot depends on how much liver damage you currently have.

Those with F0 to F2 after SVR will be followed as though they never had hep c while those like myself with more significant liver damage only time will tell.

I was diagnosed with cirrhosis in Jan 2008 I will need to have abdominal ultrasounds and AFP blood tests to monitor for signs of liver cancer likely for the rest of my life even though my hep c is cured as I still have cirrhosis.

Good luck to you
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline BillT

  • Member
  • Posts: 573
Re: Reversal of Fibrosis
« Reply #5 on: February 18, 2016, 11:49:29 am »
Hi Hepclady,
                 I was looking for information on that myself a while back.There are several studies going on about that I ran across.This article is from 2008.I know there was one I read from 2014 on this same study but I can't find it right now.I'm sure there is more but my mind isn't into searching today.There's also one I read that was being done in the Netherlands.I'll look for them and post them later.


http://www.biotechdaily.com/?option=com_article&Itemid=268420000
« Last Edit: February 18, 2016, 11:55:07 am by BillT »
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline FutureThinker

  • Member
  • Posts: 711
  • Onward and upward!
Re: Reversal of Fibrosis
« Reply #6 on: February 18, 2016, 12:00:10 pm »
Else, thank you so very much for posting that link ---- awesome info there!!!!! There is so much great info on this forum, it's hard to find it all, so thank you very much.  I will definitely be returning to that thread during my treatment process. 

Lynn, as always, thank you, too, for your sound info and advice.  FT
Treatment naive
Likely contracted mid-70s
Diagnosed 1a, 2011
F1-2
Harvoni X 12 weeks, completed 5/17/16
Pre-treatment: VL 3 mil, AST 64, ALT 84
4 week labs: VL 30, AST 21, ALT 14
8 week labs: VL UD!!!, AST 22, ALT 16
12 week labs: VL UD, AST 23, ALT 14
2 wk EOT: VL UD
12 wk EOT: VL UD, AST 22, ALT 13 =  SVR 12! Yay! 
Last hep appointment: VL UD, AST 19, ALT 12 = SVR 39! I AM DONE!

 


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