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Author Topic: 1 year after SVR, now sides manifesting [ shorter version]  (Read 12282 times)

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Offline Nobody Special

  • Member
  • Posts: 7
1 year after SVR, now sides manifesting [ shorter version]
« on: June 17, 2015, 01:43:24 pm »
One year after SVR & suddenly am experiencing the following sides

nausea
dizziness
constipation
+ slight occasional shortness of breath

This has been the case for over a month now.

I was on a 5-part combo from Abb-Vie:
ABT-450/r, a protease inhibitor taken with ritonavir; the NS5A inhibitor ABT-267; the non-nucleoside polymerase inhibitor ABT-333; and ribavirin

Also, bloodwork found glucose at 112, and will take follow-up test of determine if diabetes is in the picture.

Apologies for previous post being too dense.

Anyone else in the group having similar post- symptoms, (Abb-Vie or not) ?

Thank you.

Yours, in health,
Nobodhi

Offline Lynn K

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  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #1 on: June 17, 2015, 03:23:55 pm »
Was that a fasting glucose? What is the normal range for your lab? For my lab 100 is max normal for fasting. If you had eaten before the glucose test 112 could be totally normal.

What does your doctor say about your glucose test result?

The rest I have no idea what does your doctor say about your symptoms?

Congrats on your SVR
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Nobody Special

  • Member
  • Posts: 7
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #2 on: June 17, 2015, 03:49:21 pm »


No it wasn’t a fasting glucose -- and may be a false flag

Am too dizzy right now to write anything coherent ... thanks. Lyn

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #3 on: June 17, 2015, 08:20:27 pm »
Not really a false flag my test says in the notes standard for fasting only no standard for non fasting so basically a glucose test result doesn't mean much if it is Non fasting.

If you have concerns about your glucose you should repeat the test when fasting
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline Nobody Special

  • Member
  • Posts: 7
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #4 on: June 17, 2015, 08:32:27 pm »
False flag may have been the wrong phrase, or out of context, apologies ( am dizzy & nauseous ).  It’s the dizziness fatigue & nausea (+ constipation ) that presents itself, & about which I’m perplexed, shall we say -- like, why? what’s going on ?  Has anyone else had similar sides, from a clinical trial (AbbVie or not) ...  if so, what did they find out about it ( diagnosis, prognosis, Rx ) ...

Offline atomic dog

  • Member
  • Posts: 160
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #5 on: June 19, 2015, 12:55:52 am »
I'm unclear why you're calling these symptoms sides. If you are one-year post treatment it seems that these symptoms are indicative of an undiagnosed medical condition.
Infected 1969, dirty needle
Geno 1a
Stage 2 fib, some necrosis
TX naive
1/29/15 ALT61; AST43
2/16/15 Started Harvoni; VL 1.5 m;
2/19/15 ALT40; AST24
2/29/15 ALT29; AST25
3/9/15 ALT28; AST25; 
3/9/15 < 20 IU/mL (3 wks) HCV RNA remains 'detected'
3/24/15 ALT30; AST25;
3/24/15 <20 IU/mL (5 wks) HCV RNA
4/10/15 <20 IU/ml (7 weeks) HCV RNA
4/20/15 ALT36; AST27
4/20/15 UND
5/11/15 UND (EOT); ALT33; AST25
6/11/15 UND; ALT 34; AST 29
8/14/15 UND
11/15/15 SVR, 24-wk EOT

Offline Lynn K

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  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #6 on: June 19, 2015, 01:15:35 am »
Good point sides or side effects are from a medicine

side ef·fect
noun
plural noun: side effects

    a secondary, typically undesirable effect of a drug or medical treatment.
    "many anticancer drugs now in use have toxic side effects"


While symptoms are what are experienced as a result of a medical condition 


symptom
[simp-tuh m]

    Synonyms
    Examples
    Word Origin

noun
1.
any phenomenon or circumstance accompanying something and serving as evidence of it.
2.
a sign or indication of something.
3.
Pathology. a phenomenon that arises from and accompanies a particular disease or disorder and serves as an indication of it.

Since you no longer have any medicines in your system they would be symptoms of some medical condition.
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline elizabethfaraone

  • Member
  • Posts: 56
  • happy and in love with Michael Sofia
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #7 on: June 21, 2015, 08:38:59 pm »
Thank you for posting this.  We are all learning as we take these medicines.  They are new and we won't know all of the adverse post-treatment effects until we gather information from one another.  Please keep us updated on what you find out about why you are experiencing these symptoms.  Can you email me your longer version?

One year after SVR & suddenly am experiencing the following sides

nausea
dizziness
constipation
+ slight occasional shortness of breath

This has been the case for over a month now.

I was on a 5-part combo from Abb-Vie:
ABT-450/r, a protease inhibitor taken with ritonavir; the NS5A inhibitor ABT-267; the non-nucleoside polymerase inhibitor ABT-333; and ribavirin

Also, bloodwork found glucose at 112, and will take follow-up test of determine if diabetes is in the picture.

Apologies for previous post being too dense.

Anyone else in the group having similar post- symptoms, (Abb-Vie or not) ?

Thank you.

Yours, in health,
Nobodhi
Infected in 1987 in China when MD administered acupuncture with reused needle
Diagnosed 2001
Genotype 1a w/ Q80K polymorphism
Attempted treatment with Interferon/Ribavirin 2003 and stopped immediately
2014 fibroscan no fibrosis
2014 abdominal ultrasound normal
Found gastroenterologist to advocate for me upon Harvoni approval by FDA
Began treatment w/ Harvoni December 2014
Undetected at four weeks
Completed 12 week treatment February 2015
Blood tests normal
ElizabethFaraone@yahoo.com

Offline Phil

  • Member
  • Posts: 21
Re: 1 year after SVR, now sides manifesting [ shorter version]
« Reply #8 on: June 28, 2015, 07:13:33 pm »
Dizziness and nausea are two of the more common and nonspecific symptoms in all of  medicine. The possible causes are extensive. What is extremely unlikely is the association of those, as new symptoms, to a course of medications completed a year ago.

One of the most common causes of dizziness, nausea, and constipation as a set of symptoms, is dehydration. That dehydration may not be obvious as to cause, onset, or objective signs. Meaning heart rate, blood pressure, dry mouth, the numerous causes, and so forth. May not be entirely obvious to you, your state of hydration. For example new onset diabetics often think they cannot be dehydrated because they drink A LOT of fluids. But they are. Often profoundly. They lose more fluid than they take in. Can occur very gradually. Of course dehydration is only one of many causes of these symptoms.

Point is there are a whole host of causes of dizziness, nausea, and constipation, all astromonically more likely than medications completed a year ago, or even the disease hepatitis C itself. Evaluation and treatment by a reliable physician is of course the remedy.

Phil
« Last Edit: June 28, 2015, 07:22:06 pm by Phil »

 


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