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Author Topic: Viekira Pak for those who failed Harvoni  (Read 6702 times)

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Offline sickpuppy

  • Member
  • Posts: 51
Viekira Pak for those who failed Harvoni
« on: July 28, 2015, 04:46:51 pm »
What are the views on this? Is a Viekira Pak + Ribavirin for 24 weeks realistically recommended for retreatment for those who tried Harvoni and failed?

What do you think?
GT1a - TX-naive

Baseline:

16.2 kPa
ALT: 61 iu/L
ALP: 74 iu/L
Albumin: 38g/L
Bilirubin: 27 umol/L
Platelets: 80
VL: 792,000
History of 4 violent varices bleeding episodes and splenomegaly present.

21/07/15 - TX start - Harvoni + Ribavirin 12 weeks.
Week 2 - UND
Week 4 - UND
Week 8 - UND
13/10/15 Week 12 - UND
19/11/15 - SVR4
8/1/16 - SVR12 !!!!!

Offline badbradley

  • Member
  • Posts: 294
Re: Viekira Pak for those who failed Harvoni
« Reply #1 on: July 28, 2015, 08:20:32 pm »
sickpuppy,
        That is not a recommended regimen for Harvoni failures.

http://www.hcvguidelines.org/full-report/retreatment-persons-whom-prior-therapy-has-failed
http://www.easl.eu/research/our-contributions/clinical-practice-guidelines/detail/recommendations-on-treatment-of-hepatitis-c-2015/report/4
     
I know of one person on the forum who failed Harvoni being retreated with this regimen.
Brad
« Last Edit: July 28, 2015, 10:29:40 pm by badbradley »
Geno 1a
Sov/Oly 12wks - relapse
Har/Riba 12wks
Alt-16  Ast-17 SVR - 12
Alt-15  Ast-14 SVR - 24

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,546
  • Get tested, get treated, get cured, fight Hep c!
Re: Viekira Pak for those who failed Harvoni
« Reply #2 on: July 30, 2015, 02:46:54 am »
The reason is the Ledipasvir component of Harvoni is in the same class of one if the meds in Viekira pack and while Sovaldi do not create resistance ledipasvir does create resistance to the same class of meds

Ledipasvir is an HCV NS5A inhibitor as is Ombitasvir
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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