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Author Topic: Early response (undetected <2 weeks) meaning?  (Read 4433 times)

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Offline sickpuppy

  • Member
  • Posts: 51
Early response (undetected <2 weeks) meaning?
« on: August 06, 2015, 07:01:40 am »
Does it mean anything if someone gets to undetected in 2 weeks or less?
GT1a - TX-naive

Baseline:

16.2 kPa
ALT: 61 iu/L
ALP: 74 iu/L
Albumin: 38g/L
Bilirubin: 27 umol/L
Platelets: 80
VL: 792,000
History of 4 violent varices bleeding episodes and splenomegaly present.

21/07/15 - TX start - Harvoni + Ribavirin 12 weeks.
Week 2 - UND
Week 4 - UND
Week 8 - UND
13/10/15 Week 12 - UND
19/11/15 - SVR4
8/1/16 - SVR12 !!!!!

Offline dragonslayer

  • Member
  • Posts: 873
Re: Early response (undetected <2 weeks) meaning?
« Reply #1 on: August 07, 2015, 10:04:29 am »
Does it mean anything if someone gets to undetected in 2 weeks or less?

As Lynn said elsewhere, on treatment testing has little correlation with eventual SVR. That is why with modern treatments, it's not part of the treatment protocol/guidelines.  So, to answer your question,  it means very little with regard to eventual svr status.
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

 


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