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Author Topic: Started 12 weeks of Viekira-Pak with ribavirin this morning!  (Read 17956 times)

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Offline w_ink

  • Member
  • Posts: 31
I was lucky enough to get one of AbbVie's Virkira-Pak vouchers through my doctor. My insurance co (Blue Shield of California) had denied both Harvoni and Viekira, determining I wasn't sick enough...ugh. I had to go off my estradiol patch, but the bucketload of hot flashes every day will be worth it if I can get rid of the HCV.

So far (1/2 day...heh), so good!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline Phoenix

  • Member
  • Posts: 30
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #1 on: June 25, 2015, 09:01:15 pm »
Best of Luck to you.  So far it's a piece of cake!
Phoenix    Start 6/13/15 - 24wks V-Pak w/rib
GT 1a  FibroSure: F4, A3
5/28/15 BaseLine- AST:141, ALT:143, VL:7.7 mill
6/30/15 Aft 2 Wks -AST:31, ALT:20, VL:not tested
7/14/15 Aft 4 Wks -AST:24, ALT:18, VL:UNDETECTED
8/12/15 Aft 8 Wks -AST:22, ALT:14, VL:UNDETECTED
9/9/15 Aft 12 Wks -AST:21, ALT:13, VL:UNDETECTED
10/7/15Aft 16 Wks -AST:24, ALT:14,VL:UNDETECTED
11/2/15Aft 20 Wks -AST:19, ALT:14,VL:UNDETECTED
11/23/15Aft24Wks-AST:24, ALT:14,VL:UNDETECTED
6/6/16 Aft  51wks AST:28, ALT:26,VL:UNDETECT

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #2 on: June 26, 2015, 02:31:53 am »
Thanks, Phoenix!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #3 on: July 01, 2015, 07:50:45 am »
All the best! I'm 14 weeks into a 24 week program. Over half way! Stay the course, it's worth it.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline dearprudence

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  • Posts: 121
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #4 on: July 01, 2015, 10:16:29 am »
Good luck W_ink!  I am into my 7th week of 12 on viekira pak and ribavirin.  Virus Undetected at week 3!   new blood work just in -  AST 11 and ALT 7 - hemoglobin 12 .  doc says it's all good! No really bad side effects at all.  Stay with it!

Offline w_ink

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  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #5 on: July 01, 2015, 05:23:35 pm »
Philadelphia & DearPrudence,

Thanks so much for the words of encouragement! Today's my 7th day on the VPak and Riba. Eleven weeks to go. Mostly, I've been tired, and a bit of nausea the last two days, but I'm so glad we're able to have a treatment with such a good chance of getting rid of this virus. We'll beat this!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline dearprudence

  • Member
  • Posts: 121
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #6 on: July 03, 2015, 02:02:59 pm »
Philadelphia & DearPrudence,

Thanks so much for the words of encouragement! Today's my 7th day on the VPak and Riba. Eleven weeks to go. Mostly, I've been tired, and a bit of nausea the last two days, but I'm so glad we're able to have a treatment with such a good chance of getting rid of this virus. We'll beat this!
sharing and encouraging and learning is what this forum is all about - I am so glad I found it - I know I am not going through this alone. Yes, we will beat this!

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #7 on: July 09, 2015, 12:24:41 am »
End of week two with a few side effects from the ribavirin. Weakness and fatigue, especially walking up hills and stairs; a bit of nausea; lack of appetite. But overall, I'm really positive. Found out today my viral load at start of treatment was 18,100,000. It was 11,000,000 six months ago. I had my two week blood work done today, so I'll know in a week or so. Takes a while for the viral-load lab to go through. I'm hoping my numbers have dropped.
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline dearprudence

  • Member
  • Posts: 121
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #8 on: July 10, 2015, 12:05:44 pm »
w-inkj --- don't forget to drink plenty of water - hydration is key.

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #9 on: July 10, 2015, 04:35:17 pm »
Yah, I've been drinking more than 2 liters a day, more like 2.5. If I don't, I get more headachy.
 
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #10 on: July 10, 2015, 05:43:40 pm »
I had those sx with the drugs too. The first couple of weeks were the worst for me. Looking forward to hearing your results - they should give you a boost.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #11 on: July 10, 2015, 08:50:42 pm »
Thanks, P. & P. I really appreaciate your support!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #12 on: July 22, 2015, 03:22:35 am »
Great news! Though my hemoglobin keeps falling (start=14.9-->week two=11.6-->week three=10.3), as does my RBC count (start=4.46-->week two=3.53-->week three=3.25), my viral load went wayyyyy down! I am psyched!

AT START: HCV RNA=18,188,000 IU/mL; HCV Log 10=7.260
2 WEEKS: HCV RNA=50 IU/mL; HCV Log 10=1.699



w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #13 on: July 22, 2015, 04:47:44 am »
I've said on the other thread but I'll say it again, congrats!
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Sven

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  • Posts: 11
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #14 on: July 22, 2015, 07:51:05 am »
Hi w_ink,

I think we will move together into the treatment,because i also start the treatment  near in the beginning of july. Also the same like my results,and i'll say this was expected, RBC and hemoglobin to fall.
I've read somewhere that the statistics of Viekira Pak treathment show around 95 % success,this is wonderfull news,i hope no more interferon for the other generations.
I wish you good health and success!
1b,F4,Viekira Pack+RBV-12 weeks

Start treat with:
AST-230, ALT-250
VL 2012-450000, 2015-250000

W3 - AST-45,ALT-42
VL - detected less than 12IU

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #15 on: July 22, 2015, 11:55:12 am »
Thanks, Sven! Here's to a cure!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline sapphire101

  • Member
  • Posts: 238
  • "Stop worrying and start living"
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #16 on: July 22, 2015, 11:31:02 pm »
Side question for you Wink. How is it going without the estradiol patch? LOL any relief yet from hot flash city? Would be nice to come out the other side all done with them.
Sapphire101
Genotype 1a Fibrosis level 1
Viekira Pak with ribavirin 12 weeks
Pre treatment  VL  1.7 million, AST 45 ALT 65
EOT VL not detected, AST 21 ALT 21
12 week SVR not detected,24 week SVR not detected.
Cured! Class of 2015

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #17 on: July 23, 2015, 02:12:09 am »
Hi, Sapphire,

Ha! I was hoping the same thing. My body's just not ready to give up the ghost. I have about 10 or 15 a day, which I can deal with. It's the ones at night that mess me up. Right before a flash, about 10-20 seconds, I get this prodromal sense of dread, like something awful has happened, even when I'm asleep. It wakes me up. I think, Oh no, something terrible is going down! Then I realize, Oh, it's another freaking flashzilla.

But mostly it's just another little side effect, a little nausea here, a little breathlessness here, a little inexplicable rage over there, a cough, a headache, itchies, some insomnia, but I don't care! Because my viral load is 50 and falling, and my liver is doing a little tap dance of appreciation. Oh, and bonus, my joint pains are diminishing!

Starting my second month tomorrow. One third done, two thirds to go!

Here's to getting great news on your 12-week labs!  :D
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline ms.nomoreC

  • Member
  • Posts: 45
  • Be patient: your time will come. M. Castillo
    • Blog: Noma Says
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #18 on: July 23, 2015, 12:48:39 pm »
Hi w_ink,

Great news on your lab results. We're almost there!
ms.nomoreC


SVR DECEMBER 1 2015
"C" for Cured!

Genotype 1a
F3
Diagnosed 1997
Probable infection 1970
Pretreatment VL 6.6, WK 2 ? WK 6 0 Wk 8 detectable
EOT VL: 0, undetectable
ALT 69, WK 2 26, WK 6 27, EOT 18
AST 75, Wk 2 25, WK 6 28, EOT 19
GGT 113, WK 2
Bilirubin EOT:.6
AFT: Pretreatment 9.2, EOT 4

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #19 on: August 23, 2015, 06:39:51 pm »
I am jumping for joy. Got my 8-week labs back. And this is what I've been waiting for:

Name      Value      Reference Range
Test Information:            
Hepatitis C Quantitation      HCV Not Detected      IU/mL
HCV log10            

So happy! Three more weeks to go till EoT!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline ms.nomoreC

  • Member
  • Posts: 45
  • Be patient: your time will come. M. Castillo
    • Blog: Noma Says
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #20 on: August 23, 2015, 06:59:17 pm »
Terrific news W_ink! Not too much longer now!

After this, (my EOT is Sept. 7th) I intend to continue to baby my liver while it heals from 46 years of HCV attack. Can't wait to see how I feel once my RBC, hematocrit, and hemoglobin return to normal.

It will be interesting to see how we all feel without HCV and without side-effects!


ms.nomoreC


SVR DECEMBER 1 2015
"C" for Cured!

Genotype 1a
F3
Diagnosed 1997
Probable infection 1970
Pretreatment VL 6.6, WK 2 ? WK 6 0 Wk 8 detectable
EOT VL: 0, undetectable
ALT 69, WK 2 26, WK 6 27, EOT 18
AST 75, Wk 2 25, WK 6 28, EOT 19
GGT 113, WK 2
Bilirubin EOT:.6
AFT: Pretreatment 9.2, EOT 4

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #21 on: August 23, 2015, 07:31:22 pm »
We finish on the same day ms nomoreC :)
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #22 on: August 24, 2015, 12:01:40 am »
ms.momoreC & Philadelphia, I hope for all of us a sustained cure. I'm right behind you!
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

Offline dearprudence

  • Member
  • Posts: 121
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #23 on: August 24, 2015, 10:25:20 am »
Good luck to all of you coming down the home stretch!  Can't wait to see your eot results!
I finished 8/2 and eot was virus undetected. Waiting for 12 week svr now.
WE WILL BEAT THIS!
Prudence

Offline LF98

  • Newbie
  • Posts: 2
Re: Started 12 weeks of Viekira-Pak with Motoriba on 8/7/15
« Reply #24 on: August 25, 2015, 02:46:47 pm »
Just wanted to say that I am almost 3 weeks in. Took a lab at two week mark and ALT and AST are 10 and 11. They were both in the 80s prior to starting treatment. I have geno 1a and am doing VP plus riba. Is this a good sign that it's working?

Offline w_ink

  • Member
  • Posts: 31
Re: Started 12 weeks of Viekira-Pak with ribavirin this morning!
« Reply #25 on: August 25, 2015, 03:31:31 pm »
LF98, Sounds good! Do you have any other lab results, like hemoglobin? Did they do a viral load count? Don't sweat it if they didn't. Everyone does labs differently. But your AST and ALT are great. Best advice I got when I started was to drink plenty of water and to take the pills in the middle of a meal, not before or after.
w_ink: 56-years old, female
1976: contracted hep B, likely co-infected with HCV
2007: diagnosed
2011: accepted into clinical trial, dropped out when the required biopsy resulted in a huge hematoma
Genotype: 1a
Fibrosis: 1
Start of treatment with V-Pak and RIBA: 6/25/2015
ALT at start=31; AST at start=24
HCV RNA at start=18,188,000 IU/mL; HCV Log 10=7.260
ALT at 2 weeks=13; AST at 2 weeks=13
HCV RNA at 2 weeks=50 IU/mL; HCV Log 10=1.699
HCV RNA at 8 weeks=Undetected

 


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