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Author Topic: Started Viekira Pack no ribavirin  (Read 14201 times)

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Offline mcmaklin

  • Member
  • Posts: 52
Started Viekira Pack no ribavirin
« on: August 20, 2015, 03:41:16 am »
Hello, Just would like to say thank you to all people I was asking before my treatment. Most of you were taking this with Riba.
I am on Viekira Pack day 3.  I started this in Clinical Trials in Poland.
https://clinicaltrials.gov/show/NCT02219490

You know, I am taking this as Vitamin C, there are no side effects at all. Nothing. I even do have much more energy than I had before. I have a feeling that those people from Harvoni are doing only a good marketing because Viekira Pack is very good. No single headache, tiredness, nothing!:)

Will it be like that  as light after a week or 2 or should I  expect anything?


40 y.o, Genotype 1b, TT, Starting from 1400000 VL, F1 almost F2, treatment naive
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started Viekira Pack no ribavirin
« Reply #1 on: August 20, 2015, 04:36:10 am »
Without ribavirin, you might notice some fatigue, nausea and headache.  Perhaps a few other assorted side effects. Once my ribavirin was reduced I felt great. I'm on 24 weeks - three weeks left. :)
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline mcmaklin

  • Member
  • Posts: 52
Re: Started Viekira Pack no ribavirin
« Reply #2 on: August 20, 2015, 05:28:01 am »
When those effects could start? 3 days and nothing bad happens:)
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started Viekira Pack no ribavirin
« Reply #3 on: August 20, 2015, 05:49:36 am »
I noticed some side effects after about two weeks. Nothing too bad though.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline mcmaklin

  • Member
  • Posts: 52
Re: Started Viekira Pack no ribavirin
« Reply #4 on: August 20, 2015, 07:34:24 am »
but you are taking Ribavirin additionaly
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Philadelphia

  • Global Moderator
  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Started Viekira Pack no ribavirin
« Reply #5 on: August 20, 2015, 07:38:21 am »
I am, yes. There are others here who are not on riba though and they may give you a different opinion.
Logged
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline bkmusic

  • Member
  • Posts: 31
Re: Started Viekira Pack no ribavirin
« Reply #6 on: August 20, 2015, 07:52:48 pm »
Week 7 Viekira no ribavirin. Glad you are having a good first week the SE come and go and you may get them later in the treatment road but they are tolerable.

Best wishes on the journey fellow viekiran.
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Offline drummerman

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  • Posts: 538
  • For those regarded as warriors....
Re: Started Viekira Pack no ribavirin
« Reply #7 on: August 20, 2015, 10:32:40 pm »
Its the riba that causes side effects in some people.

One of my nurses told me (when I hesitated tx) that it was riba interacting with peginterferon that gave me my previous baaaaadddd sides.  She was right in my case..... riba by itself is uncomfortable but so much easier that old school riba/peg.

I've seen lots of people not bothered by riba at all, others have issues.  I experience anxiousness, being out of breath (not anemic though) and itching.   The itching is weird, its usually on my face but never in the same place on my face.  I scratch it and it stops..  others have said "don't scratch", but it doesn't bother me as I never develop the "riba rash".

I had no side effects the 1st week at all,  2nd and 3rd were the worst , and I even developed "weepiness" where things on tv and events made me want to cry.  That has lessened a great deal.

In fact every day is a little better.  Knock on wood.

dm
Logged
Diagnosed07
Interferon/riba 2008 - non-responder
5/16/15 - AST -34
ALT - 35_ HCV RNA - 10,783,000
 7/6/15 - started viekira/riba
8/11/15  Week 5 <15 vl,  AST 18, ALT 18
9/11/15 Week 9  "HCV NOT DETECTED"!
AST 16, ALT 11.  10/16/16 - 2 weeks post EOT = "HCV NOT DETECTED!   AST - 18,  ALT 14
12/29/15 -12 wk EOT-HCV NOT DETECTED! AST 23, ALT 15
3/26/16 - 24 wk post EOT - HCV NOT DETECTED!! AST 19, ALT 21
1 yr eot - AST 20, ALT 17

Offline mcmaklin

  • Member
  • Posts: 52
5th week on viekira pack, question about larynx pain,
« Reply #8 on: September 29, 2015, 07:03:31 am »
Hi, I am on the 5th week of Viekira Pack no Riba. No side effects at all - I am feeling much better and much more energy. The only thing I would like to ask because for last 5 days I have a feeling as my larynx on the left site is painful especially while eating and drinking. It is the same for a few days already. It feels as if I have a bruise there. It is the same for a few days. No other side effects. Could it be a side effect of treatment? I never had anything like this. Apart from that I feel very well.



Genotype 1b , started treatment with Viekira Pack 18th of Aug 2015, initial VL 1400000, after 2 weeks VL 120,  after 4 weeks VL below the possibility to measure it. GGTP went normal, it was always around 90.
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline dearprudence

  • Member
  • Posts: 121
Re: Started Viekira Pack no ribavirin
« Reply #9 on: September 29, 2015, 08:22:16 am »
Hi mcmaklin,
I finished my vpak riba about 2 months ago - ubdetected since week 4! - and yes, I had similar sides with my throat. It would kind of close up when eating or talking - I would be in the middle of a conversation and start coughing and not be able to speak - would sip water and pop some cough drops. No real pain though, just kind of felt thick.
hope that helps.
Prudence
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Offline mcmaklin

  • Member
  • Posts: 52
Re: Started Viekira Pack no ribavirin
« Reply #10 on: September 29, 2015, 09:15:15 am »
But I Am not taking RIBA and this is only on the left side and not that bad as you describe..
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Started Viekira Pack no ribavirin
« Reply #11 on: September 29, 2015, 05:31:12 pm »
Hi mcmakllin,
Maybe mention to your tx nurse or specialist? I haven't had that sxs I am on ribas with my v pak. Good luck. Cal :)
Logged
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline dearprudence

  • Member
  • Posts: 121
Re: Started Viekira Pack no ribavirin
« Reply #12 on: September 30, 2015, 08:58:06 pm »
Quote from: mcmaklin on September 29, 2015, 09:15:15 am
But I Am not taking RIBA and this is only on the left side and not that bad as you describe..
Hi mcmaklin,
good suggestion from Cal - talk to someone about this - could be a vpak side effect, but who knows? Everything I felt during treatment I attributed to the treatment itself. 
could be something totally unrelated and best checked out.
good luck !  Prudence
Logged

Offline mcmaklin

  • Member
  • Posts: 52
Re: Started Viekira Pack no ribavirin
« Reply #13 on: September 30, 2015, 08:59:11 pm »
Hello it was unrelated! Now is better almost normal!
Logged
2ndTreatmnt  geno 1b- Vosevi 12 weeks - SOT Sept 12 2018 to EOT Dec 5 2018. Pre-treatment - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90, bilir 16. 2 weeklabs:VL 49, ALT 26, AST __, GGT 53. Bili 21, 4 weeklabs:VL <15, GGT42 other normal, 5weeklabs:ALT 17,AST 27, Bili 11.8,  ALP 68, GGT 36 ... VL 12,   6weeklabs ALT 19, AST 26, Bili 16,20, GGT35, VL<12

1stTreatm Compl. Viekira+Exviera no Riba Nov2015. 1b,TT,F1, 1400000U Relapsed 4 weeks EOT

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Started Viekira Pack no ribavirin
« Reply #14 on: September 30, 2015, 09:22:59 pm »
McMaklin,
Good news. What a pesky thing to have. Cal :-*
Logged
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline dearprudence

  • Member
  • Posts: 121
Re: Started Viekira Pack no ribavirin
« Reply #15 on: October 09, 2015, 01:12:34 pm »
Quote from: mcmaklin on September 30, 2015, 08:59:11 pm
Hello it was unrelated! Now is better almost normal!
great news!
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Offline lporterrn

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  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: Started Viekira Pack no ribavirin
« Reply #16 on: October 22, 2015, 06:32:09 pm »
The FDA just posted a warning about Viekira Pak and Technivie: http://www.fda.gov/Drugs/DrugSafety/ucm468634.htm
Logged
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter
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