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Author Topic: Cal on Vierkira Pak & Ribas  (Read 367525 times)

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Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #500 on: October 28, 2015, 08:40:44 pm »
Thank you, Cal.  People like you change the world.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Scoutdoy

  • Member
  • Posts: 452
Re: Cal on Vierkira Pak & Ribas
« Reply #501 on: October 28, 2015, 08:46:17 pm »
Good for you cal, can we stream the session so we can hear what you said to them?



Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #502 on: October 28, 2015, 08:53:12 pm »
take it to them beeouches yo  :)
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #503 on: October 29, 2015, 12:38:14 pm »
   Cal, Good to hear. Looks like it got Your spirits up also! :o ;D LOL!! Hold Your head up, tuck Your chin in , grab hold of that rope , and give 'em full spurs until they come around to Your way of thinking! 8) Give 'em hell and then some! Do us all proud, I know You will!!! :) ;) :D ;D 8)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline byebyeC

  • Member
  • Posts: 286
Re: Cal on Vierkira Pak & Ribas
« Reply #504 on: October 29, 2015, 01:02:54 pm »
Thank you Cali!

You're an extraordinarily strong and wonderful person.

Much much love,
Marianne
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #505 on: October 29, 2015, 04:33:45 pm »
Cal, that was amazing that you did that... Now who is the motivational speaker? Ha.
Speaking from experience and your heart always wins.

I can't think of anyone more kind, compassionate yet firm to deliver the message for those who need a voice.  You are an asset to the world!  Love,  Bree
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline BillT

  • Member
  • Posts: 573
Re: Cal on Vierkira Pak & Ribas
« Reply #506 on: October 29, 2015, 05:49:00 pm »
You go Cal.The way I see it is that nobody should be denied regardless of if they're F0 or F4.We're talking about peoples lives.They wouldn't deny cancer treatment to somebody in any stage so why this?If we're willing to do what it takes and fight for our lives then money shouldn't be a factor in their decision.Ok,Rant over. :)
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #507 on: October 29, 2015, 06:30:07 pm »
Oh boy,
Thanks everyone for your encouragement and kindness. We are doing everything we can to get equitable access. If it goes through, I hope we can turn around the shame of our Government and be a Medical model for the world. Not that I care what people think of our Government ::) I think very little right now.

I gad a big RIBA over did it crash yesterday. I got so stressed, I am doing too much and I am on increased ribas, I must be mad.  :P rest today. Cal :D
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline byebyeC

  • Member
  • Posts: 286
Re: Cal on Vierkira Pak & Ribas
« Reply #508 on: October 31, 2015, 04:17:35 pm »
God bless you Cali girl! I know just how awful this was for you already. Bless you with strength, courage, if not joy, at least a bit of laughter and lots and lots of hugs, love and help from those wonderful minions of yours! :D

<3 Marianne
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #509 on: October 31, 2015, 07:03:28 pm »
Thanks. Marianne,
You're a real pal. Thank you for caring. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #510 on: October 31, 2015, 07:07:37 pm »
Hi all,

I have a new symptom it's been developing over the last week. I have pain. Sharp and prolonged  in seemingly random places. Some are joint but most are in the bone? Anyone else experienced this? If course hoping it passes but also worried it's RIBA. I was also thinking that the immune system could be attacking itself, as I have auto immune issues?what do you think? Cal :-\
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #511 on: October 31, 2015, 07:30:30 pm »
symptoms can be so odd and varied.  I should probably keep quiet cuz I'm always speculating.  Could be any of the things you mentioned.  My wife used to get the symptoms you are describing.  She had them for most of her life.  They were explained as strong, sharp pain in the joints that would move around her body.  She did have tests that indicated her immune system was a bit hyper and that those and other stuff she had going on could have been auto immune.  Have you ever had a C-reactive protein test or, any kind of auto immune activity tests done?  Then, the meds can cause all sorts of things.  As has been reiterated on this forum umpteen times, our immune systems are suddenly operating in a body now devoid of hep.  It had it's hands full and then in a blink...virus gone...or very diminished.  Just sayin'.  You've had a heck of a go Cal...pulling for you.

I'm wondering if anyone has had bleeding or pour clotting of blood after tx.  I just had oral surgery and have had bleeding issues.  My platelets are perfect based on a CBC I had the day before.  Weird....scary halloween chit...
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #512 on: October 31, 2015, 09:42:02 pm »
Thanks Beto,
Yeah I have a raft of auto immune issues and antibodies for just about everything! I think I mentioned I get my thyroid removed ASAP after tx.  I think your hypothesis if the lonely immune system looking fir something to do fits well, along the lines I was thinking. I'll just keep moving and shaking ::)cal
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Scoutdoy

  • Member
  • Posts: 452
Re: Cal on Vierkira Pak & Ribas
« Reply #513 on: October 31, 2015, 10:26:02 pm »
Cal , it's amazing what happens to the human body when the immune system goes wacky. I personally think that the HCV meds weaken our immune systems a lot and make it go a little crazy. I am trying to do things to boost my immune system since the EOT. Have no idea if it is true or not. One thing I do know is during treatment I lost my appetite and was experiencing some vision issues. Nothing major, but since treatment ended my vision went back to normal and my appetite is out of control. I love to eat so I am enjoying that part...lol...have put on 8 pounds in 13 days! Now I am back to normal weight. Who knows what is or isn't related to HCV or the treatment itself. It's a crap shoot. Hopefully when you get done with treatment your immune system will bounce back. One can hope anyway!


Go Royals
Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #514 on: November 01, 2015, 12:55:45 am »
 Hey Guys, My two cents! The extremely strong antivirals we have been taking actually gives the immune system a break. But being a workaholic, it stays in hyper mode because that is what it has known basically forever because of the virus! It attacks any little thing that it sees as a threat because it has to do something. It never takes time off,takes a vacation, or even takes a break. Not to mention the different Meds. we are taking. Especially Ribavarin. Then there is the autoimmune issues and other health problems We have been ignoring or don't even know that We have!!!!!!One needs to take into account the OTC Meds. and supplements also. There are way to many variables to take into account, it boggles the mind!!! Don't forget diet, environmental factors, cleaning products, ETC.ETC. So many things that We take for granted that affect our very being. But, that is just My two cents.
 
 LIKE MY DAD USED TO TELL ME ALL THE TIME, USE YOUR HEAD FOR MORE THAN JUST A HAT RACK. YOU WOULD BE SURPRISED WHAT IT CAN DO FOR YOU 8) 8) 8)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #515 on: November 01, 2015, 01:03:01 am »
Cal , it's amazing what happens to the human body when the immune system goes wacky. I personally think that the HCV meds weaken our immune systems a lot and make it go a little crazy. I am trying to do things to boost my immune system since the EOT. Have no idea if it is true or not. One thing I do know is during treatment I lost my appetite and was experiencing some vision issues. Nothing major, but since treatment ended my vision went back to normal and my appetite is out of control. I love to eat so I am enjoying that part...lol...have put on 8 pounds in 13 days! Now I am back to normal weight. Who knows what is or isn't related to HCV or the treatment itself. It's a crap shoot. Hopefully when you get done with treatment your immune system will bounce back. One can hope anyway!
Hi Scout,
Like Tommy said the immune system has been a workaholic all these years and is just hovering....... My friend who txed and cleared on ifn and ribas was put on steroids for 4 months post tx because her immune system was attacking her bones! If worked. I won't hesitate to see my immunologist and ask for some assistance. BTW I am eating like crazy! I don't know why??? I haven't finished tx yet! Cal :)

Go Royals
Scout
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #516 on: November 01, 2015, 01:27:42 am »
Interesting what Tommy said about cleaning products and environmental.  I got sick a couple of times after doing some cleaning (maybe my body hates it;).... once during treatment and then this week I painted a wall on separate days and had headaches and felt sick for days.  I also had a PDT (blue light photo-dynamic treatment on my face for sun damage).  Between the paint and the blue light I've been feeling awful.... so much so it scared me.

I woke up this week in the middle of the night with leg cramps and a jabbing pain in the top of my right foot.  It went away but, whoa.  My nurse practitioner friend has me on magnesium and trace minerals which helps.  She recommends boron too.

The other thing that I've noticed is that my eyes look a little like road maps.  I had a burst blood vessel during treatment (was told not related although never happened before) and now the blood vessels are slightly enlarged.  My eyes are whiter (not an off color) but those red eyes are strange.  I'm going to see my internist this week.  Pretty sure all of this is body reactions post treatment.   Nothing life altering but a bit scary.
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #517 on: November 01, 2015, 01:27:59 am »
 Damn, more references about food. I am going to gain that 10 Lbs. I lost right back. AND, the holidays are coming up TOO! I guess I won't be making any of My low calorie Pecan Pie this Year, ROTFLOL!!!!! Think I'll go eat some Halloween candy. Since the weather was so bad here I only had about a dozen kids Trick Or Treating this Year. Damn there is a butt load of candy left. I'm sure it is all low calorie just like My pecan Pie ::) ::) ::)  NOT!!!!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #518 on: November 01, 2015, 01:34:23 am »
I LOVE pecan pie!!!  Can't wait till Thanksgiving to get some.

I didn't have one trick or treater.  The kids grew up.  I had those little containers of organic apple sauce if some showed up.  Maybe that's why... don't go to that house, they will give you something healthy! ha. 
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #519 on: November 01, 2015, 03:44:57 am »
Bree,
Sounds like post tx stuff, I am having the shooting pains now. Take all the magnesium and supps, doing everything you can get back to homeostasis. DOn't worry this is normal stuff my darling friend. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #520 on: November 01, 2015, 11:44:59 am »
 Bree, I seem to be having the leg cramps and pains more so now post Tx. also. Never really had them before unless it was after some strenuous Hiking at My place out west. Climbing in & out of the canyons checking out fossils in the rocks and tracking animal sign. I am starting back up on My supplements again. Checking out correct amount of Potassium and Magnesium and any contraindications that go with them. I usually take a lot of Vit. C , so Calcium-Magnesium is a given as Vit. C leeches Calcium. And smoking takes a lot of Vit. C out of Your system too. Boron???? I have to check into that.Going to set up visit to G.P. to get an overall check up and physical as well as address some issues I have been ignoring for some time now. Going to ask him and G.I. about trace minerals and such. I have not been to this G.P. before, but he comes highly recommended. He was one of the top Trauma Guys next door at the Hospital for years. I have been told that He is versed in Eastern Medicine as well as highly trained in Western Medicine and has no aversion to herbals & supplements either. He is also trained in Acupuncture and Acupressure treatment as well.
  BTW, nobody else eats the pie so , IT IS MINE , ALL MINE!!! LOL! Do You think You are reacting to the chemical or are You allergic to the work? Or both? :-\ :P ??? :o :D
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #521 on: November 01, 2015, 11:51:49 am »
Okay, maybe I'm reading too fast or my vision is a bit wonky right now.  But when I was reading your post, I thought you said, "Vit. C, leeches, Calcium".   :o

I'm all, "whoa there, Cowboy.  Let's hold off on the leeches for a while."   :o ;D
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #522 on: November 01, 2015, 12:05:07 pm »
Thanks Cal!

Tommy check out ConcenTrace Trace Mineral Drops (by Trace Minerals Research) on Amazon.  Taste yucky but I'm desperate enough to drink a little mixed with water or disguise it in things.
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #523 on: November 01, 2015, 12:06:46 pm »
  HMMM, Blood letting for high iron issues!!! Never thought about that one. Back to the Dark Ages once more ;) :-\, Hell I'll try anything once , and the good stuff repeatedly. WAIT, hold up a minute! if My memory serves Me correctly, that is what got Me INTO this predicament in the first place ;D ;D ;D ;D ;D
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline slats1056

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  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #524 on: November 01, 2015, 12:08:31 pm »
 Bree, what about the last sentence of My post? :) :) :) :)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Bree

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  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #525 on: November 01, 2015, 12:09:58 pm »
Bree, what about the last sentence of My post? :) :) :) :)

Definitely allergic to both :) 8)
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Bree

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  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #526 on: November 01, 2015, 12:12:31 pm »
And you have to share the pie!  8)

I grew up in the south, so pecan pie was a part of my lifestyle.  When I was back visiting a couple of years ago, I bought a pie and ate the whole thing!  (Not in one sitting but I had it with breakfast lunch and dinner for two days).  Warmed with ice cream on top!  so there!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline slats1056

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  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #527 on: November 01, 2015, 12:27:30 pm »
 How in Hell am I supposed to eat healthy when all these references of comfort food keep popping up?
 Re.: The pie sharing!!! Have You ever watched Stir Crazy with Gene Wilder and Richard Pryor? The big guy Grossberger when he was eating & Gene walked up to him? He put His arms over His food & started growling at Gene when He got close to Him. THAT IS ME WITH PECAN PIE!!!! Especially when I made it!!!! :P :P :P :P
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline slats1056

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  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #528 on: November 01, 2015, 12:29:00 pm »
 For You!!! I will make an exception though :)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #529 on: November 01, 2015, 12:57:12 pm »
Yea, I go for healthy but not perfect at it.  I haven't seen that one but one of my favorite movies is Gene Wilder and Richard Pryor in Silver Streak.

Have a great day yall!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline beto

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  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #530 on: November 01, 2015, 01:17:12 pm »
If you are taking vita C it is usually buffered with calcium and magnesium.

Yes Tommy, best way to deal with iron overload (on one of the best ways) is giving blood.  Since nobody wants our blood, phlebotomies (blood letting) are the ticket if too high.  Probably, back when they bled folks, they were gaining at least some benefits.  A male 40 or over years old that drinks and eats a lot of red meat  might well have high blood iron that was affecting his health.  The liver would be one of the main organs to suffer.  I have said before, harvoni seemed to lower mine quite a bit.  Plebs I would think would be contraindicated on and EOT of these meds...maybe someone knows the answer.  Many alcoholics have high ferritin.  BTW am not advocating them here, just sharing info.

I had plebs over the years because of High ferritin.  I always noted a drop in AST/ALT after getting levels down.

Pecan pie is also know as vitamin PP right?  :)
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline byebyeC

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Re: Cal on Vierkira Pak & Ribas
« Reply #531 on: November 01, 2015, 02:19:09 pm »
I love how our posts go all over the place from scientific breakthroughs, Dr.'s lack of knowledge (or concern) of them, to just being our silly, goofy pea-can pie loving selves!

Else, bahaaaa! Leeches! You know Tommy meant a good ole solid electro-shock treatment followed by the leeches to get the iron out ;D Oy to the VAY! :D

Because I've been reading so much on the peripheral neuropathy, I've ran into some really interesting new research on how the anti-nausea med odansetron/zofran ameliorates brain fog in hep c patients! Pretty wild stuff those giant brained wonderful folks out there are figuring out!

For Tommy, Bree and Kim (if I remember correctly, BIG IF), y'all got/have joint pain and cramps post tx. This monster out of our systems, then them rebuilding, and, all at once, finally able to do so,  some of us got peripheral neuropathy that got pretty bad in the extremities. But, this research is showing this is a systemwide issue affecting the small and medium sized veins and vessels in different patients in different places, but basically it happened to us all to some degree, somewhere... Just a little more light (bwahahaahaa) reading... Also, this is a different link from the same researchers fyi...

Long winded story short, perhaps, God willing, all those veins and vessels regenerating just hurts whilst it's happening cause it's so freakin' MUCH going on. That's my hope, my prayer, my dream for us all.

http://www.hindawi.com

<3 Marianne
« Last Edit: November 01, 2015, 02:30:53 pm by byebyeC »
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #532 on: November 01, 2015, 04:47:41 pm »
Hi  Tommy,
I like the idea if a GP also embracing alternative medicine. I agree with Bree you need a full profile then you can supplement away. Getting those electrolytes balanced is important.
As for pecan pie, I had some once and it was very sweet, I don't know if it was the authentic one guys are talking about. I am always seeing you guys in Diners in movies eating pie. We aren't so big on pie here! 


As fir blood letting, well you guys really are behind the times down there in the Deep South he he Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #533 on: November 01, 2015, 04:53:55 pm »
Hi Beto,
Do you have haemochromatosis? Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #534 on: November 01, 2015, 04:58:10 pm »
Hi Marianne,
How are you beautiful one?

I really want yo read your link, but it only takes me to a website with a few different publications on it? It sounds really interesting. Can you re post the link to it please, pretty please with sugar or stele ya on top? I have large and small vein neuropathy and am having lots if pain, so would live to read it. Thanks. Cal :-*
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #535 on: November 01, 2015, 08:50:31 pm »
Hey Cal,

No I do not have the genetic marker for hemochromatosis...but sported pretty high numbers for a while.  Not uncommon for anyone with liver issues, especially middle aged men.  They helped.  I did not do a ton of them because I responded well.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #536 on: November 01, 2015, 11:23:35 pm »
Beto,
That's good, it's another complication on tx and for HCVers. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

  • Member
  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #537 on: November 01, 2015, 11:39:47 pm »
Day 74 (11 weeks Thursday) RIBA cough and palpitations I can feel the HB dropping. Yukon. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline KimInTheForest

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  • Believe in yourself
Re: Cal on Vierkira Pak & Ribas
« Reply #538 on: November 02, 2015, 01:49:17 am »
Day 74 (11 weeks Thursday) RIBA cough and palpitations I can feel the HB dropping. Yukon. Cal :)

Just 10 more days, Cal. You can do it! Then you'll be on easy street. :)

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #539 on: November 02, 2015, 02:42:30 am »
Oh Kim,
I'm doing another four weeks aster my 12, because of the resistance issues. Even though I still don't have them back yet 12 weeks later!

So I'm counting down to 12  then starting another month countdown. I am here now so I'll give it all I've got.

I don't even feel that bad about it now. I was really upset at first but it is what it is.
I learnt of a Viekira relapse today, the first one I've heard of. So it makes more sense to tx the hell out of it.

I am getting pain a lot now, in my joints and just random places >:( don't know if it's the ribas. I have an FBC AND LFT tomorrow and results Thursday when I see my specialist. Ho hum Dudley dum! Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #540 on: November 02, 2015, 10:20:45 am »
Beto,
That's good, it's another complication on tx and for HCVers. Cal :)

Cal,

The high ferritin was during my HCV years.  Harvoni actually seemed to lower it...which was amazing and as far as I was concerned, a good thing.  Of course, I can't be sure it was Harvoni but what else could it be.  For some on the meds that are anemic, this could be unfavorable.  Another curiosity that we will know more about down the road.  I posted about this, but no one else reported a similar observation, but then, not many docs were checking for it.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #541 on: November 02, 2015, 10:41:07 am »
Day 74 (11 weeks Thursday) RIBA cough and palpitations I can feel the HB dropping. Yukon. Cal :)

that's because you are kicking butt Cal!!! Eat screaming death hepatitis!!!
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline byebyeC

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  • Posts: 286
Re: Cal on Vierkira Pak & Ribas
« Reply #542 on: November 02, 2015, 12:21:15 pm »
Oopsie! looks like my link above went to nowhere... Thanks Cali girl for letting me know about my misfire :D

here's the proper link, Please Lord help me that I don't repost a bad link cause the cerebrum ain't up to snuff again!!!...

http://www.hindawi.com/journals/jir/2012/236148/
« Last Edit: November 02, 2015, 12:22:53 pm by byebyeC »
GT 1a
VL BOT 7 M
Diagnosed 1980
Treatment naive
12 wk Viekira Pak Riba Started 9/7/15
Alaska 
Pre-treatment labs were ast 42 alt 33 vl 7,162,(eyes are light yellow now)
*Latest alt 19 ast 23! Yay! VL <15 detected

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #543 on: November 02, 2015, 12:39:49 pm »
Cal,

The high ferritin was during my HCV years.  Harvoni actually seemed to lower it...which was amazing and as far as I was concerned, a good thing.  Of course, I can't be sure it was Harvoni but what else could it be.  For some on the meds that are anemic, this could be unfavorable.  Another curiosity that we will know more about down the road.  I posted about this, but no one else reported a similar observation, but then, not many docs were checking for it.

Beto, I used to have high ferritin, high iron. Curiously, it went away on its own.  I adapted a healthy lifestyle - food, exercise, weight, etc., wonder if that did it?  If they test for ferritin (which is what doc does), if that is normal, is the iron then also normal?  I plan on asking my internist when I see her soon.  My liver specialist is to impatient to ask (unfortunately).  I keep getting these surveys to fill out on him (I wonder if others have issues) but I'm afraid to, as he is a resource I might need.
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #544 on: November 02, 2015, 12:42:14 pm »
Oh Kim,
I'm doing another four weeks aster my 12, because of the resistance issues. Even though I still don't have them back yet 12 weeks later!

So I'm counting down to 12  then starting another month countdown. I am here now so I'll give it all I've got.

I don't even feel that bad about it now. I was really upset at first but it is what it is.
I learnt of a Viekira relapse today, the first one I've heard of. So it makes more sense to tx the hell out of it.

I am getting pain a lot now, in my joints and just random places >:( don't know if it's the ribas. I have an FBC AND LFT tomorrow and results Thursday when I see my specialist. Ho hum Dudley dum! Cal :)

Cal, I think that is smart with the 4 weeks if you can get through it and I think you definitely can, as you are an all star trooper!  Might as well get rid of it once and for all and be done with this (bleep)!  Love, Bree 
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #545 on: November 02, 2015, 12:42:43 pm »
Oopsie! looks like my link above went to nowhere... Thanks Cali girl for letting me know about my misfire :D

here's the proper link, Please Lord help me that I don't repost a bad link cause the cerebrum ain't up to snuff again!!!...

http://www.hindawi.com/journals/jir/2012/236148/

Thanks for this Marrianne!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #546 on: November 02, 2015, 12:53:23 pm »
Oopsie! looks like my link above went to nowhere... Thanks Cali girl for letting me know about my misfire :D

here's the proper link, Please Lord help me that I don't repost a bad link cause the cerebrum ain't up to snuff again!!!...

http://www.hindawi.com/journals/jir/2012/236148/

ByebyeC, interesting and very "heady" article.  My take-away, is that it's HepC that either causes are exacerbates these issues, mostly due to inflammation in the cells somehow.  So bring down the inflammation and it will help (unless it's in the cells to stay?).  It's not necessarily a side effect of  Harvoni (or other treatment) it's just with the virus removed, this other stuff (inflammation, etc.) is happening or worsening at least for the short term.  I'm wondering if I am reasoning correctly or don't know what I am talking about.... could be the latter!
 
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline KimInTheForest

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  • Believe in yourself
Re: Cal on Vierkira Pak & Ribas
« Reply #547 on: November 02, 2015, 01:00:58 pm »
Oh Kim,
I'm doing another four weeks aster my 12, because of the resistance issues. Even though I still don't have them back yet 12 weeks later!

So I'm counting down to 12  then starting another month countdown. I am here now so I'll give it all I've got.

I don't even feel that bad about it now. I was really upset at first but it is what it is.
I learnt of a Viekira relapse today, the first one I've heard of. So it makes more sense to tx the hell out of it.

I am getting pain a lot now, in my joints and just random places >:( don't know if it's the ribas. I have an FBC AND LFT tomorrow and results Thursday when I see my specialist. Ho hum Dudley dum! Cal :)

You're right, Cal. It makes more sense to keep going now that you're started rather than possibly have to take a 2nd attempt later. Knock 'em dead.

Have a great day, Cal! :)
kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #548 on: November 02, 2015, 01:01:16 pm »
Marianne,

Great find...love this study.  Besides having PNF issues in my ankles and feet in recent years...I have had many years of CNF complications, and not just talking brain fog, and cognitive issues.  At one point I went through several tests and MS was not ruled out until the end.  I had a dozen symmetrical "lit areas" on my MRI, the neurologist gave me a funny look when he read the scan.  My own doctor suspected the Hep C, but this guy just told me that there was nothing about C and CNS problems in this giant book he held up.  I had a hell of a time...of course ammonia is an issue with liver disease and causes hepatic encephalopathy.  Saw many neurologists.  Thanks...

Bree- Yes, diet does help and I took IP6 for a while too (which was supposed to chelate it)  a vegan diet helped a lot, but for reasons I will not go into, I had to change my diet.  Plebs just worked fantastic for me.  the reference numbers for ferritin are like 18-250-350.  Folks with hemochromatosis are sometimes asked to get under 100.  Liver challenged people are kind of in that camp too.  I had numbers over 800 once.  Before Harvoni I was 250...after 4 weeks 83...amazing.  It is kinda like lifting another burden off the liver.  For anemics..uhh not great.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline beto

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  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #549 on: November 02, 2015, 01:08:27 pm »
B  It's not necessarily a side effect of  Harvoni (or other treatment) it's just with the virus removed, this other stuff (inflammation, etc.) is happening or worsening at least for the short term.  I'm wondering if I am reasoning correctly or don't know what I am talking about.... could be the latter!
 

Bree this idea resonates with me as well.  Hep C creates a lot of issues on our "hard drives" that have to heal over time.  I believe in the tenet of healing that things usually (or sometimes) get a little worse before better.  Removing the virus gives the body the opportunity to heal.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #550 on: November 02, 2015, 05:10:08 pm »
Beto,
I feel like I'm kicking butt! Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #551 on: November 02, 2015, 05:15:39 pm »
Marianne,
Thanks for re doing that. I actually have it from when you posted it earlier a month ago 8) don't worry, you were pretty ill then my love. I have copied this and given it to everyone who needs it.  My GP scanned it for her files. It's a great one to take to the Doctors because it's in their language.  Love the aPublication it gives explanation and hope that some if these co morbidities may improve! Fingers and ties! Cal :-*
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #552 on: November 02, 2015, 05:17:34 pm »
Bree,
Thanks dearest, I think it's best to hit it the best I can! So 4 months it is! Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #553 on: November 02, 2015, 05:19:08 pm »
Bree,
Thanks dearest, I think it's best to hit it the best I can! So 4 months it is! Cal :)

I would have done 4 months Harvoni if they would have given it to me!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #554 on: November 02, 2015, 05:20:04 pm »
Thanks Kim,
Yes it's best I do it now. If I relapse, I'll know I gave it everything. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #555 on: November 02, 2015, 05:27:20 pm »
Marianne,

Great find...love this study.  Besides having PNF issues in my ankles and feet in recent years...I have had many years of CNF complications, and not just talking brain fog, and cognitive issues.  At one point I went through several tests and MS was not ruled out until the end.  I had a dozen symmetrical "lit areas" on my MRI, the neurologist gave me a funny look when he read the scan.  My own doctor suspected the Hep C, but this guy just told me that there was nothing about C and CNS problems in this giant book he held up.  I had a hell of a time...of course ammonia is an issue with liver disease and causes hepatic encephalopathy.  Saw many neurologists.  Thanks..
Hi Beto,
 Your experience sounds similar to mine. I have a lot of co morbidities, that I had to convince some professors was HCV related. In the end they believed me and said come back after tx and SVR. I must SVR, please please! I was tested for MS as well. The virus has impinged on every area of our lives without us knowing it. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #556 on: November 02, 2015, 07:16:37 pm »
Cal...

you will you will you will  SVR and though you are   :'( now, soon you will be  ;D
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Else

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  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #557 on: November 02, 2015, 07:49:35 pm »
You go, Cal.  Plenty of Viekirians who did 24 weeks. 

In for a penny, in for a pound. 
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #558 on: November 02, 2015, 08:29:09 pm »
Beto,
Thanks for the encouragement. I do get worried at times. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #559 on: November 02, 2015, 08:29:56 pm »
Hi Else,
Yep while I'm at it! Cal 8)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Else

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  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #560 on: November 02, 2015, 08:43:28 pm »
And before you can say 'Bob's yer uncle' you'll be done.

(I'm an Aussie wannabee.  Must have been that 14 years I spent with my blue heeler Jack.  Sure do miss that dog.  It's been 6 1/2 years since he passed.  One of those once-in-a-lifetime companions.  Guess that makes me lucky.)
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #561 on: November 02, 2015, 09:00:49 pm »
Else,
You must come visit. It' a beautiful country. With you're fluency Australian you'd fit right in! Cal 8)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #562 on: November 03, 2015, 04:19:57 pm »
Day 76. Tomorrow 11 weeks. I see GP today, so I may get some blood results early. If nit Gastro tomorrow. Cal  :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline abacomike

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  • Posts: 25
Re: Cal on Vierkira Pak & Ribas
« Reply #563 on: November 04, 2015, 07:24:52 pm »
Hi, Cal.  Just finished taking my 5th full daily dose of Viekira Pak and Ribavirin.  Same old side effects but they have not been significant enough to worry about.  I'm affected more with insomnia, even with the Tamazspan the doctor gave me.  Still doing my daily 1-1/2 mile walks but usually need to nap a bit in the afternoons.  Over the last few months when I was on Harvoni (which failed to clear the virus at week 14 (4 weeks after the 12 week regimen) I was only affected by headaches occasionally and the insomnia.

I'll keep plugging away - 24 weeks is a long treatment.  Hope you are doing well!
Contracted 1980 after blood transfusion
Diagnosed 1996
Ribavirin + Pegasis interferon failed 2006
Harvoni 12 week regimen - recurred week 16
Started Veikira Pak + Ribavirin 10/31/2015 for 24 weeks
Failed Harvoni and Veikira Pak - then had heart attack
Liver Cancer 4/12/2016; Liver resecton 9/22/2016
Started Epclusa 4/16/2017; Epclusa extended for 12 more weeks.  Viral undetected while on Epclusa
Viral Load 354,000 6/1/2015
Viral load 150,000 10/18/2015
Viral Load 550,000 4/16/2017
Genotype 1a

Offline Michael0543

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  • Posts: 5
Re: Cal on Vierkira Pak & Ribas
« Reply #564 on: November 04, 2015, 08:26:30 pm »
I wish you the best with the new drug therapy. I will finish up 12 weeks of Harvoni on Nov 16. What genotype do you have? I didn't see it anywhere in your posts. I may have missed it though.
Contracted Dec 2014
Diagnosed June 2015
VL 650,000. GT 1a
Treatment naive
Started Harvoni 8/25/15 for 12 weeks
9/22/15 HCV Not Detected; ALT 13; AST 24
11/16/15 Finished Harvoni
2/10/16 HCV Not Detected: ALT 13; AST 25

Offline Scoutdoy

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  • Posts: 452
Re: Cal on Vierkira Pak & Ribas
« Reply #565 on: November 04, 2015, 09:22:10 pm »
You are almost there Cal....my Kansas City Royals won the World Series and this city has not slept since.....I went to the parade yesterday along with 800,000 other people. It was very exciting! I think I read that you are doing 4 more weeks right? So will you actually be finished in December? I can tell you that since my treatment stopped ...the insomnia I experienced the last few weeks went away and my appetite came back...boy did it! If it doesn't move while in front of me...I ate it...lol

World Series champions Royals
Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline slats1056

  • Member
  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #566 on: November 04, 2015, 10:05:40 pm »
 Hey Scout, Looks like You & Your Royals both won the World Series :). Glad Your are feeling better!
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline abacomike

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  • Posts: 25
Re: Cal on Vierkira Pak & Ribas
« Reply #567 on: November 04, 2015, 11:41:17 pm »
Michael, my genotype is 1a.  This is my 3rd regimen of hep C antiviral mess.  Two previous tries failed including Harvoni for 12 weeks.  Virus re-emerged 4 weeks after last dose of Harvoni.

My viral loads are quite low compared to most - I think my immune system has tried fighting this for many years.
Contracted 1980 after blood transfusion
Diagnosed 1996
Ribavirin + Pegasis interferon failed 2006
Harvoni 12 week regimen - recurred week 16
Started Veikira Pak + Ribavirin 10/31/2015 for 24 weeks
Failed Harvoni and Veikira Pak - then had heart attack
Liver Cancer 4/12/2016; Liver resecton 9/22/2016
Started Epclusa 4/16/2017; Epclusa extended for 12 more weeks.  Viral undetected while on Epclusa
Viral Load 354,000 6/1/2015
Viral load 150,000 10/18/2015
Viral Load 550,000 4/16/2017
Genotype 1a

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #568 on: November 05, 2015, 12:05:31 am »
Hi Scout,
They won! Wahoo! I'm so glad for you. I can just see you at the parade! Yeah week 11 today and one more week and I'm off the ribas! Hooray. Then a month of Viekira. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #569 on: November 05, 2015, 12:08:19 am »
Hi Mike,
Yeas 24 weeks is a long time but you can do it. Yes you'll recognise some of the old sxs coming through. That insomnia is a treat isn't it. I have temaz too but it doesn't always work. :(

Keep up  the walking it will help in post tx. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Cal on Vierkira Pak & Ribas
« Reply #570 on: November 05, 2015, 06:27:13 am »
Hi Mike, 24 weeks seems long but you get into the groove and it's finished before you know it. Look at it as the gold standard of treatment. If Anything's going to kill the little buggers it will be a 24 week DAA treatment.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Cal on Vierkira Pak & Ribas
« Reply #571 on: November 05, 2015, 06:28:11 am »
Cal, you are nearly done!
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Else

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  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #572 on: November 05, 2015, 10:10:00 am »
Scout!  I saw some pics and that was some parade.  Wow!!!

Hi Mike - 24 weeks of DAA is pulling out the big guns.  I'm sure this will turn the tide for you.

Cal it looks like you've got two finish lines coming up.  Yay to both!!!
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #573 on: November 05, 2015, 05:06:26 pm »
Hi Phily,
Nit quite finished. One more week and finish RIBA s, which seems like finishing in itself! But have another extra month of Viekira to go. Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #574 on: November 05, 2015, 05:08:56 pm »
Else,
I never know, is that you in the pic or some gorgeous Hollywood starlet? Considering that I thought your last Avatar was you.........Eminem!

So no not quite finished but close. Unless you count 12 weeks of ribas and finishing the,! Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Else

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  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #575 on: November 05, 2015, 05:39:57 pm »
LOL.  No, not me.  "Carol" from The Walking Dead tv show.  Everybody's favorite, loyal, cookie-baking mom.  She's just, ummm, practical.  Yeah, that's the word.  She's not mean-spirited but she does get things done that need to be done.  And she's not terribly sentimental.  Actually, I'm a lot like that.

I've picked avatars for fun that suited my mood at the time.  I was Eminem-angry for quite a while.  Now I'm much more composed - in a "Carol" kind of way. Cookies, anyone?  :)
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #576 on: November 05, 2015, 05:48:55 pm »
Aha,
 :-[ :-[ :-[ :-[
I'm sure your even prettier. The Waking Dead. I've heard of it. Is that the Zombie one? Worth watching? I am still watching Orange is the new Black. Also my fave show is Outlander, but were in drought lander at the moment waiting for the nxt series, don't you hate that? TV has been my constant companion as I've been unable to read or do anything that requires a clear head. Hopefully no ribas will cure that. Though my brain fog was very bad before I started tx.

Cal ::)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Else

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  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #577 on: November 05, 2015, 06:00:26 pm »
It's the Zombie one and YES, it's worth watching.  The zombie's quickly turn into background noise.  It's really a post-apocalypse soap opera.  I didn't tune in until the 5th season but was quickly hooked and binge-watched the whole series on Netflix until I caught up. 

Carol's character development has been a sight to see.  At first she was my least favorite character.  A helpless, downtrodden mouse.  Now?  Not so much.  ;)  Arguably the series's strongest member. 

If you watch the pilot episode on Season 1 you won't regret it.  It good enough to be a stand-alone movie.  But, of course, you want to find out what happens next...

I've heard of Outlander - and saw it for sale at Target.  I know Marianne has mentioned it.  But it's not on Netflix and we have no premium channels.  I love period pieces, tho.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #578 on: November 05, 2015, 06:48:12 pm »
Else,

Love the choice of avatar.  Maybe we all should chose a walking dead character.  Or game of thrones is pretty rich in strong and complex characters.  Cal...whats up with the TV thing.  me too...I used to never watch TV.  Now I've learned about the concept of binge watching.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Cal on Vierkira Pak & Ribas
« Reply #579 on: November 05, 2015, 07:09:39 pm »
Else, Outlander is based on Diana Gabaldons well-crafted bodice rippers set more or less in 18th c Scotland and colonial America. You've no doubt seen then if not read them.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: Cal on Vierkira Pak & Ribas
« Reply #580 on: November 05, 2015, 07:12:45 pm »
Speaking of bingeing I'm always looking for suggestions and have been meaning to follow up Walking Dead - now I shall. If you are looking for a gorgeous quirky Brit comedy look at Scrotal Recall. So very much better than the name suggests.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Cal

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  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #581 on: November 05, 2015, 10:07:53 pm »
Else,
Don't worry the zombie thing doesn't phase me. Also love a good character driven story. Outlander is almost sci fi in parts but as you say that fades into the background to the story.

Yes Phily the books are great, I have the series here to read, but my brain won't let me, even a good bodice ripper! Hopefully I shall be ok after the Ribas. I have another month of Viekira after this week so am always looking for good suggestions for series. I look into Scrotal Recall and Walking Dead. Hope I get my brain back soon. I miss it.  :'(

Yes Bill, I Binge watch as well, I lay with my ipad on my chest watching basically anything. I think in some of us, it takes that concentration away. Drats! :-\Cal
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline slats1056

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  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #582 on: November 05, 2015, 10:24:47 pm »
 I told You guys this place was being taken over by Zombies >:( , Now there is proof! Just look at Else, She used to be a normal disenfranchised angry young rapper! Now look at Her :o ::) DVR is the bane to My existence. I've become a procrastinator like My wife & son---- Why do today what You can put off until tomorrow?
 Don't know about Game of Thrones either. The Throne part puts Me off here lately  :-[. I like eating as much as the next guy, BUT-------???? ???
  Speaking of Marianne, anybody heard a peep out of our Little Alaskan Bluebird :-\ :-\ :-\?
  Else, Semisweet and white chocolate chip with Macadamia nuts & Pecans about the size of a softball, with a big ole' glass of fresh ice cold Milk or a hot cup of strong coffee! So much butter You don't need to grease the cookie sheet Y'all. Strictly dietary and health conscious of course. No wait----that's a contradiction!!!! But then again so is pea-can pie 8) 8) 8) 8) 8)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Else

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  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #583 on: November 05, 2015, 10:25:35 pm »
Warning for Philly!!!  Re: Walking Dead.  There's a brief scene at the end of the very first episode that might really bother you.  This isn't exactly a spoiler, but it needs to be said.  Gratuitous horse violence.  I mean it makes sense in the storyline but it would bother any horse person.  :(

I am fond of horses but I'm a dog person.  If a movie contains gratuitous dog violence (which pretty much means any) it ruins the movie for me.  Any decent plot - scary or not - can easily make do without it.  It's a cheap shot to the emotions and it works so I don't like it.

Sorry to be a buzzkill but I just couldn't not mention it.  Hmmm.  The series is, of course, endless carnage for humans too.  Not sure why that doesn't offend the sensibilities in the same way.  I guess I expect in-your-face gore of any zombie flic.  Goes with the genre. 

F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Scoutdoy

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  • Posts: 452
Re: Cal on Vierkira Pak & Ribas
« Reply #584 on: November 05, 2015, 11:00:08 pm »
Tommy, here is an interesting little tidbit...during the KC Royals parade there were confirmed 800,000 people in a 2.5 million area. There were only 3 arrests during the entire day in that area. I find that to be dam worthy of a congratulations not only for winning the World Series but to the people here in the Kansas City Metropolitan area for controlling themselves and showing the country that hundreds of thousands of people actually CAN celebrate and not make assholes of themselves or embarrass their city in National limelight. It was an incredible day, and one that I, along with my children will never forget

Home of World Series Champs...KC Royals
Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline slats1056

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  • Posts: 765
  • SVR to all and to all a good life!
Re: Cal on Vierkira Pak & Ribas
« Reply #585 on: November 05, 2015, 11:22:28 pm »
 Scout, HERE HERE, Too many assholes out there. The Media always plays to there actions, never to the well mannered having a good time with out promoting violence. They always seem to find the blithering drunks or miscreants out to spoil it for everyone. Seems to be politically incorrect to make them responsible for their actions. Just spin it for higher ratings, so sad. :( :( :( Looks like a trifecta for You to celebrate 8) 8) 8)
73 non ab 98 hep c refused pegint/riba
6-15 Gen.1b 1/2 MIL ALT72 AST37 No cirrhosis
7-15  Harvoni 12 weeks
10-14-15 EOT VIRAL LOAD NON-DET  
12-30-15 EOT+12 VIRAL LOAD NON DET  SVR12            8-9-18 HCV LOAD 1.02IU/ml AST22  ALT30 RELAPSE?
9-18-18 confirmed gt 1b relapse
10-16-18 approved 16 weeks Mavyret

Offline Bree

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  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #586 on: November 05, 2015, 11:57:45 pm »
Hi Everybody... got to chime on Walking Dead.  I'm a fan.  Carol is just plain cool. 
Quiet, steely and sly determination. My son turned me onto it (he also turned me on to the former series Breaking Bad).  And, now the prequel, Fear of the Walking Dead.  I'm embarrassed to say how much t.v. I watch.  It's my entertainment when I'm at home (sad, I know;) 

And, Million Dollar Listing N.Y. and L.A.  And Botched (plastic therapy run amuck and corrected by these two amazing doctors in Hollywood).  And, The Voice.  The Good Wife.  And, Tiny House Nation.  And Property Brothers. See what I mean.  I'm hooked.   
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: Cal on Vierkira Pak & Ribas
« Reply #587 on: November 06, 2015, 01:04:53 am »
Bree,
In your and therefore my defence, there's some really good television being made these days! Cal :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #588 on: November 06, 2015, 01:09:36 am »
Bree,
In your and therefore my defence, there's some really good television being made these days! Cal :)

Yep, agreed!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline Else

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  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #589 on: November 06, 2015, 03:08:50 am »
But then again so is pea-can pie 8) 8) 8) 8) 8)

That's pea-con pie, ya Texas waddy!  ;)  And I'll be telling my BIL about those macadamians!!! That would make those cookies about perfect.

I like what I learn here.  Got to learn what a bodice ripper novel was.  So Fabian was the king of the bodice ripper covers, yes?

Scrotal Recall?  **snicker**  That's my kind of a bad pun.

Beto - it was a tough call between Daryl and Carol.  Who would you be?

Bree, I'm getting a kind of "Maggie" vibe from you.  Not quite sure.  Ya think?

And Tommy???  Abraham without the carrot top, maybe?  Hard to say, hard to say.  Maybe your character hasn't shown up yet.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline BillT

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  • Posts: 573
Re: Cal on Vierkira Pak & Ribas
« Reply #590 on: November 06, 2015, 05:11:59 am »
This looks like a great place to set up my bon-bon stand. ::)
« Last Edit: November 06, 2015, 05:18:16 am by BillT »
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline beto

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  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #591 on: November 06, 2015, 11:09:07 am »
Well Else, Glenn is dead so not too many positive male characters left to chose from...every dude wants to be Daryl.  Rick has become way to unlikable, also a bad actor.  Hmmm...maybe the Akito dude, but he is pretty mental (not that I'm not...but I will blame my sitch on brain fog).

THIS JUST IN: ACCORDING TO A FIBROSCAN I HAD YESTERDAY, AND IF THERE ARE NO MECHANICAL OR, SOFTWARE GLITCHES, MY SCORE WENT FROM F4, 14.5 TO A F0-1,  6.5...IN ONLY 4 MONTHS.  MIRACLE?

I had a story for it but my computer rebooted overnight and I did not save.  I think it is better to "wait and see".  I still have no EOT results and have to retake bloodwork.  We all know to be cautious with these tests.  But seriously, if this holds and the scans were both true...that would qualify as a cirrhosis reversal, just sayin'   
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline abacomike

  • Member
  • Posts: 25
Re: Cal on Vierkira Pak & Ribas
« Reply #592 on: November 06, 2015, 11:20:55 am »
Cal, that would be great!  Reversing cirosis is very difficult - but the liver is one of the few organs in the body that has regenerative potential.

Just finishing up my first full week on Viekira Pak and Ribavirin.  You were correct, as always, that the insomnia is the tougest side effect.  I have been very weak and tired these past couple of days.  I take my first blood test a week from Monday - hope I not suffering from anemia.

To be quite honest, I am somewhat pessimistic that this 24 week regimen will rid my body of the Hep C.  After 12 weeks of 0 viral load while on Harvoni and 4 weeks later a jump to 150,000+ viral count, I sure was a little depressed.  But, that depression has been replaced with pessimism.

Good luck on the test results!  :)
Contracted 1980 after blood transfusion
Diagnosed 1996
Ribavirin + Pegasis interferon failed 2006
Harvoni 12 week regimen - recurred week 16
Started Veikira Pak + Ribavirin 10/31/2015 for 24 weeks
Failed Harvoni and Veikira Pak - then had heart attack
Liver Cancer 4/12/2016; Liver resecton 9/22/2016
Started Epclusa 4/16/2017; Epclusa extended for 12 more weeks.  Viral undetected while on Epclusa
Viral Load 354,000 6/1/2015
Viral load 150,000 10/18/2015
Viral Load 550,000 4/16/2017
Genotype 1a

Offline Scoutdoy

  • Member
  • Posts: 452
Re: Cal on Vierkira Pak & Ribas
« Reply #593 on: November 06, 2015, 12:04:41 pm »
Beto,,,are you serious? Is that true? Maybe you weren't really an f4!!!! Who cares,,,,that's awesome,,,,wow!



Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: Cal on Vierkira Pak & Ribas
« Reply #594 on: November 06, 2015, 12:25:07 pm »
OMG Beto!!!!!  That is fantastic.  How soon do you get your new blood work back?
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: Cal on Vierkira Pak & Ribas
« Reply #595 on: November 06, 2015, 12:30:27 pm »
THIS JUST IN: ACCORDING TO A FIBROSCAN I HAD YESTERDAY, AND IF THERE ARE NO MECHANICAL OR, SOFTWARE GLITCHES, MY SCORE WENT FROM F4, 14.5 TO A F0-1,  6.5...IN ONLY 4 MONTHS.  MIRACLE?

Wow, Beto!! That is fantastic!! Can give hope to all.

kim
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #596 on: November 06, 2015, 12:33:48 pm »
Let's put it this way scout.  I had a biopsy 17 years ago and was an f-2.  This scan puts me lower that I was 17 years ago...again if no software or other issues.  The scanner they use is one of 2 in our city.  Gilead sends folk there for scans.  It is one of the better machines.  I did not question it when I got the horrible "cirrhosis" news back in June...but, am cautious for this one.  It was done on the same machine.  There is no way I can go back to June for a biopsy to see if the 1st was correct.  I am not alone by the way.  Let's hope it is real.  Pinch me?
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #597 on: November 06, 2015, 12:35:12 pm »
re-doing blood monday else
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

Offline Bree

  • Member
  • Posts: 576
  • "Today is a good day for a great day!"
Re: Cal on Vierkira Pak & Ribas
« Reply #598 on: November 06, 2015, 01:25:12 pm »
Beto, that's so cool... you have been studying and writing about possible liver damage reversals and wa la!!!

I wish I had a fibroscan as a baseline.  My doc didn't bother.  Just ultrasound and fibrosure as fibroscan machine on different island. 

Anyway, I'm feeling like it's a really positive sign for you!
Dx 1997 Geno 1a
2002-2003 PEG Intron/riba (48 wks) respond/relapsed
Pre-Harvoni - Viral Load: 13.5 M - Log 7.1
Fibrosure Score F1-2  Pre-Treatment:  AST 73 / ALT 88

7/6/15 Started Harvoni (12 weeks)
10/5/15 HCV NOT DETECTED (One week post EOT)
11/9/15 NOT DETECTED!!! (6 wk post)
12/21/15 NOT DETECTED (12 wk post) 
3/14/16  NOT DETECTED (24 week post)AST 26 ALT 18
SVR ACHIEVED!!! 
CURED YES!!!

Offline beto

  • Member
  • Posts: 548
  • "no risk it, no biscuit"
Re: Cal on Vierkira Pak & Ribas
« Reply #599 on: November 06, 2015, 02:07:44 pm »
thanks Bree and all,

Funny on an ethereal note, yes I have been on that bandwagon and who knows "law of attraction?"  nice to think so.  I have had discussions about this with some smart people and as we have been discovering here on HepForum, remove the burden and then let the body to it's thing.  These meds lift a big burden, and muy rapido  Still...I will keep a low key...and be happier yet when I see even more reports like this one.  I don't want to jinx it  :)
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
12EOT-UD-ast/alt19/21
25wk-SVR! 19/18

 


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