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Author Topic: I think I took two doses 6 hours apart  (Read 11266 times)

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Offline Sheltonmj

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  • Posts: 36
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I think I took two doses 6 hours apart
« on: September 18, 2015, 09:07:45 pm »
I have this feeling like I took two dose today.
 It was my worst day yet is one reason.
 Another is I have been carefull to get up at 130 am and take my mess then tell Siri to make a note I took my pill.
 I got up at 8.
 I am very foggy. I have to make notes and set reinders and alarms daily to compensate. I am physically isolated from people and have to cope by myself.
 I depend on Siri exstencibly.
 So when I woke up no note. I counted pills and calendar for reference points and I came up 1 pill short.
  So now I have a new rule. Siri must be plugged in and alarm set.
But what about my mistake I made. It's too late. Will it hurt my cure?
Been infected since early 80s
60
W male
Genotype 1a
 F4 cirosis
 Vl 4,000,000

Offline lporterrn

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  • LucindaPorterRN
    • LucindaPorterRN
Re: I think I took two doses 6 hours apart
« Reply #1 on: September 18, 2015, 09:54:58 pm »
No - it won't affect it. It happens a lot.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Sheltonmj

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Re: I think I took two doses 6 hours apart
« Reply #2 on: September 18, 2015, 10:16:33 pm »
Thanks Lucinda.
I am taking my next dose at 130am.
 
Been infected since early 80s
60
W male
Genotype 1a
 F4 cirosis
 Vl 4,000,000

Offline Philadelphia

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  • It only looks like I know what I'm doing
Re: I think I took two doses 6 hours apart
« Reply #3 on: September 18, 2015, 10:31:42 pm »
Hi Shelton, I needed to get myself a pill box so I could have a visual reminder of whether or not I'd taken my pills. I could see at a glance if I'd mucked it up. I also have a med reminder app on my phone that I have to switch off when I take my meds or it beeps annoyingly at me for hours
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Sheltonmj

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Re: I think I took two doses 6 hours apart
« Reply #4 on: September 18, 2015, 10:50:34 pm »
Thanks. I am getting a box and app.
Been infected since early 80s
60
W male
Genotype 1a
 F4 cirosis
 Vl 4,000,000

Offline Rosie13

  • Member
  • Posts: 297
Re: I think I took two doses 6 hours apart
« Reply #5 on: September 18, 2015, 11:30:34 pm »
Hi sheltonmj,I'm feeling for you...my big fear is screwing up my days & pills.One thing I did after alot of reading on this forum was noticing all the different times people chose to take their meds.Some early risers take right when the get up but I have alot of pets so I chose noon because I want to work in the morning & sit down @ noon for an hour after taking Harvoni.waking up at 1:30 would be hard for me to handle ...most of us have brain fog so I wonder if adjusting your time would help.How are you feeling? You must have cleared alot of virus today yeah!
Labs August 15,2015
Genotype 1b
AST 112 U/L
ALT 181 U/L
HCV 192,000 IU/mL
Fibroscan F2-3
Started Harvoni Sept. 5, 2015
4wk. labs Oct. 2,2015
AST 21 U/L
ALT 27 U/L
HCV UNDETECTED!!
8wk. labs Nov.5,2015
AST 16 U/L
ALT 19 U/L
HCV UNDETECTED!!
12 wks.post tx.feb.11,2016
UNDETECTED!!!
24 wks. post tx. may 16,2016
UNDETECTED Fibroscan  F-0!!!!!

Offline Mugwump

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  • My number of posts means nothing, piscor ergo sum!
Re: I think I took two doses 6 hours apart
« Reply #6 on: September 19, 2015, 01:04:54 am »
Thanks. I am getting a box and app.
I have been on thyroid med for over 25 years and a cheap plastic daily pill box has saved my a#$ more than once over the years! Just remember that the Harvoni must be kept dry and stable, so as discussed on another thread the worst place to keep the pills is in near a sink in a bathroom.

As far as an app on cell phone goes. I just went old school and used a calendar sheet that I just put a check mark on for each day and the time if I screwed up and took the pill late. I only messed up once in the 24 weeks and that was because I was in a hurry to get my gear together to go steelhead fishing that day and my mind was not on my treatment LOL,

All I did was switch to taking the pill in the afternoon/evening for the remainder of the treatment. So I did not double up on the dose which is not good because it essentially wastes the drug. How toxic is an overdose of Harvoni? Is a question far better answered by Gilead support and your Doctor.

Take care and slay the dragon!
Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Scoutdoy

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  • Posts: 452
Re: I think I took two doses 6 hours apart
« Reply #7 on: September 19, 2015, 01:36:54 am »
I do the same method as Mugwamp. As soon as I swallow a pill I walk over to the calendar and put a check mark on it....I have yet to screw up, which actually stuns me...I am kind of a space cadet...LOL


Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline davidsconfused

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  • Posts: 53
Re: I think I took two doses 6 hours apart
« Reply #8 on: September 19, 2015, 03:25:42 am »
I do the same method as Mugwamp. As soon as I swallow a pill I walk over to the calendar and put a check mark on it....I have yet to screw up, which actually stuns me...I am kind of a space cadet...LOL


Scout

That's what I did.  I took the pill and turned around and marked the calendar.

Offline Sheltonmj

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  • Posts: 36
  • New at this
Re: I think I took two doses 6 hours apart
« Reply #9 on: September 19, 2015, 06:57:53 am »
Hey Thanks Y'all
 For the ideas and support.  It was a terrible day yesterday but this morning I feel pretty good. 
 It was like the side effect doubled yesterday.
 But I am feeling really good today.
 So I got an app for meds.
 I am making a calendar with references as to how many pills I have.
 Buying a pill calendar type pill box today.
 And doing the gym 2 times for punishment. !!!

 You guys are GREAT.
Been infected since early 80s
60
W male
Genotype 1a
 F4 cirosis
 Vl 4,000,000

Offline lporterrn

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  • LucindaPorterRN
    • LucindaPorterRN
Re: I think I took two doses 6 hours apart
« Reply #10 on: September 19, 2015, 05:21:05 pm »
Shelton - is there a reason why you are taking your pill at 1:30 AM?
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Scoutdoy

  • Member
  • Posts: 452
Re: I think I took two doses 6 hours apart
« Reply #11 on: September 19, 2015, 05:49:42 pm »
Lucinda, I just read that if you are on HCV treatment that you should not take melatonin. I know there are thousands of herbs and sleep aids out there but have you ever received any info on this?

Scout
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline Scoutdoy

  • Member
  • Posts: 452
Re: I think I took two doses 6 hours apart
« Reply #12 on: September 19, 2015, 05:51:24 pm »
Oh, I read it on the herbal dietary supplements glossary
F/49yrs
Genotype 1a
infected 1987-tatoo/military?
Diagnosed 2007
Biopsy F-0
vl 13,900,000
AST 23
ALT 19
Harvoni Treatment 7/27/2015
4 week lab --<12 negative...AST 23 ALT 15
6 week lab -- Undetected.....AST 17 ALT 10
8 week lab---undetected.......AST15 Alt 10
12 week lab---UNDETECTED....AST 15 ALT 9
12 week EOT--1/13/2016----UNDETECTED!
24 week EOT ----UNDETECTED  --AST 18 ALT 12
I AM FREE!

Offline lporterrn

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  • Posts: 1,969
  • LucindaPorterRN
    • LucindaPorterRN
Re: I think I took two doses 6 hours apart
« Reply #13 on: September 20, 2015, 12:23:33 pm »
Scoutboy - I don't know which meds you are on, but if you are taking melatonin at night and you are taking Harvoni or sofosbuvir early in the day, there shouldn't be a problem. (ribavirin should be OK) I don't know about Viekira.
Lucinda Porter, RN
1988 Contracted HCV
1997 Interferon nonresponder
2003 PEG + ribavirin responder-relapser
2013 Cured (Harvoni + ribavirin clinical trial)
https://www.hepmag.com/blogger/lucindakporter

Offline Else

  • Member
  • Posts: 523
  • Appeal, appeal, and appeal again!
Re: I think I took two doses 6 hours apart
« Reply #14 on: September 20, 2015, 12:53:40 pm »
Both the pharmacist from the Specialty Pharmacy and the nurse from my doctor's office gave very pointed advise about keeping the Harvoni in its original bottle during treatment.  It seemed a strange detail for two different people to emphasize so I took them at their word.

In hindsight, I think maybe there's a general concern that someone might throw some in a baggie and that into a daypack.  Not stable storage is my point.

But I've totally depended on Sun-Sat plastic pill containers for both vitamin supplements and another pharmaceutical that I've been on for 10+ years.  My days are too similar and my memory too crappy to do something that repetitive without screwing up.

But the pro advice intimidated me into the old-school methods above.  Red pen near office calendar.  Take pill, pen-in-hand, then mark day.  Even with that decision made I had to put a Harvoni in a plastic pill pak yesterday 'cause of an early morning track meet that I was going to be at all day.
F/53 yr
diagnosed 1995
Genotype 1a
ALT: 58 AST: 39 ALK: 105
Viral load 4,201,950 IU/ml
Fibroscan 6.5 (F1-F2) Fibrosure 0.36 (F1-F2)
Treatment-naive
After 3 denials, finally approved!
Harvoni 12 wks - start date 9/15/15
4 wk labs 10/14/15
ALT: 12 AST: 16 ALK: 85
HCV Not Detected!!!
8 wk labs 11/10/15
ALT: 13  AST: 15  ALK: 77
12 wk (EOT!) labs 12/8/15
ALT: 11 AST: 15 ALK: 78
HCV Not Detected!!!
10wk posttx labs 2/11/16
ALT: 22 AST: 17 ALK: 61
HCV Not Detected!! SVR10!!!
SVR10 (99.7% Cured!!!)

Offline Mugwump

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  • My number of posts means nothing, piscor ergo sum!
Re: I think I took two doses 6 hours apart
« Reply #15 on: September 20, 2015, 04:20:30 pm »
Both the pharmacist from the Specialty Pharmacy and the nurse from my doctor's office gave very pointed advise about keeping the Harvoni in its original bottle during treatment.  It seemed a strange detail for two different people to emphasize so I took them at their word.
There is a desiccant in the bottle and that is why they say keep them in the original as well as identification of script should a pill bottle be lost. One of the most common problems with using weekly pill boxes in care homes is that some meds will react when in contact with each other and seniors losing very expensive pills!

That being said the pharmacist is just being overly cautious IMO. Like I said on another thread my nurse actually told me to make sure I did not take the plastic thing inside the pill bottle LOL.

Obviously Harvoni needs to be kept in a dry stable environment so if you use a weekly pill case and refill it every week and keep it away from cold, heat and moisture then it will be the same as keeping it in the original bottle.

I never put more than 7 pills in my daily container and I always kept the rest in the original with the desiccant. Logically they are just trying to stop people from doing things that are completely wrong so their advice errs on the side of caution.

Regards
Eric
Caution shameless self promotion below :-)
https://www.hepmag.com/article/eric-reesor-27742-782589663
DING DONG MY DRAGON (HCV) IS FINALLY DEAD!

Offline Philadelphia

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  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: I think I took two doses 6 hours apart
« Reply #16 on: September 20, 2015, 06:17:25 pm »
Often too it's a matter of finding what works for you. I travelled a lot while on treatment and worked odd hours. I wasn't home to mark off a physical calendar sometimes so that wouldn't have helped me. Also because life can throw unexpected obstacles in your way, I always kept two days worth of meds in my bag. If I had to overnight unexpectedly away from home (it happened) I had my tablets with me.

We know ourselves pretty well, sometimes it's trial and error. For me, the  spares, pill box and app were absolute necessities.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013
https://www.hepmag.com/blogger/grace-campbell

Offline Cal

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  • Posts: 957
  • Cal on Viekira Pak
Re: I think I took two doses 6 hours apart
« Reply #17 on: September 20, 2015, 08:23:52 pm »
As long as the pill box is airtight then it won't harm the content of the pill. My doc ga ve me a dies it box but I keep them in the bottle. In the first 2 weeks of tx I had dreams about missing my dose. You have to  do what works for you. Getting up in the night is inviting sleep ins. Maybe make it more regular times like breakfast and dinner. Good luck. Cal  :)
HCV 30 years. Geno 1A.
Veikira Pak with ribas on Compassionate Access.
Brisbane. Australia. began 21.8.15.
17 weeks.  Previous non responder 2011.
V/L 9 million
2 week V/L 54
12 weeks V/L UND
No 17 week  EOT V/L
EOT Post 4 weeks UND.

 


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