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Author Topic: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?  (Read 6368 times)

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Offline D63

  • Member
  • Posts: 44
  • and, so . . .
TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« on: November 10, 2015, 04:09:53 am »
Hi, I'm new here. I'm a 52 year old male, treatment naive patient. I was diagnosed with HCV in 1990. Biopsy in 2001 confirmed geno 1b, with portal fibrosis, and last labs, done in 2011 showed VL at over 6MIL.
I am doing some research to get more information from the current status of other treatment naive patients whom have had the Olysio & Sovaldi treatments 2 to 3 years ago before considering the tx. Where are you now? Any new or other complications in the last 2 to 3 years after taking this treatment WITHOUT RBV or PEG INF.

I am currently in Los Angeles, and would also like to know if OLY & SOV are available in Barcelona, Spain, and covered under the public health system there.
Logged
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline BillT

  • Member
  • Posts: 573
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #1 on: November 10, 2015, 03:25:28 pm »
Hi D63 and welcome,
                              I know there were some protests in Spain at the beginning of the year to get people treated.I'm not sure what is available there or what stipulations the health system has on how far along in liver damage you need to be to get treatment.I'm sorry I can't tell you more but I haven't seen anything about it recently.GL
Logged
Contracted 1973 Military
Diagnosed 1980
Pegintron treatment 2004 unsucessful
Genotype 1b
FibroScan 10 (F2)
Start Viekira 10.17.2015

AST 40 ALT 69
VL 440k
10.31.2015/Week 2 Labs : AST 14/ALT 17
No VL done
10.14.2015/Week 4 labs : AST 14/ALT 14
VL UNDETECTED!!!
12.11.2015/Week 8 Labs : AST 12/ALT 13
No VL done
01.05.2016/EOT labs : AST 15/ALT 13
VL UNDETECTED!!!

12 WEEK SRV:UN-BLOODY DETECTABLE !!!!!!!!

24 WEEK SVR:UNDETECTABLE!!!! Thank You God.

Fibroscan 6Mo. Post Treatment 7.15.2016-5.3(F1)

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #2 on: November 10, 2015, 07:52:44 pm »
Hey Bill, thanks so much for responding! I had heard about those protests. I have a legal residency there but no one savvy enough to ask some questions for me about what's available. I imagine also, that the criteria for receiving the extra fancy over there, is the same as here in the States. I see that you've had the V PAK. Congratulations about your undetectability. I may ask, as I need to know, about this drug. Right now, I'm focusing on finding people who have had the treatments I mentioned, at least 2 or 3 years ago, to make sure before I have a chance to do the treatment. If it's possible to find such people. I haven't in this forum, hence my reason for posting my message.
Thank you for your welcome and I wish you the infinite best.
Logged
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #3 on: November 11, 2015, 02:41:00 am »
Hi D63
I think anyone who was treated with Solvaldi and olysio that long ago it would have been on a clinical trial as they were only approved in the US in November and December of 2013 respectively.

I treated with Sov/Oly for 12 weeks from March 2014 to June 2014 and when tested 12 week later in Sept 2014 I was found to have relapsed.

I finished tx with Sov/Oly 17 months ago not quite the 2 to 3 years you are looking for but I started treatment only 3 months after the meds were approved after a brief fight with my insurance.

I next treated with Harvoni for 24 weeks also with Ribivirin which was started later so for 15 of those weeks. I am now SVR 24 and cured.

I treated 3 times prior with interferon based treatment for 6 months at a time and was a null responder. I also was diagnosed with cirrhosis Jan 2008.

I am not aware of any post treatment effects from any of my multiple treatments.

So not exactly your criteria. What are you trying to determine with your question?

Best of luck to you,
Lynn
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #4 on: November 11, 2015, 03:22:57 am »
Hi Lynn! Thank you for replying.
I'm sorry to hear about the relapse with SOV/OLY.
Yes, I am aware that this time period I'm asking about may include a time when it was in a clinical trial. Some clinical trials may or may not include other medications that a patient may not be aware of.
The point of asking my question is out of caution. I refuse to take RIB or PEG INF combined with any of the newer drugs for my own personal reasons.
I'd like to stay clear of RIB/INF. So, I have been waiting for these new drugs to come down the pipeline and I'm hoping to gather a consensus about SOV/OLY, before I make a decision. I am married to someone in a foreign country and it would be ideal to fight to get something with the least amount of side effects as possible and shorter tx interval. Having this is a strain enough. I've never been treated but I've held many hands of those who have and I have no desire to go through it myself. I just need information. Even being treated a year ago is sufficient.
Congratulations, Lynn. You have been on a long journey. Best of everything to you!
Logged
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED

Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,544
  • Get tested, get treated, get cured, fight Hep c!
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #5 on: November 11, 2015, 03:27:56 am »
Good luck to you as well just to add I did not have any sides on Sovaldi/ Olysio but I did avoid the sun as recommended for the Olysio
Logged
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

Offline D63

  • Member
  • Posts: 44
  • and, so . . .
Re: TX naive who had Sovaldi & Oly 2-3 years ago. What's up?
« Reply #6 on: November 11, 2015, 03:44:49 am »
Lynn, thank you about the sides. And yep, the sun is a real biggie. Stay out of that sun. I noticed you are or were, as the case is, a geno 1a. I'm a 1b. One of my friends, who was a 1b, went through practically the same spin on the INF mono, INF/RIB and then PEG INF/RBV with null response. She, sooner than later, progressed into cirrhosis and other extra hepatic complications, too numerous to mention. Finally, they gave her the SOV/OLY w/o RIB or INF, and she cleared it. She is undetectable. I don't know what her numbers are at the moment.

But, again, thanks for your friendly reminder about the sun, Lynn.
Logged
Genotype: 1A 
Contracted tattoo
Dx in 1990
Fibroscan: 11/15/2016 
Stage: F-0,  5.4 Kpa
Tx naive
Started Harvoni: 1/30/2017 - 8 weeks Tx

Week 1 Starting VL: 3,044,516
AST: 36
ALT: 63
Cryoglobulinemia: positive 12.00
Week 2:
AST: 15
ALT: 20
Week 4 VL: 0- UD
Cryo: NEGATIVE
AST: 16
ALT: 20
Week 8 EOT VL: 0-UD
AST: 15
ALT: 18
Week 12, after EOT of 8 WK Tx: VL: 0- UD
Six months after EOT: VL: 0- UD
ALT: 13
AST: 12

One year after End Of Treatment: Viral Load: 0- NEGATIVE
ALT: 20
AST: 17

CURED
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