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Author Topic: "My Hep C Genotype Switched?"  (Read 6963 times)

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Offline Hep Editors

  • Member
  • Posts: 784
    • Hep Mag
"My Hep C Genotype Switched?"
« on: October 13, 2015, 11:04:04 am »
From Lucinda Porter's latest Hep Exclusive:

"It may be that you have more than one HCV genotype at the same time. When this occurs, often the genotype test shows whichever genotype which is more predominate, and sometimes it can switch. Having more than one HCV genotype is not rare, with studies placing it in the 5 to 10% range.

There is also something called HCV recombination. In this situation, a person may be co-infected with more than one HCV genotype, and the viruses exchange genetic material."

For more information: http://www.hepmag.com/articles/hepatitis_c_questions_2502_27873.shtml

Offline beto

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  • "no risk it, no biscuit"
Re: "My Hep C Genotype Switched?"
« Reply #1 on: October 13, 2015, 10:22:13 pm »
Thank you Lucinda

Great compilation to Q and A.  One question I do not know if you fully answered or rather, I believe there is an extension question that could be asked that is related.

The question had to do with a concern from a C patient that was detectable post treatment, wondering if cure chances were low in the future.  The answer was a "no" (not) based on the Harvoni and the new viral specific treatments.  Part of what I am wondering is;  what about the folks that cleared during Tx and then were detected EOT and EOT 4 weeks, only the clear again after 12 weeks EOT.  Is there any information from clinical sources on that?  I believe about 3 forum members have reported this phenomenon.
HCV/nonA,nonB acute phase 1975
HCV detected active 1990
HCV persistent chronic diagnosis 1995
1995 liver enzymes mild elevations
1996 Biopsy F2 fibrosis
treatment naive geno 1-A
2000-to early 2015 Viral load 150, 000 to 800, 000
recent liver enzymes before treatment alt/ast 59to209,  Fibroscan F4,cirrhosis
start tx Harvoni 7/11/2015
6.5 week-UD-ast/alt 25/25
9wk-UD-ast18 alt23
10/3/15 completed tx
11/5/15 new fibroscan f0-f1 amazed
6wk EOT UD ast/alt 20/20
25wk-SVR! 19/18


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