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Author Topic: Genetic Variation and Spontaneous Hep C Clearance  (Read 6851 times)

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Offline bp9191

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  • Posts: 5
Genetic Variation and Spontaneous Hep C Clearance
« on: October 14, 2015, 04:32:42 pm »
Hello:
I have posted previously when I tested positive for the anti-Hep C Antibody over a year ago. 2 subsequent PCR tests  6 months apart show no detectable virus. A tainted blood transfusion in the mid 1970's is the suspected mode of my infection 40 years ago. I am negatiive for HIV (and have never used any IV drugs).
I have had my DNA anaylsed ( thru 23andme - 2 years ago) and recently ran the raw data thru the program Promethease.  Then I researched the literature in PubMed for spontaneous Hep C clearance and correlation with genetic mutations (SNPs) on specific chromosomes. I came across this paper "IL28B Genetic Variants and Gender Are Associated With Spontaneous Clearance of Hepatitis C Virus Infection" which can be read at this link: http://www.ncbi.nlm.nih.gov/pubmed/22329371
    I have 3 of the 4 featured SNP rs numbers and genotype for spontaneous clearance ( rs 8099917TT, 8105790TT, 1298075AA). -I also have another SNP from another reference: SNP rs4803223AA.
    SO while I was unlucky to received infected blood - I am extremely lucky I have these mutations.
    This was all uncovered through starting the process of DNA testing for familial Parkinsons since I have 3 people in my immediate family with Parkinsons (although I do not).
   

Offline Lynn K

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  • Get tested, get treated, get cured, fight Hep c!
Re: Genetic Variation and Spontaneous Hep C Clearance
« Reply #1 on: October 14, 2015, 11:42:05 pm »
Thanks for the info and congrats on not having hep c
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!
I AM FREE!

 


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