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Author Topic: 14 Weeks into Harvoni  (Read 9241 times)

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Offline Cherylb01

  • Member
  • Posts: 9
14 Weeks into Harvoni
« on: November 17, 2015, 10:59:53 am »
Hi All:

I am 14 weeks into 24 week Harvoni treatment. My viral load went from 330,000 to 12. I was hoping for undetectable. (I know, I'm ungrateful.)

Are there any other retreats out there who sent so far into treatment with similar results and wound up cured?

I'm looking for some hope..feeling very unsettled!

Offline gnatcatcher

  • Member
  • Posts: 1,372
Re: 14 Weeks into Harvoni
« Reply #1 on: November 17, 2015, 11:15:47 am »
. . . Are there any other retreats out there who sent so far into treatment with similar results and wound up cured?
. . .
Cheryl, yes, there are, although I can't remember their monikers off the top of my head. With the new meds, there are forum members who even were still detected at the end of treatment but who went on to achieve a cure.

One of our moderators, Lucinda Porter, RN, posted a Q&A article that explains this. Here's the relevant excerpt:

Q: I just finished HCV treatment, but my viral load was detectable at week 8 and 12.  Does this mean my chances of being cured are low?
A: No. In the old days, back when treatment was long and used interferon, there were clear milestones that helped us know what our chances were of permanently clearing hepatitis C. Now with new direct-acting antivirals (DAAs), things have changed. Research by the NIH Clinical Center showed that low levels of HCV RNA at the end of treatment are not predictive of treatment response among patients with hepatitis C virus treated with interferon-free regimens. (Clinical Infectious Diseases, March 2, 2015) Harvoni was used in this study, but the trend is likely to apply to all treatments using HCV DAAs.

and here's the link to the entire article: http://www.hepmag.com/articles/hepatitis_c_questions_2502_27873.shtml

-hope this helps you feel settled. I don't think your disappointment makes you ungrateful, just human.

Gnatty
9/29/71 transfusions
HCV genotype 1a
7/09/15-9/30/15 Harvoni

Before treatment:
Viral Load 9,490,582
FibroScan 19.5 kPa [F4]
ALT 262
AST 217
ALP 183

Most recent:
VL still UNDETECTED (SVR 102)
FibroScan 7.6 kPa [F1-2]
ALT 15
AST 20
ALP 85

Offline Cherylb01

  • Member
  • Posts: 9
Re: 14 Weeks into Harvoni
« Reply #2 on: November 17, 2015, 12:08:21 pm »
Thanks Gnatty. I am trying so hard to be optimistic, but as a realist I find that difficult. 10 more treatment weeks to go and then waiting another 12 after EOT to find out if "cured"...just feels like a lifetime!

Offline Madelief

  • Member
  • Posts: 60
  • Together we reach the bright site of te road
Re: 14 Weeks into Harvoni
« Reply #3 on: November 17, 2015, 04:48:57 pm »
Cheryl,
I understand your feelings, it is not ungrateful, we or only human.
Wish you the best to deal with your disappointment.
There is so less rest virus, that will disappear, but takes more time and that is hard at this moment
start Harvoni 11-02-2015 (november)
Bloodtest 11-09-2015 alt 45 (before treatment 145)
8 weeks treatment
F1
Bloodworks 11-23-2015
HCV not detectable!!!
Rest of the numers in a normal range : ))))

Offline dragonslayer

  • Member
  • Posts: 873
Re: 14 Weeks into Harvoni
« Reply #4 on: November 18, 2015, 09:41:28 am »
Hi All:

I am 14 weeks into 24 week Harvoni treatment. My viral load went from 330,000 to 12. I was hoping for undetectable. (I know, I'm ungrateful.)

Are there any other retreats out there who sent so far into treatment with similar results and wound up cured?

I'm looking for some hope..feeling very unsettled!

Hi Cheryl,

This happened to me.  Im not a 'retreat', but I was given 8 wks of Harvoni.  At EOT, I was Detected 29..  Even at 7.5 wks post treatment, I was still detected but heading in the right direction at <LLOQ(12).  Finally, at 11 wks post treatment, I hit UND SVR, as well as at 24 wks post treatment UND SVR.

Its not at all unusual with Harvoni to be low level detected near EOT or even after, and still resolve by the 12 wk post treatment SVR marker.

Best of luck to you!
« Last Edit: November 18, 2015, 09:43:02 am by dragonslayer »
Paul

DX 2008
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result:  Detected 29
7.5 wk post tx: Detected < LLOQ(12)
11 wk post tx: UNDETECTED SVR12
24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22; ALP 73
48 wk post tx: UNDETECTED SVR48; AST 18; ALT 18; ALP 70
GT 1a
vl 2.4mil
2008 bpx: Stage&Grade 0
2013 bpx: Stage&Grade: 0-1
IL28B: TT
likely infected early '70s

Offline Cherylb01

  • Member
  • Posts: 9
Re: 14 Weeks into Harvoni
« Reply #5 on: November 18, 2015, 10:16:12 am »
Thanks for the encouragement Dragonslayer! Just what I needed to hear!

Offline chino1969

  • Member
  • Posts: 117
Re: 14 Weeks into Harvoni
« Reply #6 on: November 30, 2015, 11:15:05 am »
Cheryl, you will be fine.  Have faith & patience.

Offline Cherylb01

  • Member
  • Posts: 9
Re: 14 Weeks into Harvoni
« Reply #7 on: December 02, 2015, 03:23:19 pm »
Thanks Chino. More blood work tomorrow. 16  weeks...

Offline Cherylb01

  • Member
  • Posts: 9
Re: 14 Weeks into Harvoni
« Reply #8 on: December 10, 2015, 03:27:53 pm »
16 Week labs say the following:

"Test Information:
Note: . The quantifiable range of this ass
ay is 12 to 100,000,000 IU/mL for genot
ypes 1-6 and the limit of detection of the
assay is 12 IU/mL.
See Note completed 12/03/2015
Hepatitis C Quantitation
Note: HCV RNA detected
<12 IU/mL completed 12/03/2015
HCV log10
Note: Unable to calculate result since no
n-numeric result obtained for component
test.
TNP
log10_IU/mL
completed 12/03/2015"

Can anyone translate for me? Still detectable but <12? If that is the case, this seems to be as low as I'm gonna get!

Offline KimInTheForest

  • Member
  • Posts: 1,972
  • Believe in yourself
Re: 14 Weeks into Harvoni
« Reply #9 on: December 10, 2015, 03:35:50 pm »
Hi Cheryl. I think you will reach undetectable at some point. Some people take longer than others, but nearly everyone on Harvoni does get to "undetectable" eventually - either during or post-treatment. A result like yours ("HCV RNA detected <12 IU m/L") is standard for all of us at some point during treatment.

kim :)
Kim Goldberg (Nanaimo, BC)
1970s: Contracted HCV (genotype 3a)
2015: Cured with Harvoni + ribavirin (12 weeks)
MY STORY: https://pigsquash.wordpress.com/2016/01/28/undetectable-my-hep-c-story/

Offline Cherylb01

  • Member
  • Posts: 9
Re: 14 Weeks into Harvoni
« Reply #10 on: December 12, 2015, 01:30:17 pm »
Has anyone experienced pain in the region of their liver while on Harvoni? I'm mid way through week 18 &  I feel like I'm severely bruised..very uncomfortable!

Offline jakas

  • Member
  • Posts: 265
Re: 14 Weeks into Harvoni
« Reply #11 on: December 12, 2015, 01:58:35 pm »
yes yes every day before and now on Harvoni. Feels like the area is swollen. Pain spreads to the lower back too. Its a dull pinching pain
M/57 yrs.
Contracted (Unknown) 10-20-30 yrs back ??
Treatment Naive
Geno 1a&1b
VL  17+ million
ALT 200+, AST 170+
Fibroscan F4 ( 26+ kpa ) on 8th Dec. 2105
Started Tx 11th Dec.2015 ( 12 wks. Gilead Harvoni)
7/1/2016 :Viral Load|<25 UND.
23/1/2016: ALT 34 , AST 35, ALP 143
8 week NO labs done
EOT:03.03.2016 ( 84 pills eaten )
ALT 26, ALP 124, BIL .54
V/L <25 UND E.O.T.
4 weeks E.O.T. V/L UND::: SVR 4
SVR 12 and  SVR 24 on 16/8/16
Fibro 24.5kpa 23/05/16
SVR 63 05/17
Fibro 17.03.2020 kpa 6.3

 


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