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Author Topic: post-AbbVie  (Read 7454 times)

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Offline Nobody Special

  • Member
  • Posts: 7
« on: December 07, 2015, 09:13:31 pm »
Did anyone here go thru Abb-Vie treatment?

I enrolled in clinical trial in 2013.
This was my protocol: for 12 weeks.
dose twice a day.  in morning, take all five:
ABT-450/r, a protease inhibitor
        taken with ritonavir;
the NS5A inhibitor ABT-267;
the non-nucleoside polymerase inhibitor ABT-333;
and ribavirin ( as placebo )
in evening, just ritonavir & ribavirin

Immeasurably good news: it was successful, and I hear no one has relapsed.

The reason I ask:

I developed acid reflux during the trial.
At the time, I was prescribed Omeprazole,
(a PPD), which was effective.  A while after the trial,
it was no longer effective.  General Practitioner
prescribed Famatdine, which didn't work.  Prilosec
was effective while I took it, but box says don't take
for four months after.

Actually, I've developed a suite of symptoms which may or may not be related to the acid reflux :

After 8 months, the dizziness and ravenous hunger have subsided; remaining still are constipation, the acid reflux, heartburn, and nausea, to varying degrees. The latter sometimes precludes ability to work until it goes away. I also awaken with stomach pain, usually one or both sides lateral to nave, sometimes under sternum.
Still have (for me) errratic weight swings (6 lbs).

I've seen an endocrinologist, 2 gastroenterologists, my hepatologist, and my GP, and all I've found out ( via a endoscopy ) is that I've developed low-grade esophagitis, and beginning-stage ulcer near duodenum.

As I flail around in the dark, for diagnosing all my symptoms, and treating them, I'm going back to the first symptom -- acid reflux ( GERD ) which manifested during the clinical trial -- and presenting this to the forum in case anyone has had any similar situation.   Thank you.

Breathing in, I heal myself. 
Breathing out, I heal others. 
May all beings be well.


Offline Lynn K

  • Global Moderator
  • Member
  • Posts: 4,545
  • Get tested, get treated, get cured, fight Hep c!
Re: post-AbbVie
« Reply #1 on: December 08, 2015, 02:04:17 am »
You can take prilosec for longer per doctors orders from what I understand that is the OTC instructions. If you have chronic acid reflux/GERD that needs to be addressed by your gastro they are the experts.

I have that issue but for me it is from a hiatial hernia. I used to smoke and had a terrible cough. Sometimes I felt like I was going to cough myself inside out which is where I assume I developed the hiatial hernia.

Personally I think the clinical trial and your acid reflux are unrelated just occurring at the same time. Being ill can cause stress which can lead to stomach issues as well.

I hope they can find you help to feel better soon

Good luck
Genotype 1a
1978 contracted, 1990 Dx
1995 Intron A failed
2001 Interferon Riba null response
2003 Pegintron Riba trial med null response
2008 F4 Cirrhosis Bx
2014 12 week Sov/Oly relapse
10/14 fibroscan 27 PLT 96
2014 24 weeks Harvoni 15 weeks Riba
5/4/15 EOT not detected, ALT 21, AST 20
4 week post not detected, ALT 26, AST 28
12 week post NOT DETECTED (07/27/15)
ALT 29, AST 27 PLT 92
24 week post NOT DETECTED! (10/19/15)
44 weeks (3/11/16)  fibroscan 33, PLT 111, HCV NOT DETECTED!

Offline Philadelphia

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  • Member
  • Posts: 1,157
  • It only looks like I know what I'm doing
Re: post-AbbVie
« Reply #2 on: December 08, 2015, 03:18:02 pm »
I did 24 weeks with ribavirin but didn't have any of those things you mention either before or during treatment. Does your doctor think they might be related to the ulcer?

Sorry, I'm not much use.
CURED SVR24  Class of 2015
Wk 12 post EOT 30.11.15: ALT 14 AST 22 GGT 22 VL UND
Week 19 07.08.15: ALT 17 AST 23 GGT 25
Week 12 18.06.15: ALT 21 AST 23 GGT 28
Week 8 25.05.15: ALT 23 AST 27 GGT 30 VL UND
Week 4 20.04.14: ALT 30 AST 36 VL 40
Treatment start 23.03.15: ALT 137 AST 185 VL 342,600
Cirrhosis Child-Pugh A, Genotype 1a - Viekira Pak + riba 24 weeks
Total failure interferon/ribavirin/boceprovir Mar 2013


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